Department of Neurology, Innsbruck Medical University, Innsbruck
This research group is working in the field of neuroimmunology with the following scientific interests: multiple sclerosis, neurological laboratory diagnostics, immune neuropathies and (together with the research group neurodegenerative diseases) on the role of glial cells in neurodegeneration.
Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven
The laboratory has a large expertise in the generation, characterization and application of monoclonal antibodies towards different targets. In-house generated antibodies have been used to develop immunoassays used to determine drug and anti-drug antibody concentrations. The aim is to improve the treatment of patients suffering from chronic inflammatory diseases such as inflammatory bowel diseases, psoriasis and rheumatic diseases.
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia
This labs research is focused on the quality of recombinant proteins produced in Escherichia coli. They are searching for the reasons causing structural instability and immunogenicity of therapeutic proteins and for ways how to overcome these problems. They discovered an unknown cause of protein drugs’ immunogenicity – the involvement of the proteins in the Maillard reaction (glycation) during their synthesis in the bacterial host.
United Medix Labs, Helsinki
United Medix Laboratories is a clinical central laboratory and analyses approx. 4 million tests annually within all branches of clinical laboratory analyses. Within the field of therapeutic drug monitoring the main aim is to provide drug level and anti-drug antibody analyses to help clinicians in personalizing use of biologicals.
University of Tours, Tours
The PATCH team studies the sources of variability of response to therapeutic antibodies, both in terms of efficacy and adverse side effects. In this field, it evaluates individual factors that may influence drug pharmacokinetics and their concentration-effect relationship in humans.
Laboratory of Biology Saint-Etienne Hospital
The Saint-Etienne University Hospital is one of the largest healthcare trusts in the region offering a full range of services. The hospital focuses on combining pioneering research, academic excellence and outstanding clinical care. To this extent this lab focuses on the diagnosis of immune related diseases such as autoimmunity, inflammation, allergy, cellular immunity, immune deficiency and follow up biotherapies.
INSERM UMR 996, Faculty of Pharmacy, University Paris -Saclay
The main task of this lab is to explore the mechanism of immunization to drugs. In the field of biotherapeutics, they develop and validate ADA assays using a MSD platform. They had developed an assay for infliximab and one for adalimumab that are working. A Nivolumab assay is under validation. They also aim at understanding the role of protein aggregates in the immunogenicity of these products by developing dendritic and T-cell assays.
Neurological Clinic, Heinrich-Heine University, Düsseldorf
This lab focuses mainly on clinical studies and BioBanking of human samples. As a collaborator of the ABIRISK-project, they performed the BAB-Elisa and Vitamin-D measurements as the main laboratory. They use a range of diagnostic methods, used to gain important information about the function and condition of the nervous system in the various neurological diseases.
Regional Multiple Sclerosis Centre, AOU San Luigi Gonzaga Orbassano, Turin
The laboratory deals with routine cerebrospinal fluid analysis and oligoclonal bands detection from AOU San Luigi Gonzaga patients and from several Piedmont centres. Additionally, detection of anti-Aquaporin 4 and anti-myelin oligodendrocyte glycoprotein antibodies on serum samples are performed for differential diagnosis with Neuromyelitis Optica Spectrum Disorders.
Inflammatory Bowel Disease Unit and Gastro-Immunology Laboratory, Sheba Medical Centre, Tel Aviv
Being the largest government hospital in Israel and serving more than 100,000 patients a year, Sheba Medical Centre is the responsible choice for medical treatment. It contains Gastro-Immunology Lab that researches into GI tract diseases and measures levels of biologics used to treat these diseases, and the ADAs against these therapies.
Sanquin produces plasma pharmaceuticals, develops blood group and immune reagents, performs a multitude of diagnostic services, conducts scientific research and provides education and training. Sanquin provides diagnostic services for blood transfusion and immunology.
Canterbury Health Laboratories (CHL), Christchurch
Canterbury Health Laboratories (CHL) is one of two tertiary level reference and teaching laboratories within New Zealand with capability and experience in providing a range of services. CHL employs over 400 staff, including experienced teams of medical laboratory scientists, technicians, scientific officers and clinicians, with expertise across all disciplines. Research and development is supported.
Institute of Biomedical Research in Malaga (IBIMA), Regional University Hospital, Málaga
This lab mainly focuses on research into Multiple Sclerosis. They are in search of new biomarkers in MS, assess immunogenicity of MS biologics, genetics and pharmacogenetics of the disease, immunological mechanisms, and stem cell therapy in patients with MS.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm
Karolinska Insitutet, Department of clinical Neuroscience, Centre for Molecular Medicine (CMM) is a research laboratory for immunogenicity that also provides testing for ADA against rituximab and natalizumab, ADA bound in immune complexes for infliximab and neutralizing ADA for interferon beta. We provide education and training, core facilities and internationally well established scientific research.
More information about the Department of Clinical Neuroscience
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Lab, Stockholm
Karolinska University Laboratory, Clinical Immunology and Transfusion medicine. This routine laboratory servers the hospital with all clinical tests needed, including drug levels for infliximab, adalimumab, etanercept and rituximab as well as ADA for infliximab and adalimumab.
More information about the Department of Clinical Immunology and Transfusion Medicine
Wieslab offers both routine clinical testing as well as a range of laboratory services for pharma, biotech and CRO customers.
Within clinical routine testing Wieslab specializes in autoimmunity assessment. they offer a comprehensive range of individual and panel tests. Wieslab strives to provide a complete decision-making base for the clinician to make the right diagnosis fast and to be able to implement the correct treatment strategies.