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Research group - Agneta Wikman

We study Blood components - In vitro and in vivo functional and release studies. Immunisation during pregnancy - Database studies, clinical prospective studies and experimental studies. Blood transfusions - Database and experimental studies.

Blood transfusions

Evaluation of protocols in massive bleeding.

Epidemiological studies on short term and long term effects of blood transfusion.

Blood components

Platelets: factors involved in the initiation of the storage lesion, effects of preparation and storage
Erythrocytes: effects of preparation and storage

In an EU-sponsored project involving several County Councils of Sweden and several manufacturers of plastics and medical equipment, an attempt will be made to combine new non-PVC blood containers with new storage solutions to create an alternative to the present PVC-DEHP blood bags. Karolinska University Hosptital will be responsible for evaluation and in vitro studies of quality of red cells and platelets in this project.

Immunisation during pregnancy

Erythrocyte immunization: Database studies on neonatal outcome in anti-D and non anti-D immunization. Fetal RHD screening and targeted anti-D prophylaxis- clinical, diagnostic and health economy evaluations.

Platelet immunisation: Clinical and experimental studies on anti-HPA and anti-HLA immunization. Evaluation of clinical protocols.
Development of a prophylactic anti-HPA-1a drug in collaboration in an EU-consortium.

Research group leader Agneta Wikman

Group members

Anette MörtbergAnknuten
Per SandgrenAnknuten
Agneta WikmanAnknuten

Research techniques

  • Database studies
  • Experimental studies (molecular biology methods, flowcytometry, ELISA methods)

External funding

ALF, grants within EU-projects

Teaching assignments

MD program KI, Biomedical Scientists KI

Selected publications

Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry.
Tiller H, Kamphuis M, Flodmark O, Papadogiannakis N, David A, Sainio S, et al
BMJ Open 2013 Mar;3(3):

Consequences of being Rhesus D immunized during pregnancy and how to optimize new prevention strategies.
Tiblad E, Westgren M, Pasupathy D, Karlsson A, Wikman A
Acta Obstet Gynecol Scand 2013 Sep;92(9):1079-85

Effect of plasma-to-RBC ratios in trauma patients: a cohort study with time-dependent data*.
Halmin M, Boström F, Brattström O, Lundahl J, Wikman A, Östlund A, et al
Crit. Care Med. 2013 Aug;41(8):1905-14

Random aggregates in newly produced platelet units are associated with platelet activation and release of the immunomodulatory factors sCD40L and RANTES.
Sandgren P, Meinke S, Eckert E, Douagi I, Wikman A, Höglund P
Transfusion 2014 Mar;54(3):602-12

Noninvasive single-exon fetal RHD determination in a routine screening program in early pregnancy.
Wikman A, Tiblad E, Karlsson A, Olsson M, Westgren M, Reilly M
Obstet Gynecol 2012 Aug;120(2 Pt 1):227-34