Erik Jönsson's research group
Schizophrenia from a clinical and biological perspective - the Hubin project
The Hubin project brings together clinical and biological research aiming to find the pathology and etiology of schizophrenia. We examine patients with schizophrenia and related psychotic disorders and healthy volunteers with a comprehensive survey battery, which includes interviews, review of medical records, personality forms and neuropsychological tests. Subjects are also being investigated for neurological abnormalities, morphological magnetic resonance imaging (MRI) and genetic variation. Data pertaining monoamine metabolite concentrations in cerebrospinal fluid, minor physical anomalies and birth records exist for some of the subjects. Individuals who previously had undergone MRI are contacted for follow-up studies.
We work with groups in Denmark and Norway, using a similar research approach in order to increase the statistical power to examine issues of genes and other possible factors on schizophrenia and equally despised psychotic illnesses.
- Molecular genetic studies of monoamine metabolites in cerebrospinal fluid (likvor) in schizophrenics and healthy
- Follow up of patients and healthy subjects studied with MRI
- Molecular genetic association studies with candidate genes for schizophrenia
Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?
Suchankova P, Klang J, Cavanna C, Holm G, Nilsson S, Jönsson E, et al
J Psychiatry Neurosci 2012 Feb;37(2):122-8
Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls.
Haukvik U, Schaer M, Nesvåg R, McNeil T, Hartberg C, Jönsson E, et al
Psychol Med 2012 Jun;42(6):1329-37
Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
Tesli M, Koefoed P, Athanasiu L, Mattingsdal M, Gustafsson O, Agartz I, et al
Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011 Dec;156B(8):969-74
Genome-wide association study identifies five new schizophrenia loci.
Nat. Genet. 2011 Sep;43(10):969-76
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
Steinberg S, de Jong S, , Andreassen OA, Werge T, Børglum AD, et al
Hum. Mol. Genet. 2011 Oct;20(20):4076-81