Assessment of Lifestyle and Allergic Disease During INfancy (ALADDIN)

The aim of the ALADDIN study is to examine which environmental and lifestyle factors during pregnancy and infancy effect the development of, amongst other things, allergies in children.

The ALADDIN-study started in 2004 and has now included 552 families. The children are followed from pregnancy to ten years of age with physical examinations, extensive laboratory sampling and questionnaire.

Please read more in Swedish.

Group members

Johan Alm, Research Group Leader

Margareta Eriksson, Reg. Nurse

Axel Mie, Assistant professor

Annika Scheynius, Senior professor

Jackie Swartz, MD, PhD

Carina Wallén, Biomedical analyst


Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle. Olin A, Acevedo N, Lakshmikanth T, Chen Y, Johansson C, Alm J, Scheynius A, Brodin P.  Allergy 2022;1583-1595

DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life. Acevedo N, Scala G, Merid Sk, Frumento P, Bruhn S, Andersson A, Ogris C, Bottai M, Pershagen G, Koppelman Gh, Melén E, Sonnhammer E, Alm J, Söderhäll C, Kere J, Greco D, Scheynius A. 
International journal of molecular sciences 2021;22(2):801

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption. Acevedo N, Frumento P, Harb H, Alashkar Alhamwe B, Johansson C, Eick L, Alm J, Renz H, Scheynius A, Potaczek D.
International journal of molecular sciences 2019;20(5):1060

Maternal allergen-specific IgG might protect the child against allergic sensitization.
Lupinek C, Hochwallner H, Johansson C, Mie A, Rigler E, Scheynius A, Alm J, Valenta R.
The Journal of allergy and clinical immunology 2019;144(2):536-548

Vaccination and Allergic Sensitization in Early Childhood - The ALADDIN Birth Cohort.
Swartz J, Aronsson B, Lindblad F, Järnbert-pettersson H, Scheynius A, Pershagen G, Alm J.
EClinicalMedicine 2018;4-5():92-98

Allergy-related disease in relation to early life exposures-the ALADDIN birth cohort.
Marell Hesla H, Stenius F, Järnbert-pettersson H, Alm J.
The Journal of allergy and clinical immunology 2017;139(2):686-688

Anthroposophic lifestyle is associated with a lower incidence of food allergen sensitization in early childhood.
Fagerstedt S, Hesla Hm, Ekhager E, Rosenlund H, Mie A, Benson L, Scheynius A, Alm J.
The Journal of allergy and clinical immunology 2016;137(4):1253-1256.e3

Anthroposophic lifestyle and salivary cortisol are associated with a lower risk of sensitization during childhood.
Swartz J, Lindblad F, Arinell H, Theorell T, Alm J.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2015;26(2):153-60

Differences in exosome populations in human breast milk in relation to allergic sensitization and lifestyle.
Torregrosa Paredes P, Gutzeit C, Johansson S, Admyre C, Stenius F, Alm J, Scheynius A, Gabrielsson S.
Allergy 2014;69(4):463-71

Impact of lifestyle on the gut microbiota of healthy infants and their mothers—the ALADDIN birth cohort.
Hesla Hm, Stenius F, Jäderlund L, Nelson R, Engstrand L, Alm J, Dicksved J.
FEMS microbiology ecology 2014;90(3):791-801

Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood.
Holm T, Rutishauser D, Kai-larsen Y, Lyutvinskiy Y, Stenius F, Zubarev Ra, Agerberth B, Alm J, Scheynius A.
Allergy 2014;69(1):104-12

Lifestyle factors and sensitization in children - the ALADDIN birth cohort.
Stenius F, Swartz J, Lilja G, Borres M, Bottai M, Pershagen G, Scheynius A, Alm J.
ALLERGY 2011;66(10):1330-8

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