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Sten Eirik W. Jacobsen Lab (Hematopoietic Stem Cell Biology Group)

Unraveling normal and malignant hematopoietic stem and progenitor cell biology at the single cell level

Establishing the normal lineage commitment pathways from hematopoietic stem cells to lineage-restricted progenitors remains an important goal towards unravelling the regulation of blood lineage development, and how this is perturbed in hematological malignancies.

The Jacobsen Lab has for more than a decade had a focus on establishing key lineage commitment/restriction steps and blood lineage pathways in normal hematopoiesis (Adolfsson Cell 2005; Boiers Cell Stem Cell 2013; Sanjuan-Pla Nature 2013; Luis Nature Immunology 2016; Drissen Nature Immunology 2016; Carrelha Nature 2018). Distinct cancer stem cells (CSCs) might underlie relapses after complete remissions. The Jacobsen Lab has identified and characterized distinct and rare candidate CSCs and their therapeutic resistance in the chronic hematological malignancies myelodysplastic syndromes (MDS; Tehranchi New Engl J Med 2010; Woll Cancer Cell 2014) and myeloproliferative neoplasms (Mead N Engl J Med 2012; Giustacchini Nature Medicine 2017).

The current focus of the research program of the Jacobsen lab is to apply different genetic tools and functional as well as molecular single cell analysis to unravel the dynamics of stem and progenitor cells in unperturbed hematopoiesis as well as in response to distinct challenges, in mice as well as in normal human subjects. We also model the impact of recurrent genetic lesions at distinct stages of hematopoietic lineage commitment, to identify key cellular targets and molecular events in the transformation from normal to malignant hematopoiesis. In parallel we track the cellular fate and genetic evolution of clonal hematopoiesis in normal individuals as well as pre-leukemic and leukemic stem cells in patients during the natural course of hematopoietic malignancies and following treatment. Through these research directions we aim to identify novel therapeutic strategies towards regenerative hematopoiesis and targeting of leukemic stem cells.

The Jacobsen Group’s research program is in part pursued in his laboratory at the Karolinska Institute, Sweden at the Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge and at Haematopoietic Stem Cell Biology Laboratory, MRC Molecular HaematolgyUnit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine University of Oxford, Oxford, UK.

Group Members

Sten Eirik W. Jacobsen M.D., Ph.D., Professor, Group Leader
Dimitra Vasileiadi M.Sc., Research Administrator/ Personal Assistant to Prof. Jacobsen
Helena Venuti Hansén Substitute to Dimitra Vasileiadi
Ellen Markljung Ph.D., Senior Lab Manager
Kari Högstrand Ph.D., Senior Lab Manager
Amy Hillen M.Sc., Research Technician
Marios Dimitriou Post doc
Stefania Mazzi Post doc
Masafumi Seki M.D., Post doc
Tetsuichi Yoshizato M.D., Post doc
Karin Belander-Strålin M.D., PhD student

Selected publications

29298288

29438697

28504724

27695000

27043410

26780297

24835589

24054998

23934107

22397670

22344248

20825315

15851035

Link to all publications (PubMed)