Health risk assessment of reproductive toxicity and endocrine disruptors
September 24-28, 2018.
The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM in collaboration with the Doctoral programme Environmental Factors and Health (EFH) at Karolinska Institutet, course number 2933 and the Executive and Professional Education Office at Karolinska Institutet.
The course corresponds to 1.5 ECTS credits.
After the completion of the course the student should be able to:
- describe the principles for health risk assessment of reproductive toxicity
- explain how different types of data from in vivo, epidemiological and in vitro studies are used for health risk assessment of reproductive toxicity
- identify and discuss complexities in health risk assessment of reproductive toxicity
- identify and discuss complexities in health risk assessment of endocrine disruptors
Reproductive toxicity describes toxic effects of a chemical substance on the reproductive ability as well as on the development of the offspring. Health risk assessment of reproductive toxicity addresses the procedures to identify and characterise the reproductive toxicity with the aim to derive health based guidance values for safe levels of the chemical substances. Endocrine disruptors are substances that alter the endocrine system and are a special concern for risk assessment of reproductive toxicity. The course introduces the concepts in reproductive toxicity as well as of endocrine disruptors. Methods for identification and assessment of reproductive toxicity are described and discussed. Regulatory aspects of reproductive toxicity and endocrine disruption will be covered. Attention will be paid to evaluation of different type of data. Specific challenges in risk assessment of reproductive toxicity and of endocrine disruptors such as non-monotone dose response curves, low-dose effects and epigenetic mechanisms will be discussed.
Teaching and learning activities
The course includes lectures, exercises and group assignments.
The course programme will be available later.
The course is intended for
PhD students and other participants from academia as well as participants from authorities and industry.
The fee for participants from academia (including PhD students) is 300 euro, from authorities 600 euro and from industry 900 euro, including VAT. Course fee includes course material and coffee breaks. Payment of course fee can only be accepted from the participant’s employer, not from individuals.
The participants must cover their costs for travel and accommodation.
Course application form. Application deadline is 28 July, 2018. Accepted participants will be notified after the application deadline.
Johanna Zilliacus, Annika Hanberg and Anna Beronius, Institute of Environmental Medicine, Karolinska Institutet.