Unit of Integrative Toxicology

Our research ranges from basic, mechanistic research in cell systems, over computer modeling and applied research with human volunteers to practical applications.

The aim is to explore areas central to toxicological risk assessment, with focus on the work environment, indoor air and chemical disasters. One theme is acute effects and toxicokinetics, another concerns the physiological role of the Ah-receptor.

The research areas are:

• Human exposure chamber: toxicokinetics and subtle acute effects
• Toxicity models: PBPK, dermal uptake, population models, dose-response, QSAR
• The physiological role of the Ah receptor: in vitro and clinical studies

Expert Committees

We participate in a number of expert committees that evaluate chemical hazards in the workplace as well as releases during chemical accidents. Evaluations are performed on national and international basis in close collaboration with other Swedish, Nordic, European and American experts.

• The Nordic Expert Group
• Scientific Committee for Occupational Exposure Limits (SCOEL)
• AEGL
• EU-LCI working group
• SBU - Kemisk exponering i arbetsmiljön och hjärt-kärlsjukdom (in Swedish)

Head of Unit

Professor

Lena Palmberg

Telefon:	08-524 822 10
Enhet:	Integrativ toxikologi
E-post:	Lena.Palmberg@ki.se

Research groups

• Lena Palmberg
• Gunnar Johanson
• Anneli Julander
• Joelle Rüegg
• Mattias Öberg

Unit members

	Anna-Karin Alexandrie	Anknuten	anna-karin.alexandrie@ki.se
	Antero Vieira Da Silva	Doktorand	antero.silva@ki.se
	Zahra Dehghani	Anknuten	zahra.dehghani@ki.se
	Michela Di Criscio	Anknuten	michela.di.criscio@ki.se
	Elina Drakvik	Samordnare	elina.drakvik@ki.se
	Elin Engdahl	Postdoc	elin.engdahl@ki.se
	Lena Ernstgård	Forskare	Lena.Ernstgard@ki.se 08-524 822 26
	Koustav Ganguly	Forskare	koustav.ganguly@ki.se
	Gunnar Johanson	Professor, senior	Gunnar.Johanson@ki.se 08-524 877 52
	Anneli Julander	Forskare	anneli.julander@ki.se 08-524 800 52
	Jill Järnberg	Anknuten	jill.jarnberg@ki.se
	Maria Lagrelius	Doktorand	maria.lagrelius@ki.se
	Kjell Larsson	Professor emeritus	Kjell.Larsson@ki.se
	Carola Lidén	Professor emeritus	Carola.Liden@ki.se
	Polina Lizunkova	Anknuten	polina.lizunkova@ki.se
	Johnny Lorentzen	Docent	Johnny.Lorentzen@ki.se
	Klara Midander	Forskarassistent	klara.midander@ki.se
	Peter Moldeus	Professor emeritus	peter.moldeus@ki.se
	Lena Palmberg	Professor	Lena.Palmberg@ki.se 08-524 822 10
	Agneta Rannug	Professor emeritus	Agneta.Rannug@ki.se
	Joelle Rüegg	Forskare	joelle.ruegg@ki.se 08-524 885 18
	Pooria Sabouri	Anknuten	pooria.sabouri@ki.se 073-510 98 76
	Linda Schenk	Forskarassistent	linda.schenk@ki.se
	Bengt Sjögren	Forskare	Bengt.Sjogren@ki.se 08-524 822 29
	Urban Svedberg	Forskare	urban.svedberg@ki.se
	Tania Ahalya Thimraj	Anknuten	tania.thimraj@ki.se
	Swapna Upadhyay	Forskarassistent	swapna.upadhyay@ki.se
	Emma Vincent	Forskare	Emma.Wincent@ki.se
	Carolina Vogs	Postdoc	carolina.vogs@ki.se
	Mattias Öberg	Forskare	Mattias.Oberg@ki.se

Projects

Gunnar Johanson

• Toxicokinetics
• Acute effects
• The Ah-receptor
• Inflammatory markers and coronary heart disease
• Emergency Toxicology
• Mathematical dose-effect analysis
• Toxic gases in ocean freight containers
• Exposure limit setting for the work environment

Anneli Julander

• Cobalt nanoparticles - a risk of uptake and allergy?
• Exposure and skin uptake of cobalt
• Chromium in leather and allergy
• Research Programme Hazardous skin exposure
• Hand eczema and contact allergy in adolescents
• Consumers, cosmetics and skin sensitizers

Lena Palmberg

• Inflammatory mechanisms in chronic bronchitis – studies in vivo and in vitro
• New systems for exposing human 3D-models of airway mucosa in health and disease to particulate- and gaseous air pollutants
• Detailed study on Toll-like receptor (TLR) mediated immune and pro-inflammatory response to carbon nanoparticle exposure in vitro