Trauma and sepsis research in critical care and beyond - TRASH

Trauma and sepsis are common causes for intensive care admission. These conditions are closely linked and carry high mortality. We are conducting translational studies ranging from epidemiology to in vitro experiments in this field.

Trauma is leading cause of death for individuals under the age of 45. We are conducting epidemiological studies on various aspects of trauma including risk factors, outcomes and long-term consequences of this devastating disease. Our group is also studying the serious complications encountered in intensive care of trauma victims such as multiple organ failure and sepsis. These studies also include dynamics of biomarkers induced by severe trauma and sepsis. 

Sepsis is causes more than 5 million deaths annually and remains a major challenge to the medical profession. We are conducting epidemiological studies on risk factors, magnitudes and outcomes of this lethal condition. We are also performing experimental studies on pathophysiological aspects mainly regarding endothelial dysfunction, a major component in the development of septic shock.

Group members

Former group members:

  • Patrik Rossi, MD, PhD, former doctoral student
  • David Konrad, MD, PhD, former doctoral student
  • Michael Wanecek, MD, PhD, former doctoral student and co-supervisor

    Publications

    Comparison of the sepsis-2 and sepsis-3 definitions in severely injured trauma patients.
    Eriksson J, Eriksson M, Brattström O, Hellgren E, Friman O, Gidlöf A, et al
    J Crit Care 2019 Dec;54():125-129

    Predicting prolonged sick leave among trauma survivors.
    von Oelreich E, Eriksson M, Brattström O, Discacciati A, Strömmer L, Oldner A, et al
    Sci Rep 2019 01;9(1):58

    Effect of preadmission beta-blockade on mortality in multiple trauma.
    Eriksson M, von Oelreich E, Brattström O, Eriksson J, Larsson E, Oldner A
    BJS Open 2018 Dec;2(6):392-399

    Heparin-binding protein as a biomarker of post-injury sepsis in trauma patients.
    Halldorsdottir HD, Eriksson J, Persson BP, Herwald H, Lindbom L, Weitzberg E, et al
    Acta Anaesthesiol Scand 2018 08;62(7):962-973

    Post-trauma morbidity, measured as sick leave, is substantial and influenced by factors unrelated to injury: a retrospective matched observational cohort study.
    von Oelreich E, Eriksson M, Brattström O, Discacciati A, Strömmer L, Oldner A, et al
    Scand J Trauma Resusc Emerg Med 2017 Oct;25(1):100

    Thioredoxin a novel biomarker of post-injury sepsis.
    Eriksson J, Gidlöf A, Eriksson M, Larsson E, Brattström O, Oldner A
    Free Radic. Biol. Med. 2017 03;104():138-143

    Causes of excessive late death after trauma compared with a matched control cohort.
    Eriksson M, Brattström O, Larsson E, Oldner A
    Br J Surg 2016 Sep;103(10):1282-9

    Acute kidney injury following severe trauma: Risk factors and long-term outcome.
    Eriksson M, Brattström O, Mårtensson J, Larsson E, Oldner A
    J Trauma Acute Care Surg 2015 Sep;79(3):407-12

    Socio-economic status and co-morbidity as risk factors for trauma.
    Brattström O, Eriksson M, Larsson E, Oldner A
    Eur. J. Epidemiol. 2015 Feb;30(2):151-7

    Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?
    Persson BP, Halldorsdottir H, Lindbom L, Rossi P, Herwald H, Weitzberg E, et al
    Acta Anaesthesiol Scand 2014 May;58(5):549-59

    Clinical review is essential to evaluate 30-day mortality after trauma.
    Ghorbani P, Falkén M, Riddez L, Sundelöf M, Oldner A, Strömmer L
    Scand J Trauma Resusc Emerg Med 2014 Mar;22():18

    High incidence of post-injury pneumonia in intensive care-treated trauma patients.
    Hyllienmark P, Brattström O, Larsson E, Martling CR, Petersson J, Oldner A
    Acta Anaesthesiol Scand 2013 Aug;57(7):848-54

    Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?
    Johansson J, Brattström O, Sjöberg F, Lindbom L, Herwald H, Weitzberg E, et al
    Acta Anaesthesiol Scand 2013 May;57(5):580-6

    Time dependent influence of host factors on outcome after trauma.
    Brattström O, Larsson E, Granath F, Riddez L, Bell M, Oldner A
    Eur. J. Epidemiol. 2012 Mar;27(3):233-41

    Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment.
    Andersson A, Rundgren M, Kalman S, Rooyackers O, Brattstrom O, Oldner A, et al
    Br J Anaesth 2012 Feb;108(2):254-61

    Impact of sepsis on levels of plasma cystatin C in AKI and non-AKI patients.
    Mårtensson J, Martling CR, Oldner A, Bell M
    Nephrol. Dial. Transplant. 2012 Feb;27(2):576-81

    Endotoxin induces differentiated contractile responses in porcine pulmonary arteries and veins.
    Persson BP, Boels PJ, Lövdahl C, Rossi P, Arner A, Oldner A
    J. Vasc. Res. 2011 ;48(3):206-18

    Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury.
    Mårtensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR
    Intensive Care Med 2010 Aug;36(8):1333-40

    Early predictors of morbidity and mortality in trauma patients treated in the intensive care unit.
    Brattström O, Granath F, Rossi P, Oldner A
    Acta Anaesthesiol Scand 2010 Sep;54(8):1007-17

    Inhaled tezosentan reduces pulmonary hypertension in endotoxin-induced lung injury.
    Persson BP, Rossi P, Weitzberg E, Oldner A
    Shock 2009 Oct;32(4):427-34

    Left ventricular mechanical dyssynchrony is load independent at rest and during endotoxaemia in a porcine model.
    A'roch R, Steendijk P, Oldner A, Weitzberg E, Konrad D, Johansson G, et al
    Acta Physiol (Oxf) 2009 Aug;196(4):375-83

    Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction.
    Rossi P, Persson B, Boels PJ, Arner A, Weitzberg E, Oldner A
    Intensive Care Med 2008 May;34(5):873-80

    Cardiac effects of endothelin receptor antagonism in endotoxemic pigs.
    Konrad D, Haney M, Johansson G, Wanecek M, Weitzberg E, Oldner A
    Am. J. Physiol. Heart Circ. Physiol. 2007 Aug;293(2):H988-96

    Financial support

    • European Society of Intensive Care Medicine
    • Stockholm County Council
    • Carnegie Foundation
    • Magnus Bergvall Foundation
    • Laerdal Foundation
    • Swedish Society of Medicine
    • Swedish Cancer and Traffic Injury Society Fund 
    • LPS Medical Foundation

    Contact us

     

    Anders Oldner

    Adjunct Professor, Group leader