Neurofibromatosis, Tuberous Sclerosis, and other genetic syndromes – prevalence, risk factors for sporadic occurrence, comorbidities, and mortality

Genetic syndromes such as neurofibromatosis type 1 and type 2, Von Hippel-Lindau disease, tuberous sclerosis complex, and other phacomatoses are known risk factors for nervous system tumors and other malignancies.

The phacomatoses are autosomal dominant disorders; however, a large proportion of patients are de novo with no previous family history of the disease. The most common phacomatosis is neurofibromatosis type 1 with an estimated prevalence at birth of 1/3000.

We have unique possibilities to contribute important well-designed epidemiological studies on phacomatoses through the Swedish health data registers, which allows us to identify the outcomes, link children, parents and siblings, obtain information on perinatal factors, including also parental occupations, prescribed drugs, morbidity and mortality. Importantly, we will be able to distinguish between sporadic (de novo) and inherited cases, and the long history of the Swedish population-based health data registers allows us to identify the hitherto largest cohort of phacomatoses.

This research program on phacomatoses consists of three different parts; one focused on the association between phacomatoses and perinatal factors and whether phacomatoses could explain the previously observed association between perinatal factors and childhood cancer risk, a second part focused on the prevalence at birth of phacomatoses and studies regarding comorbidities and excess mortality among individuals affected by these genetic syndromes, and a third part will investigate potential risk factors for de novo phacomatoses, such as parental age and parental occupational exposures.


Swedish Cancer Society (Cancerfonden)

Swedish Research Council for Health, Working Life and Welfare (FORTE)

Swedish Research Council (VR)


Giorgio Tettamanti

Assistant professor


Maternal smoking during pregnancy and risk of phacomatoses: results from a Swedish register-based study.
Tettamanti G, Mogensen H, Nordgren A, Feychting M
Clin Epidemiol 2019 ;11():793-800

Parental age and risk of genetic syndromes predisposing to nervous system tumors: nested case-control study.
Adel Fahmideh M, Tettamanti G, Lavebratt C, Talbäck M, Mathiesen T, Lannering B, et al
Clin Epidemiol 2018 ;10():729-738