Skip to main content

Specializing courses

The aim of these courses is to follow up the learning outcomes acknowledged for Function A.

Phenotyping of genetically engineered mice

The course teaches how genetically engineered mice can be phenotyped in a strategic way.

The course aims to teach the basic biology of the laboratory mouse in its context of genetically modified animal models. It will provide an overview of available endpoints, and of the various types of results obtained from different analyses and highlight their complementary value as well as limitations.

The course is on the doctoral level (2.0 ECTS) but open for post docs and researchers. Target audience: any person who is or will be involved with mouse studies.

More information on the course Phenotyping of genetically engineered mice.

Course dates

November 12-21 2019.

Key topics

  • Systematic phenotype analysis
  • Transgenesis methodology and breeding
  • Selection of controls
  • Mouse biology, strain differences and characterization
  • Necropsy techniques, perfusion fixation
  • Post mortem tissue preparation for histology
  • Imaging technique
  • ​Why is the course important for KI's researchers?

Phenotyping is a broad term that encompasses the integrated recording of a set of biological parameters both on clinical and tissue level, to characterize a condition in an organism. Phenotyping is typically useful to characterize genetically engineered organisms. Successful integrated phenotyping of genetically engineered mice helps researchers identify areas of interest associated with genetic condition, adding to our understanding of gene function and regulation.

Admission fee

The course is free of charge for doctoral students registered at Karolinska Institutet.
The course fee for the rest of KI participants is 7 200 SEK (including INDI), and for externals 9 500 SEK (excluding VAT).


The course location is Karolinska Institutet, Campus Solna.

Course leader

Leader for the course is Raoul Kuiper, PhD, DVM Dipl. ECVP Pathology, Karolinska Institutet.

For requests, please contact course director Rafael Frias.


Register for Phenotyping of genetically engineered mice.

Anaesthesia, analgesia & surgery in mice and rats - Paul Flecknell

The main goal of this course is to provide education and training in anaesthesia and analgesia in laboratory mice and rats. The instructor for this course is the internationally recognised expert Paul Flecknell.

Procedures causing pain and discomfort in small rodents must be performed under general anaesthesia. Pain relief must be provided postoperatively and also needs to be provided to prevent pain associated with non-surgical procedures. This course will provide the latest information on laboratory animal anaesthesia and the most recently developed methods of pain assessment and alleviation.

Target audience: education and training in anaesthesia and surgery is required for staff carrying out (Function A) or designing (Function B) major scientific procedures on animals i.e. procedures that require the use of either anaesthesia or surgery. The course is 1,5 credits.

Key topics

  • Anaesthesia and analgesia in rats and mice (lectures)
  • Recognition and evaluation of pain and distress in rats and mice (lectures and video exercise)
  • Intubation, i.v. access (hands-on-practical)
  • How to choose between different anaesthetics (theory and hands-on-practical)
  • How to monitor general anaesthesia (theory and hands-on-practical)

Read more about the course Anaesthesia, analgesia & surgery in mice and rats.

Course dates

December 2-6, 2019.

Admission fee

The course is free for PhD students registered at KI. For all other participants and PhD students from other universities there is an admission fee.

Other participants from KI (post docs, guest researchers etc.): 7 200 SEK (excluding INDI).

External participants: 9 500 SEK (excl. VAT).


The course location is Karolinska Institutet, Campus Solna.


Register here for the course. Please register as soon as possible - the course will be organized if there is at least ten participants.

Priority is given to doctoral students from KI, followed by KI and external participants, in that order.

Course evaluations