Prognosis for ovarian cancer

Project description

We will study the effect of hormone-related etiological factors for ovarian cancer on tumour characteristics, and 5 and 10 years recidive-free survival. Study subjects are 917 women with ovarian cancer recruited in an earlier case-control study carried out between 1993-1995 in Sweden.

Our hypotheses are:

• Null parity (Infertility), use of combined hormone contraceptive, use of hormone replacement therapy, high BMI (obesity) and late menopause are associated  with early tumour stage, high tumour differentiation and endometrial epithelial cancer type.
• These hormone-related exposures lead to a better prognosis, longer time recidive or death, and lower number of recidives / deaths within 5 years of diagnosis.
• Tumor stage, grade of differentiation and histological subtype affect the survival of ovarian cancer patients.

Project leader

Professor

Elisabete Weiderpass Vainio

Phone:	+46-(0)8-524 823 65
Organizational unit:	Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail:	Elisabete.Weiderpass.Vainio@ki.se

Partners

Publications

•  Socioeconomic status and epithelial ovarian cancer survival in Sweden.
  Weiderpass E, Oh J, Algeri S, Bellocco R
  Cancer Causes Control 2014 Aug;25(8):1063-73
•  Predictors of ovarian cancer survival: a population-based prospective study in Sweden.
  Yang L, Klint A, Lambe M, Bellocco R, Riman T, Bergfeldt K, et al
  Int. J. Cancer 2008 Aug;123(3):672-9
•  Use of hormone replacement therapy before and after ovarian cancer diagnosis and ovarian cancer survival.
  Mascarenhas C, Lambe M, Bellocco R, Bergfeldt K, Riman T, Persson I, et al
  Int. J. Cancer 2006 Dec;119(12):2907-15
•  Hormone replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women.
  Riman T, Dickman P, Nilsson S, Correia N, Nordlinder H, Magnusson C, et al
  J. Natl. Cancer Inst. 2002 Apr;94(7):497-504
• Risk factors for epithelial borderline ovarian tumors: results of a Swedish case-control study.
  Riman T, Dickman P, Nilsson S, Correia N, Nordlinder H, Magnusson C, et al
  Gynecol. Oncol. 2001 Dec;83(3):575-85
• Rat hepatocytes in primary culture synthesize and secrete cellular fibronectin.
  Odenthal M, Neubauer K, Baralle F, Peters H, Meyer zum Büschenfelde K, Ramadori G
  Exp. Cell Res. 1992 Dec;203(2):289-96

More about this study

More information about this study