Prediction of disease activity and TMJ involvement in patients with JIA
Project: Prediction of disease activity and TMJ involvement in patients with JIA
Juvenile idiopathic arthritis (JIA) is a chronic, systemic disease in children characterized by recurrent autoimmune inflammations affecting the joints and other structures. Approximately 55% of patients with JIA have at least one symptom or sign of TMJ arthritis and 62-78% show radiographic lesions on the condyles. Inhibition of the TMJ condylar growth resulting in micrognathia is a severe negative functional and aesthetic consequence to arthritis and may occur in addition to pain, functional limitation and cartilage and bone tissue destruction. It is currently not possible to diagnose individual patients at risk for growth disturbances or long-term arthritis.
The general aim of this project is to improve the diagnostic methods for disease activity and identify predictive factors (clinical and radiographic factors, pro- and anti-inflammatory mediators in saliva and plasma) for TMJ involvement in JIA.
- Malin Collin, PhD student
Academic collaboration: Assistant professor Nikoalos Christidis, DDS, PhD (co-supervisor); Professor Malin Ernberg, DDS, PhD (co-supervisor), both at KaroIinska Institutet, Huddinge, Sweden; Associate Professor Stefan Hagelberg MD, PhD, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital, Stockholm, Sweden (co-supervisor).
Folktandvården AB, the Swedish Rheumatism Association, and the Swedish Dental Society.