Research group - Katalin Dobra

We study the differentiation of malignant tumors of the lung and pleura and their molecular signature relating to biological properties such as proliferation and invasion. We identify biomarkers that allow early diagnosis and optimize conditions for individualized treatment.

Research group leader Katalin Dobra

Katalin Dobra

Professor/senior physician
K7 Department of Oncology-Pathology

Group members

Research techniques

  • Cell culture, establishment of primary cells
  • Molecular- and biochemical analyzes
  • Proteomics
  • Lighting and fluorescence microscopy
  • Ex-vivo susceptibility testing of primary tumor cells for cytotoxic substances and drugs

External funding

Research Council, the Swedish Cancer Society, AFA insurance, Heart-Lung Foundation, the Cancer Society in Stockholm, the Swedish Medical Society, Stockholm County Council (Research Fellow), KI Funds, Compass

Teaching assignments

We actively participate in the education of Medical- and Dental Student Programs and the Biomedical Analytical program

Selected publications

Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells.
Javadi J, Heidari-Hamedani G, Schmalzl A, Szatmári T, Metintas M, Aspenström P, Hjerpe A, Dobra K
Cancers (Basel) 2021 Feb;13(4):

Cytoskeletal Organization Correlates to Motility and Invasiveness of Malignant Mesothelioma Cells.
Keller M, Reis K, Hjerpe A, Dobra K, Aspenström P
Cancers (Basel) 2021 Feb;13(4):

Higher concordance of PD-L1 expression between biopsies and effusions in epithelioid than in nonepithelioid pleural mesothelioma.
Mansour MSI, Seidal T, Mager U, Dobra K, Brunnström H, Dejmek A
Cancer Cytopathol 2021 Jan;():

Effusion cytology of malignant mesothelioma enables earlier diagnosis and recognizes patients with better prognosis.
Abd Own S, Höijer J, Hillerdahl G, Dobra K, Hjerpe A
Diagn Cytopathol 2020 Feb;():

Inhibitors of cytoskeletal dynamics in malignant mesothelioma.
Reis K, Arbiser JL, Hjerpe A, Dobra K, Aspenström P
Oncotarget 2020 Dec;11(50):4637-4647

Multiplex Soluble Biomarker Analysis from Pleural Effusion.
Javadi J, Dobra K, Hjerpe A
Biomolecules 2020 07;10(8):

Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells.
Kumar-Singh A, Shrinet J, Parniewska MM, Fuxe J, Dobra K, Hjerpe A
Biomolecules 2020 07;10(7):

Diagnostic performance of a stepwise cytological algorithm for biliary malignancy in primary sclerosing cholangitis.
von Seth E, Ouchterlony H, Dobra K, Hjerpe A, Arnelo U, Haas S, Bergquist A
Liver Int 2019 02;39(2):382-388