Prognosis for ovarian cancer

This project studied the effect of hormone-related etiological factors for ovarian cancer on tumour characteristics, and 5 and 10 years recidive free survival. Study subjects were 917 women with ovarian cancer recruited in an earlier case-control study carried out between 1993-1995 in Sweden.

Project description

Our hypotheses are:

  • Null parity (Infertility), use of combined hormone contraceptive, use of hormone replacement therapy, high BMI (obesity) and late menopause are associated with early tumour stage, high tumour differentiation and endometrial epithelial cancer type.
  • These hormone-related exposures lead to a better prognosis, longer time recidive or death, and lower number of recidives / deaths within 5 years of diagnosis.
  • Tumor stage, grade of differentiation and histological subtype affect the survival of ovarian cancer patients.

Project period: 1993 - Ongoing
Main financing: Karl V Jubilee Foundation, Cancerfonden

Project leader

Partners

Mats Lambe, Professor

Rino Bellocco, Associate professor

Pouran Almstedt, Database manager

Publications

Socioeconomic status and epithelial ovarian cancer survival in Sweden.
Weiderpass E, Oh JK, Algeri S, Bellocco R
Cancer Causes Control 2014 Aug;25(8):1063-73

Predictors of ovarian cancer survival: a population-based prospective study in Sweden.
Yang L, Klint A, Lambe M, Bellocco R, Riman T, Bergfeldt K, et al
Int. J. Cancer 2008 Aug;123(3):672-9

Use of hormone replacement therapy before and after ovarian cancer diagnosis and ovarian cancer survival.
Mascarenhas C, Lambe M, Bellocco R, Bergfeldt K, Riman T, Persson I, et al
Int. J. Cancer 2006 Dec;119(12):2907-15

Hormone replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women.
Riman T, Dickman PW, Nilsson S, Correia N, Nordlinder H, Magnusson CM, et al
J. Natl. Cancer Inst. 2002 Apr;94(7):497-504

Risk factors for epithelial borderline ovarian tumors: results of a Swedish case-control study.
Riman T, Dickman PW, Nilsson S, Correia N, Nordlinder H, Magnusson CM, et al
Gynecol. Oncol. 2001 Dec;83(3):575-85

Rat hepatocytes in primary culture synthesize and secrete cellular fibronectin.
Odenthal M, Neubauer K, Baralle FE, Peters H, Meyer zum Büschenfelde KH, Ramadori G
Exp. Cell Res. 1992 Dec;203(2):289-96

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