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Anesthetic neuropharmacology and physiology

Our group study neuroinflammation and longterm neurocognitive decline after surgery or trauma.

Surgery is closely associated with longterm neurocognitive impairment, a condition also known as postoperative cognitive dysfunction (POCD).

Our translational project explore mechanisms, pathophysiology, prevention and long-term outcome of surgery-induced neuroinflammation with postoperative neurocognitive disorders and dementia. Using comprehensive clinical and experimental platforms in animals and cells, combined with translational studies in surgical patients and nationwide outcome studies, our group identify and describe key mechanisms and at-risk patients for postoperative neurocognitive decline or dementia.

We investigate surgery-induced immune activation, neuronal function in cognitive processing and immune activation in relation to long term brain dysfunction and systemic inflammation in animal and cell models. We translate experimental findings to humans by application of state-of-the-art brain PET-imaging, cerebrospinal fluid neurochemistry, cognitive test batteries with advanced pattern recognition analysis of systemic immune system in surgical patients to explore the association between trauma-induced changes in brain and systemic immune systems and later neurocognitive decline.

Clinical results are combined with nationwide outcome studies on the impact of surgery or trauma on later cognitive performance and dementia aiming to identify at-risk patients to define novel therapeutic strategies.

Group members

Funding

  • VR Medicine
  • The Brain Foundation
  • Region Stockholm ALF project grant
  • European Society for Anesthesiology
  • Swedish Medical Society
  • Swedish Society for Anesthesia and Intensive Care

    Selected publications

    State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.
    Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, et al
    Br J Anaesth 2019 10;123(4):464-478

    Days at Home after Surgery: An Integrated and Efficient Outcome Measure for Clinical Trials and Quality Assurance.
    Bell M, Eriksson LI, Svensson T, Hallqvist L, Granath F, Reilly J, et al
    EClinicalMedicine ;11():18-26

    Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.
    Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al
    Anesth. Analg. 2018 11;127(5):1189-1195

    Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group
    Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Amgst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang D-S, Wei H, Xie Z, Zuo Z
    Anesthesia & Analgesia: December 2018 - Volume 127 - Issue 6 - p 1406-1413

    Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.
    Mkrtchian S, Lee KL, Kåhlin J, Ebberyd A, Poellinger L, Fagerlund MJ, et al
    Adv. Exp. Med. Biol. ;1071():25-33

    Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery.
    Femenía T, Giménez-Cassina A, Codeluppi S, Fernández-Zafra T, Katsu-Jiménez Y, Terrando N, et al
    J. Neurosci. 2018 01;38(2):452-464

    Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
    Glatz P, Sandin RH, Pedersen NL, Bonamy AK, Eriksson LI, Granath F
    JAMA Pediatr 2017 Jan;171(1):e163470

    Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.
    Zhang MD, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, et al
    Proc. Natl. Acad. Sci. U.S.A. 2016 10;113(43):E6686-E6695

    Neural Control of Inflammation: Implications for Perioperative and Critical Care.
    Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS
    Anesthesiology 2016 May;124(5):1174-89

    The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.
    Kåhlin J, Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, et al
    Exp. Physiol. 2014 Aug;99(8):1089-98

    Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline.
    Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, et al
    FASEB J. 2013 Sep;27(9):3564-71

    Resolving postoperative neuroinflammation and cognitive decline.
    Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, et al
    Ann. Neurol. 2011 Dec;70(6):986-995

    Contact

    Lars I Eriksson

    Professor/senior physician