Computer modeling of toxicokinetics and cellular signaling pathways
The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM in collaboration with the Doctoral programme Environmental Factors and Health at Karolinska Institutet, course number 2208.
The course corresponds to 1.5 ECTS credits.
After the course, the students should understand and be able to apply basic principles in toxicokinetic (TK), including physiologically based pharmacokinetic (PBPK) and toxicodynamic (TD) modeling. Further, they should be aware of modeling techniques for quantitative investigation of how biological systems respond to perturbations at the cellular level and of the biological circuits that control these responses.
The course will cover the following major topics: - Basic TK, PBPK and TD concepts. - Issues in model development and validation including sensitivity analysis, uncertainty and variability, Monte Carlo simulation. - Approaches to modeling biological response pathways including homeostasis, adaptation, threshold response, binary cell fate decisions, and irreversible differentiation. - Applications of TK, PBPK, TD and biological systems modeling in toxicological risk assessment.
Teaching and learning activities
This one-week full time course consists of daily lectures and daily computer exercises. Dr. Melvin Andersen from The Hamner Institutes of Health Sciences, Research Triangle Park, North Carolina, USA is one of the main teachers at the course.
The course programme for the previous course on May 13-17, 2013 is available here.
The course is intended for
PhD students and post docs as well as participants from authorities and industry.
There is no course fee for PhD students. The fee for participants from academia (except PhD students), from authorities and from industry will be announced later. Course fee includes course material, coffee breaks and a get together reception. Payment of course fee can only be accepted from the participant’s employer, not from individuals.
The participants must cover their costs for travel and accommodation.
Information on application procedure to the next course will be available later.
Gunnar Johanson, Institute of Environmental Medicine, Karolinska Institutet.