Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, Belgium

​​​​​​​The laboratory for Therapeutic and Diagnostic Antibodies is a research laboratory affiliated with the Department of Pharmaceutical and Pharmacological Sciences of the KU Leuven in Belgium.

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The laboratory has a large expertise in the generation, characterization and application of monoclonal antibodies towards different targets. In-house generated antibodies have been used to develop immunoassays used to determine drug and anti-drug antibody concentrations. The laboratory served as analytical centre for drug and ADA measurements within several prospective clinical studies (e.g. TAXIT, TAILORIX, GOUDA).

They are a part of the Monitoring Monoclonal Antibodies Group Europe (MAGE) and the lab is a co-founder of PharmAbs, the KU Leuven Antibody Centre. PharmAbs is an innovation, incubation and valorization platform at KU Leuven, clustering the antibody expertise of five different KU Leuven groups with a mission to translate fundamental biomedical research carried out by universities into lead products for new medicines or into novel diagnostic solutions.

Diseases Researched:

The laboratory collaborates with different hospitals in and out of Belgium. Their main collaborator is the University Hospital of Leuven (UZ Leuven) with whom they collaborate on the research of:

  • Inflammatory Bowel Diseases (Department of Gastroenterology)
  • Ankylosing Spondylitis and Rheumatoid Arthritis (Department of Rheumatology)
  • Psoriasis (Department of Dermatology)
  • Venous thrombosis in chronic inflammatory diseases (Department of Cardiovascular diseases).

Additionally, a collaboration has started with the Department of Dermatology of UZ Ghent.

Performed Tests:

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Drugs tested:

  • Infliximab
  • Adalimumab
  • Etanercept
  • Golimumab
  • Vedolizumab
  • Ustekinumab
  • Secukinumab

To measure drug levels:

  • Lateral flow technology
  • Fibre optic Surface Plasmon Resonance analysis

To measure ADA titres:

  • Drug sensitive bridging ELISA
  • Drug tolerant bridging ELISA
  • Drug tolerant Affinity Capture Elution assay (ACE)
  • Precipitation and acid dissociation assay (PANDA)
  • Cell based assay

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