University of Tours, Tours, France
The PATCH team (PhArmacology of TherapeutiC antibodies in Human) studies the sources of variability of response to therapeutic antibodies, both in terms of efficacy and adverse side effects. In this field, the team evaluates individual factors that may influence drug pharmacokinetics and their concentration-effect relationship in humans. The team is also studying response biomarkers in an integrative way, using a Quantitative Systems Pharmacology approach applied to pharmacokinetic-pharmacodynamic (PK-PD) modelling.
The works of the laboratory covers all therapeutic antibodies and therefore concerns
- Oncology- colon, breast, and lymphomas
- Immunoinflammatory diseases- rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel diseases
- Other pathologies treated by biopharmaceuticals- hereditary haemorrhagic telangiectasia and haemolytic-uremic syndrome.
ELISA: Measure drug concentrations of monoclonal antibodies and other biopharmaceuticals in serum and other biological fluids: