Regeneration of the oral mucosa
Research projects are focused on examining the regenerative capacity of soft connective tissues within the oral cavity during health and disease.
We are particularly concerned with the complications that result following hematopoietic stem cell transplantation in the form of Graft versus Host Disease. Oral manifestations are one of the most common and debilitating complications, and the histopathology poorly understood. The oral cavity has a huge potential to heal without scaring and many sources of stem cells have been identified in the soft tissues, including, gingivia, labial and buccal mucosal.
A key to harnessing the cells potential and facilitating novel treatment strategies for cGVHD is to understand the stem cell niche and the role of the extracellular matrix (ECM) in maintaining this niche supporting the reparative process. Thus, research is also focusing on the role of the ECM in supporting the resident fibroblast and stem cell niche during wound healing and tissue repair, and regeneration of these tissues.
Patient with severe oral chronic GVHD lichenoid lesion
- Rachael Sugars, Lecturer
- Karin Garming-Legert, Lecturer
- Victor Tollemar Wilmenius, Student
- Nikocle Tudzarovski, Research assistant
Collaborators and additional projects:
- Gunnar Warfvinge (Malmö Dental School), Robert Heyman (Image and Functional Odontology)
- Gregory Tour, postdoc, Department of Laboratory Medicine, KI
- Katarina Le Blanc, Department of Medicine, KI