Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, Belgium
The laboratory for Therapeutic and Diagnostic Antibodies is a research laboratory affiliated with the Department of Pharmaceutical and Pharmacological Sciences of the KU Leuven in Belgium. The laboratory has a large expertise in the generation, characterization and application of monoclonal antibodies towards different targets. In-house generated antibodies have been used to develop immunoassays used to determine drug and anti-drug antibody concentrations. The laboratory served as analytical centre for drug and ADA measurements within several prospective clinical studies (e.g. TAXIT, TAILORIX, GOUDA).
They are a part of the Monitoring Monoclonal Antibodies Group Europe (MAGE) and the lab is a co-founder of PharmAbs, the KU Leuven Antibody Centre. PharmAbs is an innovation, incubation and valorization platform at KU Leuven, clustering the antibody expertise of five different KU Leuven groups with a mission to translate fundamental biomedical research carried out by universities into lead products for new medicines or into novel diagnostic solutions.
The laboratory collaborates with different hospitals in and out of Belgium. Their main collaborator is the University Hospital of Leuven (UZ Leuven) with whom they collaborate on the research of:
- Inflammatory Bowel Diseases (Department of Gastroenterology)
- Ankylosing Spondylitis and Rheumatoid Arthritis (Department of Rheumatology)
- Psoriasis (Department of Dermatology)
- Venous thrombosis in chronic inflammatory diseases (Department of Cardiovascular diseases).
Additionally, a collaboration has started with the Department of Dermatology of UZ Ghent.
To measure drug levels:
- Lateral flow technology
- Fibre optic Surface Plasmon Resonance analysis
To measure ADA titres:
- Drug sensitive bridging ELISA
- Drug tolerant bridging ELISA
- Drug tolerant Affinity Capture Elution assay (ACE)
- Precipitation and acid dissociation assay (PANDA)
- Cell based assay
Website link: http://pharm.kuleuven.be/biotech