Division of Eye and Vision
The Division of Eye and vision which is located at St. Erik Eye Hospital, conducts education at the undergraduate, advanced and postgraduate levels, as well as research with the aim of developing the eye care of the future.
Menu for this area
Research seminars and dissertations
Research seminars
May 14, Research seminar - Research group Kvanta/André
Latest news
Research grant for a doctoral position from Promobilia
Yiting Wang has been awarded a research grant for a doctoral position by the Promobilia Foundation (Doctoral Fellowship) amounting to 1 450 000 SEK. The grant covers a period of two years with the possibility of extension for an additional two years with the same amount.
Yiting Wang is an engineer in electrical and computer engineering, specializing in machine learning and AI. In this project, we will explore the possibility that so-called fixational eye movements and microsaccades – a type of very small, rapid, and involuntary eye movements that are relatively unexplored in clinical contexts – may carry information about brain health that can help us detect symptoms of early-stage Parkinson's disease.
Generous donation to eye research at KI
The Ulla and Ingemar Dahlberg Foundation has decided to donate SEK 50 million to Karolinska Institutet. The grant will be used for a new professorship in vision science with a focus on ocular neurobiology and have the full name "Ulla och Ingemar Dahlbergs professur i synvetenskap med inriktning mot okulär neurobiologi" (Ulla and Ingemar Dahlberg's Professorship in Visual Science with specialization in Ocular Neurobiology).
"It's an incredibly important and welcome donation. KI generally has a relatively small number of professors in ophthalmology, so this addition will make a big difference to eye research in Sweden," says Rune Brautaset, professor at the Department of Clinical Neuroscience and head of the Division of Eye and Vision.
KI Innovations brings in 6 new companies into the incubator - strengthening in Medtech and drug development
KI Innovation's Deeptech incubator DRIVE expands its portfolio by bringing in six new companies with a focus on the development of pharmaceuticals, cell therapies, diagnostics and Medtech products. With the right support, the accepted companies all have great potential to contribute to the benefit of society. Pete Williams and Melissa Jöe from Pete Williams' research group with Mim Neuroscience are one of the selected companies.
Physiological optics
He looks at brain disorders through the retina
With the help of OCT analysis, there is a simple and inexpensive way of examining the eyes in order to monitor the progression of disease and effect of treatment in people with multiple sclerosis (MS).
We can do this since loss of nervous tissue in the brain is reflected in the retina, says Optometrist and researcher Rune Brautaset who uses OCT for his research.
Physiological optics
Repeatability of a fully automated swept-source optical coherence tomography biometer and agreement with a low coherence reflectometry biometer
In conclusion, our results demonstrate that the Eyestar 900 and Lenstar LS 900 provide repeatable measurements for the different parameters analyzed. Comparing the instruments, we believe that despite the statistically significant differences reported in CCT and LT and the LoA values, we consider them negligible from a clinical standpoint. Hence, the two biometers can be used interchangeably.
The integrity of psychophysical visual function in non-immunocompromised PLHIV (NIPLHIV) without retinitis on antiretroviral therapy (ART)
The present study investigated the integrity of contrast sensitivity (CS), colour vision, and pattern evoked vision potentials (VEP) in non-immunocompromised people living with HIV (NIPLHIV) without retinitis.
The Integrity of Retinal Morphology in Non-immunocompromised People Living with HIV on Antiretroviral Therapy
Macula thickness and volumetric differences do exist in NIPLHIV. Practitioners should keep NIPLHIV under retinal morphometric surveillance because they live longer. Associations of cerebral atrophy with retinal morphology may be used to monitor cerebral atrophy in NIPLIV on ART.
Retina
KI researchers Anders Kvanta and Fredrik Lanner awarded a SEK 10 million grant
The Erling-Persson Foundation has awarded Anders Kvanta, professor at the Department of Clinical Neuroscience, Karolinska Institutet, and Fredrik Lanner, senior researcher at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet, a research grant of SEK 10 million extending over three years.
Doctoral funding from KI strengthens research on lack of oxygen in the eye tissue
Research group leader Helder André at St. Erik Eye Hospital and Karolinska Institutet has been awarded funds from KI's special grant for training a doctoral candidate. The funding enables the employment of a doctoral student for the project The translational role of hypoxia in blinding neovascular diseases for four years.
Transplantation of vision cells made from embryonic stem cells can restore lost vision
A new study published in the scientific journal Molecular Therapy, shows that transplanted vision cells made from embryonic stem cells can restore vision.
Ocular Oncology and Pathology
Ocular Oncology and Pathology
Gustav Stålhammar, nominated as one of the emerging and promising young researchers from the Nordic countries.
Acta Board have been nominated Gustav Stålhammar as one of the emerging and promising young researchers from the Nordic countries.
followed by a session with four young speakers from the Scandinavian countries, each of whom will talk about their own research. We invite you to be one of these speakers.
On the occasion of the 100th of Acta anniversary in Maastricht in June, Gustav is invited together with Joni Turunen, Finland och Cecilie Bredrup, Norway to speak about their own research.
Title of Gustavs lecture is: ”Uveal melanoma past, present, and future -Towards adjuvant treatment”
Overrepresentation of human epidermal growth factor receptor 2 positive- and Luminal B breast cancer metastases in the eyes and orbit
Vi visar att 4 av 5 bröstcancermetastaser i ögonen och orbita är av typen Luminal B, och att fler än hälften är positiva för HER2.
Vidare ser vi även att subtypen av bröstcancer ofta ändras mellan primärtumören i bröstet och metastasen i ögat.
Study confirms inflammation of the eye with glaucoma
A study at St Erik Eye Hospital and Karolinska Institutet is now able to confirm that inflammation of the retina and optic nerve occurs in patients with glaucoma. The results are published in the journal Acta Neuropathologica Communications.
Ocular Oncology and Pathology
Prognostic implications of tenascin C in peripheral blood and primary tumours at the time of uveal melanoma diagnosis
To examine the prognostic implication of tenascin C (TNC) in posterior uveal melanoma (UM).
Conclusions: TNC is a prognostic biomarker in UM. At the time of primary tumour diagnosis, it is measured in higher levels in both peripheral blood and tumour tissue from patients who will eventually suffer from metastatic death.
The prognostic implication of visual acuity at the time of uveal melanoma diagnosis
What was known before
Visual outcomes after treatment of uveal melanoma have been investigated repeatedly. Surprisingly few studies have examined the correlation between visual acuity before primary tumour treatment with long-term patient outcomes.
What this study adds
In a cohort of 1809 patients, we find that uveal melanoma patients with low visual acuity before treatment have greater incidence of uveal-melanoma-related mortality in competing risk analysis, and that they have shorter overall survival. This is likely related to the fact that patients with low visual acuity had significantly larger tumours. In the second cohort with 137 enucleated eyes, however, there were no significant relations between low visual acuity and any one of 13 examined tumour histological factors at a Bonferroni-corrected significance level.
Delays Between Uveal Melanoma Diagnosis and Treatment Increase the Risk of Metastatic Death
Increasing time between diagnosis and treatment of uveal melanoma is associated with a higher risk of metastatic death. These results challenge a central concept in the understanding of metastatic progression and may indicate the existence of late metastatic seeding. They also underscore the importance of prompt treatment. Validation in independent cohorts is recommended.
Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression
Four basic cell types can be outlined in uveal melanoma progression: normal, spindle A and B, and epithelioid. Differential expression of tumor suppressors, growth factors, and immune checkpoints could contribute to their relative over- and underrepresentation in benign, primary tumor, and metastatic samples.
Eye movements and vision
A novel view on the role of vision in brain injury
Each year tens of thousands of Swedes suffer from concussion. Some of them experience persistent difficulties, such as brain fatigue, sensitivity to light, headache and problems focusing. Optometrist and Research Group Leader Tony Pansell researches the benefits of spectacle treatment and vision therapy in this context.
Eye movements and vision
Vision impairment is common in non-hospitalised patients with post-COVID-19 syndrome
Vision-related symptoms and impairments were prevalent in the study group. The Developmental Eye Movement Test and the Visual Motion Sensitivity Clinical Test Protocol showed promise for clinical assessment of saccadic performance and sensitivity to movement in the environment. Further study will be required to explore the utility of these tools.
Translation and validation of a Swedish version of the Visual Vertigo Analogue Scale
The present study aimed to construct and validate a Swedish translation (VVAS-S) of the Visual Vertigo Analogue Scale (VVAS).
The Swedish version of the Visual Vertigo Analogue Scale is a questionnaire suitable for evaluating visually induced dizziness in a Swedish population. This study found that the Swedish questionnaire was comparable to the original in terms of internal consistency. The Swedish Visual vertigo Analogue Scale can be found as an appendix to this article.
Concussed patients with visually induced dizziness exhibit increased ocular torsion and vertical vergence during optokinetic gaze-stabilization
Visually Induced Dizziness (VID) is a common post-concussion sequalae that remains poorly understood and difficult to quantify. The present study aims to identify biomarkers for VID in the form of gaze-stabilizing eye movements. Nine patients with post-commotio VID and nine age-matched healthy controls were recruited by physiotherapists at a local neurorehabilitation centre.
In conclusion, post-commotio VID was associated with faster slow-phases during optokinetic gaze-stabilization, with both vergence and torsion being correlated to symptom intensity. As torsional tracking remains inaccessible using commercial eye-trackers, vertical vergence may prove particularly accessible for clinical utility.
Glaucoma
Glaucoma
Pete Williams is awarded 3 MSEK from StratNeuro for eye treatment with nanotechnology
Pete Williams, associate professor and research group leader at Karolinska Institutet and St. Erik Eye Hospital, has been awarded 3 MSEK from the Strategic Research Area Neuroscience (StratNeuro) at Karolinska Institutet to develop methods for delivering neuroprotective drugs to the eye using nanocarriers.
Broad overview published on strategies to protect neurons in glaucoma
James Tribble, Assistant Professor at Karolinska Institutet and St. Erik Eye Hospital, has written an overview article with colleagues in Australia and Canada on how research into new glaucoma treatments is progressing.
Study confirms inflammation of the eye with glaucoma
A study at St Erik Eye Hospital and Karolinska Institutet is now able to confirm that inflammation of the retina and optic nerve occurs in patients with glaucoma. The results are published in the journal Acta Neuropathologica Communications.
Glaucoma
Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for LHON. Oral nicotinamide provides a robust neuroprotective effect against mitochondrial and metabolic dysfunction in other retinal injuries. We explored the potential for nicotinamide to protect mitochondria in LHON by modelling the disease in mice through intravitreal injection of the Complex I inhibitor rotenone.
Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients
Conclusions: Nicotinamide (NAM) can prevent retinal vascular damage in an animal model of glaucoma. After NAM treatment, glaucoma patients and healthy controls demonstrated a small increase in retinal vessel parameters as assessed by OCTA.
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
These findings demonstrate that the inner retina and optic nerve head is highly enriched with the machinery to directly utilize nicotinamide through the salvage pathway and that the ability to do so is maintained, but the capacity to do so may be lower in glaucoma.
125 000 SEK to James Tribble from Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för synskadade.
James Tribble, Assistant Professor, Research group Williams got awarded 125 000 SEK from Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för synskadade.
This grant contributes to the Tribble lab’s ongoing research into neuroinflammation in glaucoma with a particular focus on the role of Galectin-3. - This project will identify how targeting Galectin-3 may influence the inflammatory profile of the cells of the retina, and how targeting it may provide neuroprotection in glaucoma.
Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system’s limited regenerative capacity. RGC repopulation is a promising therapeutic approach to reverse vision loss from optic neuropathies if the newly introduced neurons can reestablish functional retinal and thalamic circuits.