Drug & ADA Kits

The discovery and availability of biopharmaceuticals over the last decade has advanced patient care globally. They provide highly effective, and specifically targeted treatment for a number of diseases. However, due to their complex structure, they elicit immunogenic responses in the body, through the production of anti-drug antibodies (ADAs). These ADAs can either bind the drug and neutralise its effects, or bind the drug and promote its clearance from the body. Both of these mechanisms result in secondary unresponsiveness in patients, leading to worsening of their disease. Despite this, many biopharmaceutical serum levels and ADA levels are not routinely tested in clinic. Our aim is to provide more accessible ways of assessing drug efficacy and immunogenicity. Below are a list of biologics and lab tests to measure drug serum levels and ADA serum levels.

Adalimumab

Drug level

ADA

Drug level and ADA

Labs that test for drug level:

Karolinska University Lab
University of Tours
KU Leuven
Sanquin

Labs that test for ADA titre:

Karolinska University Lab
Karolinska Institutet
KU Leuven
Sanquin
Sheba Medical Centre

Infliximab

Drug level

ADA

Drug level and  ADA

Labs that test for drug level: 

Karolinska University Lab
University of Tours
KU Leuven
Sanquin

Labs that test for ADA titre: 

KU Leuven
Sanquin
Sheba Medical Centre

Labs that test for immune complexes:

Karolinska Institutet

Etanercept

Drug level

ADA

Drug level and ADA

Labs that test for drug level: 

Karolinkska Univeristy Lab
University of Tours
KU Leuven

Labs that test for ADA titre: 

KU Leuven
Karolinska Institutet

Rituximab

Drug level

ADA

Labs that test for drug level: 

Karolinska University Lab
University of Tours
San Luigi Gonzaga University Hospital

Labs that test for ADA titre: 

Karolinska Institutet
San Luigi Gonzaga 

Interferon-β

Drug level and ADA

Labs that test for drug level: 

Bulgarian Academy of Science
San Luigi Gonzaga University Hospital

Labs that test for ADA titre: 

Karolinska Institutet
Innsbruck Medical University
San Luigi Gonzaga University Hospital
Bulgarian Academy of Science
IBIMA

Natalizumab

Drug level

ADA

Labs that test for drug level: 

Innsbruck Medical University
​Sanquin

Labs that test for ADA: 

Karolinska Institutet
Innsbruck Medical University
San Luigi Gonzaga University Hospital
IBIMA
Sanquin

Basiliximab

Drug level

ADA

Labs that test for drug level:

University of Tours

Eculizumab

Drug level

ELISA Kit - order at: https://www.4adi.com/

ADA

ELISA Kit - order at: https://www.biotrend.com/

Labs that test for drug level:

University of Tours

Tocilizumab

Drug level

Reference standard for ADA bridging

Labs that test for drug level:

University of Tours
Sanquin
United Medix Lab

Labs that test for ADA level:

Sanquin
United Medix Lab

Cetuximab

Drug level

Reference standard for ADA bridging

Labs that test for drug level:

University of Tours

Panitumumab

Reference standard for ADA bridging

ELISA Kit - order at: https://www.bio-rad-antibodies.com/

Labs that test for drug level:

University of Tours