Infectious diseases and cancer in Uganda

This project focused on cancer epidemiology in Kampala, Uganda.

Project description

Specific aims:

  • To train 5 persons to become independent cancer researchers: focusing on cancer epidemiology in Kampala, Uganda, This is a very poor country in East Africa, with no trained researchers in the field of cancer.
  • To study the genital HPV infection among female adolescents and young women in Uganda (research Project 1)
  • To study the association between conjunctival cancer and various types of human papilloma virus and HIV infection (Research Project 2).
  • To investigate the association between HIV infection and cervical carcinoma, and to study whether immune-suppression caused by HIV infection affects the spectrum of infections with HPV (Research Project 3).
  • To study the etiology, risk factors, clinical features and prognosis of childhood Non-Hodgkins Lymphomas (NHL) in Uganda (Research Project 4).
  • Early cervical lesions detected by visual inspection: Viral factors, management and follow up (Research Project 5).

Partners

  • Cecily Banura, Makerere University, co-PI of the project on HIV, HPV, and other SDTs in teenagers and young pregnant women.
  • Charles Ateenyi Agaba, Makerere University, co-PI of the project project on HIV, HPV and other risk factors for conjuctival cancer
  • Michael Odida, Makerere University, co-PI of the project on HIV, HPV, Malarian and invasive cervical cancer
  • Jackson Orem, Makerere University, co-PI of the project on pediatric Burkitts Lymphoma
  • Twaha Mutyaba, Makerere University, co-PI of the project on cervical cancer screening
  • Leen Jan van Doorn and Wim Quint, DDL Laboratories, Vooburg, The Netherlands, Responsible for the laboratory analysis of all samples in the collaboration for HPV (genotyping), Clamydia (serology and genotyping), and gonorrhoea (serology).
  • Silvia Franceschi, International Agency for Research on Cancer, Lyon, France, as collaborator in the studies by Cecily Banura and Ateenyi Agaba.
  • Silvia de Sanjose, Barcelona University, collaborator in the studies by Dr. Michael Odida and Jackson Orem.
  • Professor Bo Lambert, Karolinska Institutet, collaborator in all studies above.

Main financing: SIDA/SAREC, International Agency for Research on Cancer

Research group

Sven Sandin, statistician

Pouran Almstedt, database manager

Publications

TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis.
Ateenyi-Agaba C, Dai M, Le Calvez F, Katongole-Mbidde E, Smet A, Tommasino M, et al
Mutagenesis 2004 Sep;19(5):399-401

Papillomavirus infection in the conjunctiva of individuals with and without AIDS: an autopsy series from Uganda.
Ateenyi-Agaba C, Weiderpass E, Tommasino M, Smet A, Arslan A, Dai M, et al
Cancer Lett. 2006 Jul;239(1):98-102

Burkitt's lymphoma in Africa, a review of the epidemiology and etiology.
Orem J, Mbidde EK, Lambert B, de Sanjose S, Weiderpass E
Afr Health Sci 2007 Sep;7(3):166-75

Current investigations and treatment of Burkitt's lymphoma in Africa.
Orem J, Mbidde EK, Weiderpass E
Trop Doct 2008 Jan;38(1):7-11

Infection with human papillomavirus and HIV among young women in Kampala, Uganda.
Banura C, Franceschi S, Doorn LJ, Arslan A, Wabwire-Mangen F, Mbidde EK, et al
J. Infect. Dis. 2008 Feb;197(4):555-62

Detection of cervical human papillomavirus infection in filter paper samples: a comparative study.
Banura C, Franceschi S, van Doorn LJ, Wabwire-Mangen F, Mbidde EK, Weiderpass E
J. Med. Microbiol. 2008 Feb;57(Pt 2):253-5

Human Papillomavirus type distribution in invasive cervical cancer in Uganda.
Odida M, de Sanjosé S, Quint W, Bosch XF, Klaustermeier J, Weiderpass E
BMC Infect. Dis. 2008 Jun;8():85

Prevalence, incidence and clearance of human papillomavirus infection among young primiparous pregnant women in Kampala, Uganda.
Banura C, Franceschi S, van Doorn LJ, Arslan A, Kleter B, Wabwire-Mangen F, et al
Int. J. Cancer 2008 Nov;123(9):2180-7

Clinical characteristics and outcome of children with Burkitt lymphoma in Uganda according to HIV infection.
Orem J, Maganda A, Mbidde EK, Weiderpass E
Pediatr Blood Cancer 2009 Apr;52(4):455-8

Comparison of human papillomavirus detection between freshly frozen tissue and paraffin embedded tissue of invasive cervical cancer.
Odida M, de Sanjose S, Sandin S, Quiros B, Alemany L, Lloveras B, et al
Infect. Agents Cancer 2010 Sep;5():15

HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study.
Odida M, Sandin S, Mirembe F, Kleter B, Quint W, Weiderpass E
Infect. Agents Cancer 2011 Jun;6(1):8

Clinical characteristics, treatment and outcome of childhood Burkitt's lymphoma at the Uganda Cancer Institute.
Orem J, Mulumba Y, Algeri S, Bellocco R, Mangen FW, Mbidde EK, et al
Trans. R. Soc. Trop. Med. Hyg. 2011 Dec;105(12):717-26

Burkitt lymphoma in Uganda, the legacy of Denis Burkitt and an update on the disease status.
Walusansa V, Okuku F, Orem J
Br. J. Haematol. 2012 Mar;156(6):757-60

Thesis in this project:

Other links

More information about the study

Collaboration between KI and Uganda