Theme 1: Inflamm-aging and metabolism
We are interested in understanding the dysregulated immune-metabolic profile in HIV-infected individuals on long-term therapy for clinical intervention so that we can provide a better quality of life.
Although mortality is prevented and/or delayed because of effective combination antiretroviral therapy (cART), people living with HIV (PLHIV) need to take medication life-long. The cART has also shifted the spectrum of morbidity towards non-infectious complications such as cardiovascular and neurocognitive diseases that appear at an earlier age in people living with HIV (PLHIV) than in HIV-uninfected individuals. Inflamm-aging, i.e., human aging characterized by a chronic, low-grade systemic inflammation is a highly significant risk factor for both morbidity and mortality in older adults. During cART, HIV persists in a rare population of long-living, latently infected cells that can contribute to an inflammatory-like state. Our group aims to understand the genetic, cellular, and molecular mechanisms of inflamm-aging in PLHIV on successful long-term treatment. We are applying high-throughput multi-omics technologies (e.g., epigenomics, transcriptomics, proteomics, and metabolomics), along with in vitro and ex vivo experimental methods that help bridge the gap between genotype and phenotype and to understand how it regulates inflamm-aging and age-related diseases in PLHIV. Our studies can, therefore, provide possibilities to therapeutically target the inflamm-aging process through metabolic interference, thus allowing more individualized care.
We have initiated an interdisciplinary study, called AROGYA which means wellbeing in Sanskrit.
The overall aims of the AROGYA project are to use complimentary inter-disciplinary expertise to unravel the physiological and molecular pathways that underline the premature aging of the immune system (immune-aging) and to potentially generate novel therapeutic approaches for age-related diseases with a focus on the people who are living with HIV (PLHIV).
The study is funded by the Swedish Research Council interdisciplinary grant.
To know more - visit: https://arogya.ki.se/.