Liv Eidsmo

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i dermatologi och venereologi vid institutionen för medicin, Solna vid Karolinska Institutet samt överläkare vid Karolinska Universitetssjukhuset.

Forskningsbeskrivning

Människans hud bildar en barriär mot den yttre miljön som ständigt utsätts för koloniserande mikrobiota, invasiva patogener och allergener. Hudbarriären upprätthålls av immunceller, men dessa celler är också inblandade i vanliga inflammatoriska sjukdomar. I frisk hud har vi definierat funktionellt distinkta undergrupper av vävnadsresistenta minnes-T (Trm) celler baserat på deras uttryck av integrinet CD49a och vi har karakteriserat patogena Trm-celler i vitiligo och psoriasis.
Aktuella studier i mitt laboratorium syftar till att förstå hur mänskliga Trm-celler bildas och hur dessa celler påverkar sin omedelbara miljö.

Artiklar

Article: IMMUNITY. 2023;56(8):1955-1974.e10

Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.

Zwijnenburg AJ; Pokharel J; Varnaitė R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrström M; Gredmark-Russ S; Eidsmo L; Gerlach C
Article: IMMUNITY. 2023;56(6):1285-1302.e7

Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a.

Zitti B; Hoffer E; Zheng W; Pandey RV; Schlums H; Perinetti Casoni G; Fusi I; Nguyen L; Kärner J; Kokkinou E; Carrasco A; Gahm J; Ehrström M; Happaniemi S; Keita ÅV; Hedin CRH; Mjösberg J; Eidsmo L; Bryceson YT
Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2023;37(5):1004-1016

Secukinumab demonstrates superiority over narrow-band ultraviolet B phototherapy in new-onset moderate to severe plaque psoriasis patients: Week 52 results from the STEPIn study.

Iversen L; Conrad C; Eidsmo L; Costanzo A; Narbutt J; Pinter A; Kingo K; Rivera Diaz R; Kolbinger F; Nanna M; Frueh JA; Jagiello P
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 Pt A):705-716

Single-Cell Analysis Reveals Major Histocompatibility Complex II‒Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes.

Li D; Cheng S; Pei Y; Sommar P; Kärner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Xu Landén N
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(2):333-342.e6

IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation.

Padhi A; Srivastava A; Ramesh A; Ehrström M; Simon M; Sonkoly E; Eidsmo L; Bergman P; Lysell J
Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267

Intestinal helminth infection transforms the CD4+ T cell composition of the skin.

Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylén S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118

A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.

Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: ADVANCED MATERIALS TECHNOLOGIES. 2021;6(7):2001307

Vancomycin-Loaded Microneedle Arrays against Methicillin-Resistant Staphylococcus Aureus Skin Infections.

Ziesmer J; Tajpara P; Hempel N-J; Ehrström M; Melican K; Eidsmo L; Sotiriou GA
Article: JAMA DERMATOLOGY. 2021;157(6):684-690

Long-term Outcomes and Prognosis in New-Onset Psoriasis.

Svedbom A; Mallbris L; Larsson P; Nikamo P; Wolk K; Kjellman P; Sonkoly E; Eidsmo L; Lindqvist U; Ståhle M
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):13

Skin T cells maintain their diversity and functionality in the elderly.

Koguchi-Yoshioka H; Hoffer E; Cheuk S; Matsumura Y; Vo S; Kjellman P; Grema L; Ishitsuka Y; Nakamura Y; Okiyama N; Fujisawa Y; Fujimoto M; Eidsmo L; Clark RA; Watanabe R
Article: CELL REPORTS. 2019;29(5):1074-1081.e5

Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization.

Schulz A; Jiang L; de Vor L; Ehrström M; Wermeling F; Eidsmo L; Melican K
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(4):1444-1454

A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis.

Gallais Sérézal I; Hoffer E; Ignatov B; Martini E; Zitti B; Ehrström M; Eidsmo L
Article: PARASITE IMMUNOLOGY. 2019;41(4):e12618

Intestinal nematode infection exacerbates experimental visceral leishmaniasis.

Classon C; Feng X; Eidsmo L; Nylén S
Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2018;32(11):1930-1939

Secukinumab treatment in new-onset psoriasis: aiming to understand the potential for disease modification - rationale and design of the randomized, multicenter STEPIn study.

Iversen L; Eidsmo L; Austad J; de Rie M; Osmancevic A; Skov L; Talme T; Bachmann I; van de Kerkhof P; Stahle M; Banerjee R; Oliver J; Fasth AER; Frueh J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(8):1754-1763

Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome.

Gallais Sérézal I; Classon C; Cheuk S; Barrientos-Somarribas M; Wadman E; Martini E; Chang D; Xu Landén N; Ehrström M; Nylén S; Eidsmo L
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465

Human Immunodeficiency Virus-Infected Women Have High Numbers of CD103-CD8+ T Cells Residing Close to the Basal Membrane of the Ectocervical Epithelium.

Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Ball TB; Kimani J; Kaul R; Karlsson AC; Wählby C; Broliden K; Tjernlund A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638

MicroRNA-132 with Therapeutic Potential in Chronic Wounds.

Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grünler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrström M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Ståhle M; Xu Landén N
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(4):865-873

Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis.

Martini E; Wikén M; Cheuk S; Gallais Sérézal I; Baharom F; Ståhle M; Smed-Sörensen A; Eidsmo L
Article: SCIENTIFIC REPORTS. 2017;7:43989

Immunogenicity is preferentially induced in sparse dendritic cell cultures.

Nasi A; Bollampalli VP; Sun M; Chen Y; Amu S; Nylén S; Eidsmo L; Rothfuchs AG; Réthi B
Article: IMMUNITY. 2017;46(2):287-300

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin.

Cheuk S; Schlums H; Gallais Sérézal I; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Höög C; Tjernlund A; Michaëlsson J; Folkersen L; Mjösberg J; Blomqvist L; Ehrström M; Ståhle M; Bryceson YT; Eidsmo L
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075

Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.

Marquardt N; Ivarsson MA; Sundström E; Åkesson E; Martini E; Eidsmo L; Mjösberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger Å; Westgren M; Michaëlsson J
Article: NATURE COMMUNICATIONS. 2016;7:12175

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Liedén A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylén S; Westerberg LS
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(9):2351-2360

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.

Teunissen MBM; Munneke JM; Bernink JH; Spuls PI; Res PCM; Te Velde A; Cheuk S; Brouwer MWD; Menting SP; Eidsmo L; Spits H; Hazenberg MD; Mjösberg J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(6):1535-1541

Genetic variants of the IL22 promoter associate to onset of psoriasis before puberty and increased IL-22 production in T cells.

Nikamo P; Cheuk S; Lysell J; Enerbäck C; Bergh K; Xu Landén N; Eidsmo L; Ståhle M
Article: JOURNAL OF IMMUNOLOGY. 2014;192(7):3111-3120

Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis.

Cheuk S; Wikén M; Blomqvist L; Nylén S; Talme T; Ståhle M; Eidsmo L
Article: JOURNAL OF PATHOLOGY. 2012;226(5):806-813

Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.

Eidsmo L; Stock AT; Heath WR; Bedoui S; Carbone FR
Article: PARASITOLOGY. 2011;138(14):1898-1909

The interplay between Leishmania promastigotes and human Natural Killer cells in vitro leads to direct lysis of Leishmania by NK cells and modulation of NK cell activity by Leishmania promastigotes.

Lieke T; Nylén S; Eidsmo L; Schmetz C; Berg L; Akuffo H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529

MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.

Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Ståhle M; Sonkoly E; Pivarcsi A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2010;4(10):e844

Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration.

Tasew G; Nylén S; Lieke T; Lemu B; Meless H; Ruffin N; Wolday D; Asseffa A; Yagita H; Britton S; Akuffo H; Chiodi F; Eidsmo L
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Ståhle M; Pivarcsi A
Article: GLOBAL HEALTH ACTION. 2009;2:2046

Low-cost liquid medium for in vitro cultivation of Leishmania parasites in low-income countries.

Tasew G; Kebede A; Wolday D; Gadisa E; Britton S; Eidsmo L; Akuffo H
Article: JOURNAL OF IMMUNOLOGY. 2009;182(12):7587-7594

The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.

Lahoud MH; Proietto AI; Ahmet F; Kitsoulis S; Eidsmo L; Wu L; Sathe P; Pietersz S; Chang H-W; Walker ID; Maraskovsky E; Braley H; Lew AM; Wright MD; Heath WR; Shortman K; Caminschi I
Article: NATURE IMMUNOLOGY. 2009;10(5):488-495

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.

Bedoui S; Whitney PG; Waithman J; Eidsmo L; Wakim L; Caminschi I; Allan RS; Wojtasiak M; Shortman K; Carbone FR; Brooks AG; Heath WR
Article: NATURE IMMUNOLOGY. 2009;10(5):524-530

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.

Gebhardt T; Wakim LM; Eidsmo L; Reading PC; Heath WR; Carbone FR
Article: JOURNAL OF IMMUNOLOGY. 2009;182(5):3165-3172

Differential migration of epidermal and dermal dendritic cells during skin infection.

Eidsmo L; Allan R; Caminschi I; van Rooijen N; Heath WR; Carbone FR
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;153(2):221-230

Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation.

Lieke T; Nylén S; Eidsmo L; McMaster WR; Mohammadi AM; Khamesipour A; Berg L; Akuffo H
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(4):805-817

Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis.

Nylén S; Maurya R; Eidsmo L; Manandhar KD; Sundar S; Sacks D
Article: JOURNAL OF IMMUNOLOGY. 2007;178(8):5340-5350

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.

Fluur C; De Milito A; Fry TJ; Vivar N; Eidsmo L; Atlas A; Federici C; Matarrese P; Logozzi M; Rajnavölgyi E; Mackall CL; Fais S; Chiodi F; Rethi B
Article: AMERICAN JOURNAL OF PATHOLOGY. 2007;170(1):227-239

FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major.

Eidsmo L; Fluur C; Rethi B; Eriksson Ygberg S; Ruffin N; De Milito A; Akuffo H; Chiodi F
Article: VACCINE. 2006;24(47-48):6944-6954

Surrogate markers of immunity to Leishmania major in leishmanin skin test negative individuals from an endemic area re-visited.

Nylén S; Khamesipour A; Mohammadi A; Jafari-Shakib R; Eidsmo L; Noazin S; Modabber F; Akuffo H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2005;166(4):1099-1108

The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania major-induced cutaneous Leishmaniasis.

Eidsmo L; Nylen S; Khamesipour A; Hedblad M-A; Chiodi F; Akuffo H
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2002;130(2):307-313

Alteration of Fas and Fas ligand expression during human visceral leishmaniasis.

Eidsmo L; Wolday D; Berhe N; Sabri F; Satti I; El Hassan AM; Sundar S; Chiodi F; Akuffo H
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;117(3):529-534

Natural killer cells in cross-regulation of IL-12 by IL-10 in Leishmania antigen-stimulated blood donor cells.

Akuffo H; Alexis A; Eidsmo L; Saed A; Nylén S; Maasho K
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1995;52(2):181-186

Steroid 21-hydroxylase in the kidney: demonstration of levels of messenger RNA which correlate with the level of activity.

Lajic S; Eidsmo L; Holst M
Visa fler

Alla övriga publikationer

Letter: ALLERGY. 2022;77(12):3680-3683

T cells in resolved allergic contact dermatitis steer tissue inflammation and MMP-12-driven tissue modulation.

Gallais Sérézal I; Tajpara P; Schonfeldt T; Ignatov B; Sortebech D; Hoffer E; Zhang T; Rooijackers E; Ehrström M; Nylén S; Matura M; Melican K; Eidsmo L
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(16):1515-1516

New Hope for Patients with Vitiligo.

Eidsmo L
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(5):e12953

Cellular scars and local crosstalk in relapsing psoriasis: an example of a skin sticking disease.

Gallais Sérézal I; Cheuk S; Martini E; Eidsmo L
Editorial comment: TRENDS IN IMMUNOLOGY. 2018;39(3):170-172

Heavy Water Shedding Light on Antigen-Specific T Cell Responses.

Eidsmo L; Gerlach C
Review: FRONTIERS IN IMMUNOLOGY. 2018;9:300

Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions.

Eidsmo L; Martini E
Editorial comment: IMMUNITY. 2017;47(6):1012-1014

The Skinny on Fat Trm Cells.

Cheuk S; Eidsmo L
Letter: EXPERIMENTAL DERMATOLOGY. 2017;26(9):824-827

Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes.

Cheuk S; Martini E; Bergh K; Chang D; Rethi B; Ståhle M; Eidsmo L
Letter: EXPERIMENTAL DERMATOLOGY. 2017;26(5):444-446

IL-22 binding protein regulates murine skin inflammation.

Lindahl H; Martini E; Brauner S; Nikamo P; Gallais Serezal I; Guerreiro-Cacais AO; Jagodic M; Eidsmo L; Ståhle M; Olsson T
Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(8):1033-1043

Update on innate lymphoid cells in atopic and non-atopic inflammation in the airways and skin.

Mjösberg J; Eidsmo L
Review: PARASITE IMMUNOLOGY. 2012;34(12):551-561

Tissue damage and immunity in cutaneous leishmaniasis.

Nylén S; Eidsmo L
Review: FRONTIERS IN IMMUNOLOGY. 2012;3:163

FasL and TRAIL signaling in the skin during cutaneous leishmaniasis - implications for tissue immunopathology and infectious control.

Rethi B; Eidsmo L

Anställningar

Professor/Överläkare, Medicin, Solna, Karolinska Institutet, 2024-

Examina och utbildning

Docent, Dermatologi och venereologi, Karolinska Institutet, 2014
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2006
Läkarexamen, Karolinska Institutet, 1999

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

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