Lena Flyckt´s research group

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Clinical and translational research of schizophrenia and psychoses

Schizophrenia is a disease that affects young people and leads to a chronic disease course with severe symptoms and impaired functioning. Research at Karolinska Institutet have shown a correlation between the disease and signs of neuro-inflammation.

Stockholm Network for Translational Schizophrenia Research aims to study the signs of inflammation in patients, first diagnosed with schizophrenia spectrum disorder. They are recruited at three psychiatric hospitals and offered to undergo a thorough clinical, neurocognitive and neurological examination by neuroimaging, cognitive, genetic and electrophysiological methods. The overall aim is to study neuro-inflammation as a possible pathogenetic mechanism underlying the symptoms and functional impairments that characterize schizophrenia.

Other objectives are to identify risk factors, genetic and environmental, that contribute to the development and onset of schizophrenia, and finally to find compounds that are suitable for drug development targeting neuro-inflammation.

Stockholm Research Network for schizophrenia research has a steering group, Professor Lena Flyckt, Professor Lars Farde and Professor Göran Engberg, but also includes a large number of senior researchers, four graduate students and two postdocs.

Research projects

  • Neuroimmunaktivering, en mekanism bakom schizofreni?
  • Den subjektiva och objektiva närstående bördan vid schizofreni
  • Maternell nedärvning av patologisk tyrosintransport over plasmamembran vid schizofreni
  • Prediktion av långtidsförlopp hos förstagångsinsjuknade psykospatienter

Selected Publications

Aberrant tyrosine transport across the fibroblast membrane in patients with schizophrenia--indications of maternal inheritance.
Flyckt L, Edman G, Venizelos N, Borg K
J Psychiatr Res 2011 Apr;45(4):519-25

Predicting 5-year outcome in first-episode psychosis: construction of a prognostic rating scale.
Flyckt L, Mattsson M, Edman G, Carlsson R, Cullberg J
J Clin Psychiatry 2006 Jun;67(6):916-24

Kinetics of tyrosine transport and cognitive functioning in schizophrenia.
Wiesel F, Edman G, Flyckt L, Eriksson A, Nyman H, Venizelos N, et al
Schizophr. Res. 2005 Apr;74(1):81-9

Aberrant tyrosine transport across the cell membrane in patients with schizophrenia.
Flyckt L, Venizelos N, Edman G, Bjerkenstedt L, Hagenfeldt L, Wiesel F
Arch. Gen. Psychiatry 2001 Oct;58(10):953-8

Muscle biopsy, macro EMG, and clinical characteristics in patients with schizophrenia.
Flyckt L, Borg J, Borg K, Ansved T, Edman G, Bjerkenstedt L, et al
Biol. Psychiatry 2000 Jun;47(11):991-9

Group members

Joachim EckerströmGraduate Student
Helena Fatouros-BergmanAssociated
Lena FlycktAssociated, Research team leader
Cornelia LarssonGraduate Student
Kent-Inge PerseiusAssociated
Maria MattssonAssociated