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Ustekinumab (Stelara)

Ustekinumab is a human monoclonal antibody used to treat psoriasis, psoraitic arthritis and Crohn’s disease.

It blocks interleukin IL-12 and IL-23, which help activate certain T-cells, by binding to the p-40 subunit of both IL-12 and IL-23 so that they subsequently cannot bind to their receptors.

It is administered through subcutaneous injection every 8 weeks.

In 2016, it sold €572 million in Europe.

It has an immunogenicity rate of 1-11%.

Labs that test for drug level:

Karolinska University Lab
KU Leuven
United Medix Labs

Labs that test for ADA titre:

KU Leuven
United Medix Labs