Research group - Agneta Wikman
We study Blood components - In vitro and in vivo functional and release studies. Immunisation during pregnancy - Database studies, clinical prospective studies and experimental studies. Blood transfusions - Database and experimental studies.
Evaluation of protocols in massive bleeding.
Epidemiological studies on short term and long term effects of blood transfusion.
Platelets: factors involved in the initiation of the storage lesion, effects of preparation and storage
Erythrocytes: effects of preparation and storage
In an EU-sponsored project involving several County Councils of Sweden and several manufacturers of plastics and medical equipment, an attempt will be made to combine new non-PVC blood containers with new storage solutions to create an alternative to the present PVC-DEHP blood bags. Karolinska University Hosptital will be responsible for evaluation and in vitro studies of quality of red cells and platelets in this project.
Immunisation during pregnancy
Erythrocyte immunization: Database studies on neonatal outcome in anti-D and non anti-D immunization. Fetal RHD screening and targeted anti-D prophylaxis- clinical, diagnostic and health economy evaluations.
Platelet immunisation: Clinical and experimental studies on anti-HPA and anti-HLA immunization. Evaluation of clinical protocols.
Development of a prophylactic anti-HPA-1a drug in collaboration in an EU-consortium.
Research group leader Agneta Wikman
- Database studies
- Experimental studies (molecular biology methods, flowcytometry, ELISA methods)
ALF, grants within EU-projects
MD program KI, Biomedical Scientists KI
Consequences of being Rhesus D immunized during pregnancy and how to optimize new prevention strategies.
Acta Obstet Gynecol Scand 2013 Sep;92(9):1079-85
Effect of plasma-to-RBC ratios in trauma patients: a cohort study with time-dependent data*.
Crit. Care Med. 2013 Aug;41(8):1905-14
Noninvasive single-exon fetal RHD determination in a routine screening program in early pregnancy.
Obstet Gynecol 2012 Aug;120(2 Pt 1):227-34