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Faculty of Pharmaceutical Sciences, Paris University, France

The main task of this lab is to explore the mechanism of chemical and drug allergy. In the field of biotherapeutics, they aim at understanding the role of protein aggregates in the immunogenicity of these products by developing dendritic and T-cell assays. They also develop and validate ADA assays using a MSD platform. They had developed an assay for infliximab and one for adalimumab that are working.

Diseases Researched:

The main diseases researched in this labs are;

  • Rheumatoid arthritis
  • Inflammatory bowel disease
  • In the future, different cancer indications

Performed Tests:

ADA titres:

  • Determines adalimumab and infliximab levels using Meso Scale Discovery (MSD)

Drug and ADA levels

  • Determines ADA against infliximab, etanercept, adalimumab, and rituximab using ELISA from Theradiag

Website link: http://umr996.inserm.fr/