Unit of Metals & Health
The aim of our research is to identify toxic effects of metals, and[KB1] further, to understand causal relationships between metal exposure and various diseases, and how susceptibility factors influence these relationships.
Exposure to toxic metals, such as arsenic, cadmium, mercury, and lead, are major threats to public health, globally as well as in Sweden. Exposure often occurs via drinking water and/or food. The unit has for many years been world-leading in research on arsenic and cadmium. Today our research primarily concerns metals with major impact on public health, and for which there still are gaps in knowledge, i.e. for arsenic, cadmium, manganese, lithium, and boron. We also elucidate the importance of essential elements such as iron, zinc, and selenium, as they may interact with toxic metals. A majority of our research is focused on health effects of metal exposure early in life, a particularly sensitive period to toxic insults.
We study mechanisms of metal toxicity, especially oxidative stress, epigenetic and hormone-related changes. Many toxic metals, such as arsenic, cadmium, and lead, cause oxidative stress. Recent research suggests that metals can interfere with epigenetic processes, which may make some metals carcinogenic, although they appear not to be strongly mutagenic. Moreover, epigenetic interference can explain why exposure to metals early in life seem to cause diseases later in life. Several of the metals are endocrine disruptors, particularly cadmium, but the hormone systems affected are still to be identified.
There are large individual differences in susceptibility to metal toxicity and we evaluate sensitivity factors such as gender, nutritional status, and genetics. For example, studies have shown that women generally have higher levels of cadmium in their bodies than men. Genetics seems to play a significant role for metal susceptibility. One of the clearest examples of gene-environment interaction is the gene AS3MT, which we have shown to strongly affect the metabolism and sensitivity to arsenic in the body.
The unit collaborates with many research groups, both in Sweden and elsewhere, e.g., in studies concerning metal exposure around the Mediterranean Sea, in the Seychelles, Bangladesh, and the Andes Mountains. Successful research in this area requires sensitive and specific analysis of specific biomarkers of exposure and early effects. Our exposure measurements are largely based on analyzes by ICP-MS. For speciation of arsenic metabolites, we use HPLC on-line with ICP-MS. The laboratory also has expertise, instruments and methods for analysis of genetic damage, by determination of telomere length, gene expression, and epigenetic changes, including DNA methylation and microRNAs. Further, the laboratory performs genotyping of various types of polymorphisms.
Researchers at the unit participate in health risk assessments, particularly for the EFSA, the Swedish National Food Administration, the Swedish Chemicals Agency, and the American Academy of Sciences. Our research has, for example, been crucial for the risk assessment of arsenic and cadmium performed by EFSA, the American Academy of Sciences, and the US EPA.
- Swedish Research Council
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)
- Swedish Research Council for Health, Working Life and Welfare (FORTE)
- AFA Insurance
- Sida (via Swedish Research Council)
- National Institute of Health, U.S.A.
- Metal exposure early in life and influence on childrens health and development
- Mechanisms of metal toxicity early in life
- The role of nutrition in early life development
- Exposure assessment of water and food pollutants in Sweden
- Genetic and epigenetics of metals
- Exposure to welding particles and effects on the cardiovascular system and the lung
- Chimney sweeping and risk of cancer and cardiovascular disease
The metallomics laboratory performs measurements of toxic and essential trace elements, often within large epidemiological studies (high-throughput). It has been developed and implemented since more than ten years at the unit of Metals and Health, Institute of Environmental Medicine (IMM), KI, and has generated more than 100 original scientific publications. It is primarily a research laboratory, but we may also measure on request, particularly from other research groups, the health sector and Swedish authorities. We aim to develop the laboratory to a core facility at Karolinska Institutet. More information about the metallomics laboratory.