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Identification and assessment of reproductive toxicity and endocrine disruption

Course dates

The course is given every second year. The last course was on November 25-29, 2013. Next course dates will be announced here later.

Course organiser

The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM in collaboration with the Doctoral programme Environmental Factors and Health (EFH) at Karolinska Institutet, course number 2487 and the Executive and Professional Education Office at Karolinska Institutet.

Course credits

The course corresponds to 1.5 ECTS credits.

Learning outcomes

After the course the participant shall be able to: describe and discuss methods and procedures used in health risk assessment of reproductive toxicity and endocrine disrupters, as well as of the limitations involved, and demonstrate a professional attitude towards interpretation of toxicological and epidemiological studies of reproductive and endocrine toxicity for use in health risk assessment.


The course will include fundamental concepts in reproductive and developmental toxicity. Special attention will be paid to the endocrine toxicity mode-of-action. The course will cover complexities/difficulties in risk assessment and risk management including regulatory decision-making. Standardized test guidelines of reproductive and endocrine disrupting effects will be covered. Specific attention will be given to the development of test strategies in endocrine disrupting chemicals within the field. Attention will be paid to interpretation possibilities and evaluation of data from different test systems, handling of uncertainties and data gaps, and other problems in health risk assessment of reproductive toxicity and endocrine disruption. Particular focus will be given to identification of critical effects, extrapolation to humans and sensitive groups, application of assessment factors and allocation of health-based guidance values. Suggested limitations for EDCs in general risk assessment procedures will be discussed, e.g. shape of dose-response curve and epigenetic effects. Specific risk assessments of problematic chemicals will be discussed.

Teaching and learning activities

The course consists of lectures, group work and group work presentations.

Course programme

The course programme for the previous course on November 25-29, 2013 is available here.

The course is intended for

PhD students and other participants from academia as well as participants from authorities and industry.

Course fee

There is no course fee for PhD students. The fee for participants from academia (except PhD students), from authorities and from industry will be announced later. Course fee includes course material, coffee breaks and a get together reception. Payment of course fee can only be accepted from the participant’s employer, not from individuals.

The participants must cover their costs for travel and accommodation.

Course application

Information on application procedure to the next course will be available later.

Course leaders

Johanna Zilliacus and Annika Hanberg, Institute of Environmental Medicine, Karolinska Institutet.



Johanna Zilliacus

Telefon: 08-524 835 44
Enhet: Biokemisk toxikologi