Hedgehog Signalling - role of RNA-based mechanisms - Peter Zaphiropoulos
Our research interests are currently focused at providing a better molecular understanding of the role of Hedgehog signaling in cancer development - Peter Zaphiropoulos
This pathway, originally identified in Drosophila, is one of the major developmental cascades, and its deregulation may result cancerous transformation, with the first example being the most common form of skin cancer, basal cell carcinoma. We are now addressing regulatory mechanisms of Hedgehog signaling that implicate microRNA molecules, mRNA variants of signaling components, RNA editing, antisense transcription as well as epigenetic events. For clinical models of Hedgehog signal transduction, the childhood cancers of medulloblastoma, rhabdomyosarcoma and neuroblastoma, are mostly investigated. However, efforts to translate findings into additional tumours, including breast cancer, are also pursued, with the ultimate goal being the development of future therapeutic interventions.
Rune Toftgård's group