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Per Tornvall

Prefekt

Besöksadress : Sjukhusbacken 10 118 83 Stockholm
Postadress : Institutionen för klinisk forskning och utbildning, Södersjukhuset (KI SÖS), S1, Institutionen för klinisk forskning och utbildning, Södersjukhuset (KI SÖS), S1, Sjukhusbacken 10 118 83 Stockholm
Leveransadress : Sjukhusbacken 10 118 83 Stockholm

Om mig

Jag är i grunden hjärtläkare med kranskärlssjukdom som focus. Jag har tidigare arbetat på Karolinska sjukhuset i Solna i cirka 25 år. Under dessa år har jag bland annat varit överläkare på hjärtintensivvårdsavdelningen samt arbetat med perkutana koronara interventioner. Parallellt med det kliniska arbetet har jag forskat kring kranskärlssjukdom och undervisat såväl inom grundutbildning som fortbildning för hjärtläkare. Sedan 2012  är jag anställd av Karolinska Institutet som universitetslektor. Sedan två år tillbaka kombinerar jag mitt arbete som hjärtläkare med forskning och utbildning på Institutionen för klinisk forskning och utbildning på Södersjukhuset. De närmaste tre åren har jag även uppdraget att leda institutionen som prefekt. 

Forskningsbeskrivning

Brustet hjärta

Tack vare forskning kring åderförfettning, kranskärlsröntgen och känsliga metoder för att mäta hjärtmuskelskada är kunskapen om hjärtinfarkt stor idag. Kunskapen är dock begränsad till de patienter som har förträngningar i kranskärlen. Det har visat sig att upp till 10 % av alla hjärtinfarkter har normala kranskärl och upp till en tredjedel av alla kvinnor har hjärtinfarkt med normala kranskärl. Denna ganska nyupptäckta patientgrupp har inget bra svenskt namn men benämns ibland MINCA (myocardial infarction with normal coronary arteries). En stor del av denna grupp består av det som på svenska kallas brustet hjärta eller i den medicinska litteraturen Takotsubo vilket är ett tillstånd med nedsatt hjärtfunktion som sannolikt beror på stress.

Per Tornvalls forskargrupp har sedan 2007 bedrivit forskning kring denna patientgrupp. I en stor studie där alla Stockholmssjukhus deltagit (SMINC-studien) har de kunnat visa värdet av att utreda dessa patienter med MR för att bättre förstå och behandla detta nya tillstånd. De håller nu på att förbätte diagnostiken samt kartlägga dessa patienters kranskärl, livskvalitet, stressbenägenhet mm. En viktig del är nu att förbättra diagnostiken med ny känslig MR-teknik. Forskargruppen består såväl av läkare från Södersjukhuset som läkare från andra Stockholmssjukhus. SMINC-projektet har för närvarande 5 doktorander och har stöd från bland annat ALF och Vetenskapsrådet.

Publikationer

Effect of Myocardial Infarction With Nonobstructive Coronary Arteries on Physical Capacity and Quality-of-Life
Daniel M, Agewall S, Caidahl K, Collste O, Ekenbäck C, Frick M, et al
The American journal of cardiology 2017;120(3):341-346

Epidemiology, pathogenesis, and management of takotsubo syndrome
Y-hassan S, Tornvall P
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2017;():-

ESC working group position paper on myocardial infarction with non-obstructive coronary arteries
Agewall S, Beltrame Jf, Reynolds Hr, Niessner A, Rosano G, Caforio Al, et al
European heart journal 2017;38(3):143-153

Plasma biomarker levels and non-obstructive coronary artery disease determined by coronary computed tomography angiography
Brolin Eb, Agewall S, Cederlund K, Ekenbäck C, Henareh L, Malmqvist K, et al
Clinical physiology and functional imaging 2017;():-

Reply to comment by Elbadawi et al
Verouhis D, Sörensson P, Gourine A, Henareh L, Persson J, Saleh N, et al
American heart journal 2017;187():e7-e8

Reply to letter to the editor by Lou et al
Verouhis D, Sörensson P, Gourine A, Henareh L, Persson J, Saleh N, et al
American heart journal 2017;185():e2-

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample
Saha R, Kuja-halkola R, Tornvall P, Marions L
Journal of women's health (2002) 2017;26(2):152-158

The value of a new cardiac magnetic resonance imaging protocol in Myocardial Infarction with Non-obstructive Coronary Arteries (MINOCA) - a case-control study using historical controls from a previous study with similar inclusion criteria
Tornvall P, Brolin Eb, Caidahl K, Cederlund K, Collste O, Daniel M, et al
BMC cardiovascular disorders 2017;17(1):199-

Ticagrelor pharmacokinetics and pharmacodynamics in patients with NSTEMI after a 180-mg loading dose
Holm M, Tornvall P, Westerberg J, Rihan Hye S, Van Der Linden J
Platelets 2017;28(7):706-711

Validity of self-reported endometriosis and endometriosis-related questions in a Swedish female twin cohort
Saha R, Marions L, Tornvall P
Fertility and sterility 2017;107(1):174-178.e2

A Case-Control Study of Risk Markers and Mortality in Takotsubo Stress Cardiomyopathy
Tornvall P, Collste O, Ehrenborg E, Järnbert-petterson H
Journal of the American College of Cardiology 2016;67(16):1931-6

Does Coronary Angiography and Percutaneous Coronary Intervention Affect Cognitive Function?
Jurga J, Tornvall P, Dey L, Van Der Linden J, Sarkar N, Von Euler M
The American journal of cardiology 2016;118(10):1437-1441

Effect of remote ischemic conditioning on infarct size in patients with anterior ST-elevation myocardial infarction
Verouhis D, Sorensson P, Gourine A, Henareh L, Persson J, Saleh N, et al
AMERICAN HEART JOURNAL 2016;:66-73

GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information
Edsgärd D, Iglesias Mj, Reilly Sj, Hamsten A, Tornvall P, Odeberg J, et al
Scientific reports 2016;6():21134-

Hjartinfarkt utan kranskarlsfortrangningar ar vanligt - Viktigt identifiera differentialdiagnoser och mekanismer - behandlingen ar helt beroende pa orsak.
Tornvall P
Lakartidningen 2016;113():-

Kinematic analysis of diastolic function using the freely available software Echo E-waves - feasibility and reproducibility
Sundqvist Mg, Salman K, Tornvall P, Ugander M
BMC medical imaging 2016;16(1):60-

Outcome after percutaneous coronary intervention for different indications: long-term results from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
Fokkema Ml, James Sk, Albertsson P, Aasa M, Åkerblom A, Calais F, et al
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2016;12(3):303-11

[Percutaneous aortic valve implantation requires access to thoracic surgery]
Tornvall P, Rexius H, Vasko P
Lakartidningen 2016;113():-

Virtual reality training in coronary angiography and its transfer effect to real-life catheterisation lab
Jensen Uj, Jensen J, Ahlberg G, Tornvall P
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2016;11(13):1503-10

Virtual reality training in coronary angiography and its transfer effect to real-life catheterisation lab
Jensen Uj, Jensen J, Ahlberg G, Tornvall P
EUROINTERVENTION 2016;11(13):1549-53

Acute Systemic Inflammation is Unlikely to Affect Adiponectin and Leptin Synthesis in Humans
Ekström M, Söderberg S, Tornvall P
Frontiers in cardiovascular medicine 2015;2():7-

Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction
Mcleod O, Dunér P, Samnegård A, Tornvall P, Nilsson J, Hamsten A, et al
International journal of cardiology. Heart & vasculature 2015;6():42-47

Coronary flow reserve during dobutamine stress in Takotsubo stress cardiomyopathy
Collste O, Tornvall P, Alam M, Frick M
BMJ open 2015;5(7):e007671-

Heritability of endometriosis
Saha R, Pettersson Hj, Svedberg P, Olovsson M, Bergqvist A, Marions L, et al
Fertility and sterility 2015;104(4):947-952

Myocarditis or "true" infarction by cardiac magnetic resonance in patients with a clinical diagnosis of myocardial infarction without obstructive coronary disease: A meta-analysis of individual patient data
Tornvall P, Gerbaud E, Behaghel A, Chopard R, Collste O, Laraudogoitia E, et al
Atherosclerosis 2015;241(1):87-91

Neither endothelial function nor carotid artery intima-media thickness predicts coronary computed tomography angiography plaque burden in clinically healthy subjects: a cross-sectional study
Brolin Eb, Agewall S, Brismar Tb, Caidahl K, Tornvall P, Cederlund K
BMC cardiovascular disorders 2015;15():63-

NT-proBNP predicts maintenance of sinus rhythm after electrical cardioversion
Andersson J, Rosenqvist M, Tornvall P, Boman K
Thrombosis research 2015;135(2):289-91

Prevalence of Myocardial Bridging in Patients With Myocardial Infarction and Nonobstructed Coronary Arteries
Brolin Eb, Brismar Tb, Collste O, Y-hassan S, Henareh L, Tornvall P, et al
The American journal of cardiology 2015;116(12):1833-9

Reply:
Collste O, Tornvall P, Frick M
Journal of cardiac failure 2015;21(1):90-

Risk Factors and Markers for Acute Myocardial Infarction With Angiographically Normal Coronary Arteries
Daniel M, Ekenbäck C, Agewall S, Brolin Eb, Caidahl K, Cederlund K, et al
The American journal of cardiology 2015;116(6):838-44

[Spontaneous coronary artery dissection can cause acute coronary syndrome. Unusual condition that requires thoughtful management and more research]
Johnston N, Sarno G, Larsson B, Tornvall P, Varenhorst C
Lakartidningen 2015;112():-

Coronary plaque burden, as determined by cardiac computed tomography, in patients with myocardial infarction and angiographically normal coronary arteries compared to healthy volunteers: a prospective multicenter observational study
Brolin Eb, Jernberg T, Brismar Tb, Daniel M, Henareh L, Ripsweden J, et al
PloS one 2014;9(6):e99783-

Correlation between point-of-care platelet function testing and bleeding after coronary angiography according to two different definitions for bleeding
Holm M, Tornvall P, Dalén M, Van Der Linden J
The American journal of cardiology 2014;114(9):1347-53

Guidewire withdrawal in ascending aorta increases cerebral microembolism during coronary angiography: a randomized comparison of two guidewire techniques
Jurga J, Tornvall P, Van Der Linden J, Sarkar N
The Journal of invasive cardiology 2014;26(1):1-6

Is There an Effect of Contrast Media on Multifrequency Transcranial Doppler Classification of Cerebral Microemboli During Coronary Angiogram? Reply
Jurga J, Tornvall P, Van Der Linden J, Sarkar N
JOURNAL OF INVASIVE CARDIOLOGY 2014;26(10):E145-

No myocardial vulnerability to mental stress in Takotsubo stress cardiomyopathy
Collste O, Tornvall P, Sundin Ö, Alam M, Frick M
PloS one 2014;9(4):e93697-

Point-of-care testing of clopidogrel-mediated platelet inhibition and risk for cardiovascular events after coronary angiography with or without percutaneous coronary intervention
Holm M, Dalén M, Tornvall P, Van Der Linden J
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2014;25(6):577-84

The role of a simulator-based course in coronary angiography on performance in real life cath lab
Jensen Uj, Jensen J, Olivecrona G, Ahlberg G, Lagerquist B, Tornvall P
BMC medical education 2014;14():49-

Vulnerability to sympathetic stress does not persist in takotsubo stress cardiomyopathy
Collste O, Alam M, Sundqvist M, Olson J, Wardell J, Tornvall P, et al
Journal of cardiac failure 2014;20(12):968-72

Capecitabine caused cardiogenic shock through induction of global Takotsubo syndrome
Y-hassan S, Tornvall P, Törnerud M, Henareh L
Cardiovascular revascularization medicine : including molecular interventions 2013;14(1):57-61

Increased long-term expression of pentraxin 3 in irradiated human arteries and veins compared to internal controls from free tissue transfers
Christersdottir Björklund T, Reilly Sj, Gahm C, Bottazzi B, Mantovani A, Tornvall P, et al
Journal of translational medicine 2013;11():223-

Long-term impact of postconditioning on infarct size and left ventricular ejection fraction in patients with ST-elevation myocardial infarction
Sörensson P, Rydén L, Saleh N, Tornvall P, Arheden H, Pernow J
BMC cardiovascular disorders 2013;13():22-

Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study
Collste O, Sörensson P, Frick M, Agewall S, Daniel M, Henareh L, et al
Journal of internal medicine 2013;273(2):189-96

Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion
Tratsiakovich Y, Gonon At, Kiss A, Yang J, Böhm F, Tornvall P, et al
International journal of cardiology 2013;169(1):83-8

Technical skills assessment in a coronary angiography simulator for construct validation
Jensen Uj, Jensen J, Olivecrona Gk, Ahlberg G, Tornvall P
Simulation in healthcare : journal of the Society for Simulation in Healthcare 2013;8(5):324-8

The predictive value of C-reactive protein on recurrence of atrial fibrillation after cardioversion with or without treatment with atorvastatin
Höglund N, Andersson J, Almroth H, Tornvall P, Englund A, Rosenqvist M, et al
International journal of cardiology 2013;167(5):2088-91

Thyroid Dysfunction in Patients With Myocardial Infarction With Normal Coronary Arteries
Agewall S, Tornvall P
ANGIOLOGY 2013;64(3):245-6

Coronary artery bypass graft surgery up-regulates genes involved in platelet aggregation
Reilly Sj, Li N, Liska J, Ekstrom M, Tornvall P
JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2012;10(4):557-63

Identification and Predictive Value of Interleukin-6(+) Interleukin-10(+) and Interleukin-6(-) Interleukin-10(+) Cytokine Patterns in ST-Elevation Acute Myocardial Infarction
Ammirati E, Cannistraci Cv, Cristell Na, Vecchio V, Palini Ag, Tornvall P, et al
CIRCULATION RESEARCH 2012;111(10):1336-48

Risk Factors for Myocardial Infarction With Normal Coronary Arteries and Myocarditis Compared With Myocardial Infarction With Coronary Artery Stenosis
Agewall S, Daniel M, Eurenius L, Ekenback C, Skeppholm M, Malmqvist K, et al
ANGIOLOGY 2012;63(7):500-3

Serum 25-hydroxyvitamin D concentration, established and emerging cardiovascular risk factors and risk of myocardial infarction before the age of 60 years
Deleskog A, Piksasova O, Silveira A, Samnegard A, Tornvall P, Eriksson P, et al
ATHEROSCLEROSIS 2012;223(1):223-9

Stimulated in vivo synthesis of plasminogen activator inhibitor-1 in human adipose tissue
Ekström M, Liska J, Eriksson P, Sverremark-ekström E, Tornvall P
Thrombosis and haemostasis 2012;108(3):485-92

The use of fluoroscopy to construct learning curves for coronary angiography
Jensen Uj, Lagerquist B, Jensen J, Tornvall P
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2012;80(4):564-9

Beyond nuclear factor kappaB in cardiovascular disease induced by radiotherapy
Halle M, Tornvall P
JOURNAL OF INTERNAL MEDICINE 2011;270(5):486-

Cardiovascular disease associated with radiotherapy: activation of nuclear factor kappa-B
Halle M, Hall P, Tornvall P
JOURNAL OF INTERNAL MEDICINE 2011;269(5):469-77

Cerebral Microembolism During Coronary Angiography A Randomized Comparison Between Femoral and Radial Arterial Access
Jurga J, Nyman J, Tornvall P, Mannila Mn, Svenarud P, Van Der Linden J, et al
STROKE 2011;42(5):1475-7

CEREBRAL MICROEMBOLISM DURING CORONARY ANGIOGRAPHY: A RANDOMIZED COMPARISON BETWEEN TWO FLUSHING TECHNIQUES
Jurga J, Tornvall P, Van Der Linden J, Sarkar N
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2011;57(14):E1986-E1986

[Coronary disease is investigated and treated with advantage via catheter]
Saleh N, Ivert T, Tornvall P
Lakartidningen 2011;108(20):1108-12

Cytokine gene haplotypes with a potential effect on susceptibility to malaria in sympatric ethnic groups in Mali
Israelsson E, Maiga B, Kearsley S, Dolo A, Homann Mv, Doumbo Ok, et al
INFECTION GENETICS AND EVOLUTION 2011;11(7):1608-15

Genetic and Environmental Influences on the Plasma Interleukin-6 Concentration in Patients with a Recent Myocardial Infarction: A Case-Control Study
Bennermo M, Nordin M, Lundman P, Boqvist S, Held C, Samnegard A, et al
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 2011;31(2):259-64

Markers of fibrinolysis as predictors for maintenance of sinus rhythm after electrical cardioversion
Andersson J, Almroth H, Hoglund N, Jensen S, Tornvall P, Englund A, et al
THROMBOSIS RESEARCH 2011;127(3):189-92

Myocardial infarction with angiographically normal coronary arteries
Agewall S, Eurenius L, Hofman-bang C, Malmqvist K, Frick M, Jernberg T, et al
ATHEROSCLEROSIS 2011;219(1):10-4

[Percutaneous coronary interventions. Modern techniques improve quality of life]
Tornvall P
Lakartidningen 2011;108(20):1107-

[Takotsubo syndrome possible also in obstructive coronary vessel disease. The conditions do not exclude each other according to two case reports]
Y-hassan S, Sylvén C, Tornvall P
Lakartidningen 2011;108(15):864-7

Use of the Whole Leucocyte Population in the Study of the NF kappa B Pathway
Reilly Sj, Odeberg J, Tornvall P
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2011;73(4):338-43

Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography
Sorensson P, Heiberg E, Saleh N, Bouvier F, Caidahl K, Tornvall P, et al
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE 2010;:25-

Association of a Single Nucleotide Polymorphism in the C-reactive Protein Gene (-286) with Susceptibility to Plasmodium Falciparum Malaria
Elghazali G, Nasr A, Troye-bomberg M, Berzins K, Tornvall P, Giha H
CLINICAL IMMUNOLOGY 2010;:S117-S118

Association of a Single Nucleotide Polymorphism in the C-Reactive Protein Gene (-286) with Susceptibility to Plasmodium falciparum Malaria
Giha Ha, Nasr A, Ekstrom M, Israelsson E, Arambepola G, Arnot D, et al
MOLECULAR MEDICINE 2010;16(1-2):27-33

Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction
Sorensson P, Saleh N, Bouvier F, Bohm F, Settergren M, Caidahl K, et al
HEART 2010;96(21):1710-5

Endothelial activation with prothrombotic response in irradiated microvascular recipient veins
Halle M, Ekstrom M, Farnebo F, Tornvall P
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY 2010;63(11):1910-6

Sustained Inflammation Due to Nuclear Factor-Kappa B Activation in Irradiated Human Arteries
Halle M, Gabrielsen A, Paulsson-berne G, Gahm C, Agardh He, Farnebo F, et al
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2010;55(12):1227-36

Systemic inflammation activates the nuclear factor-kappa B regulatory pathway in adipose tissue
Ekstrom M, Halle M, Bjessmo S, Liska J, Kolak M, Fisher R, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2010;299(2):E234-40

Atorvastatin and persistent atrial fibrillation following cardioversion: a randomized placebo-controlled multicentre study
Almroth H, Hoglund N, Boman K, Englund A, Jensen S, Kjellman B, et al
EUROPEAN HEART JOURNAL 2009;30(7):827-33

Cardiac fatigue in long-distance runners is associated with ventricular repolarization abnormalities
Sahlen A, Rubulis A, Winter R, Jacobsen Ph, Stahlberg M, Tornvall P, et al
HEART RHYTHM 2009;6(4):512-9

Cerebral Embolism is Related to Access Site at Coronary Angiography
Jurga J, Nyman J, Sarkar N, Tornvall P, Mannila Mn, Svenarud P, et al
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2009;53(10):A23-A23

Coronary angiography of patients with a previous coronary artery by-pass operation is associated with a three times increased risk for neurological complications. A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
Nilsson T, Lagerqvist B, Tornvall P
SCANDINAVIAN CARDIOVASCULAR JOURNAL 2009;43(6):374-9

Effect of Postconditioning on Infarct Size in Patients With ST-elevation Myocardial Infarction
Sorensson P, Saleh N, Bouvier F, Bohm F, Settergren M, Caidahl K, et al
CIRCULATION 2009;120(18):S869-S869

Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa
Israelsson E, Ekstrom M, Nasr A, Dolo A, Kearsley S, Arambepola G, et al
MALARIA JOURNAL 2009;:136-

Relevance of genetic polymorphisms in inflammatory response to percutaneous coronary intervention
Saleh N, Kovacs A, Tornvall P
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 2009;69(7):736-40

Timing of radiotherapy in head and neck free flap reconstruction - a study of postoperative complications
Halle M, Bodin I, Tornvall P, Wickman M, Farnebo F, Arnander C
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY 2009;62(7):889-95

[Coronary radiography has held true for 50 years]
Tornvall P, Nilsson T
Lakartidningen 2008;105(43):3048-51

Large differences in rate of clinical restenosis between different stents - Long term follow-up from the Swedish angiography and angioplasty registry (SCAAR)
James Sk, Nilsson T, Carlsson J, Sjogren I, Tornvall P, Schersten F, et al
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2008;51(10):B89-B89

The inflammatory response to femoral arterial closure devices: A randomized comparison among FemoStop, AngioSeal, and Perclose
Jensen J, Saleh N, Jensen U, Svane B, Jonsson A, Tornvall P
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY 2008;31(4):751-5

Vaccination, a human model of inflammation, activates systemic inflammation but does not trigger proinflammatory gene expression in adipose tissue
Ekstrom M, Eriksson P, Tornvall P
JOURNAL OF INTERNAL MEDICINE 2008;264(6):613-7

A high-fat meat is accompanied by increased plasma interleukin-6 concentrations
Lundman P, Boquist S, Samnegard A, Bennermo M, Held C, Ericsson Cg, et al
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 2007;17(3):195-202

Climbing the cardiology career ladder: Sweden. Interview by Barry Shurlock
Tornvall P
Circulation 2007;116(2):f9-10

Coagulation factor VII and inflammatory markers in patients with coronary heart disease
Ekstrom M, Silveira A, Bennermo M, Eriksson P, Tornvall P
BLOOD COAGULATION & FIBRINOLYSIS 2007;18(5):473-7

Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease
Perneby C, Wallen Nh, Hofman-bang C, Tornvall P, Ivert T, Li Nl, et al
THROMBOSIS AND HAEMOSTASIS 2007;98(6):1316-22

Effects of revascularization within 14 days of hospital admission due to acute coronary syndrome on 1-year mortality in patients with previous coronary artery bypass graft surgery
Held C, Tornvall P, Stenestrand U
EUROPEAN HEART JOURNAL 2007;28(3):316-25

Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia
Kovacs A, Tornvall P, Nilsson R, Tegner J, Hamsten A, Bjorkegren J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(34):13768-73

Limited prognostic value of noninvasive assessment of reperfusion by continuous vectorcardiography in an unselected cohort of patients with acute ST-elevation myocardial infarction treated with thrombolysis
Eriksson M, Hofman-bang C, Persson H, Tornvall P
JOURNAL OF ELECTROCARDIOLOGY 2007;40(3):305-10

[Myocardial infarction with normal coronary arteries in women. MINCA--a specific type of myocardial infarction]
Skeppholm M, Agewall S, Ljungman P, Daniel M, Eriksson M, Hofman-bang C, et al
Lakartidningen 2007;104(37):2586-8

Serum C-reactive protein response to percutaneous coronary intervention in patients with unstable or stable angina pectoris is associated with the risk of clinical restenosis
Saleh N, Tornvall P
ATHEROSCLEROSIS 2007;195(2):374-8

Clinical and angiographic follow-up after coronary drug-eluting and bare metal stent implantation. Do drug-eluting stents hold the promise?
Jensen J, Lagerqvist B, Aasa M, Sarev T, Nilsson T, Tornvall P
JOURNAL OF INTERNAL MEDICINE 2006;260(2):118-24

Cytomegalovirus in coronary heart disease
Tornvall P, Saleh N, Zweygberg-wirgart B, Grillner L
ATHEROSCLEROSIS 2006;184(1):235-

Deadly myocardial fibrosis of unknown etiology in adolescence
Tornvall P, Lindholm J, Svjatoha V, Gonon A
CARDIOLOGY 2006;105(3):162-4

Effects of revascularization within 14 days of hospital admission due to acute coronary syndrome on 1-year mortality in patients with previous coronary artery by-pass graft surgery
Held C, Tornvall P, Stenestrand U
EUROPEAN HEART JOURNAL 2006;:182-182

Effects on mortality of abciximab in ST-elevation myocardial infarction treated with percutaneous coronary intervention including stent implantation
Tornvall P, Nilsson T, Lagerqvist B
JOURNAL OF INTERNAL MEDICINE 2006;260(4):363-8

Influence of eotaxin 67g > a polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls.
Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M
CLINICAL IMMUNOLOGY 2006;:S127-S128

Influence of eotaxin 67G > A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls
Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):280-280

Influence of eotaxin 67G > A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls
Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M
ATHEROSCLEROSIS 2006;189(2):458-63

Lower serum concentration of matrix metalloproteinase-3 in the acute stage of myocardial infarction
Samnegard A, Silveira A, Tornvall P, Hamsten A, Ericsson Cg, Eriksson P
JOURNAL OF INTERNAL MEDICINE 2006;259(5):530-6

Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related-to severity of coronary atherosclerosis independently of C-reactive protein and IL-6
Hulthe J, Mcpheat W, Samnegard A, Tornvall P, Hamsten A, Eriksson P
ATHEROSCLEROSIS 2006;188(2):450-4

Usefulness of preprocedural serum N-terminal pro-brain natriuretic peptide levels to predict long-term outcome after percutaneous coronary intervention in patients with normal troponin T levels
Saleh N, Braunschweig F, Jensen J, Tornvall P
AMERICAN JOURNAL OF CARDIOLOGY 2006;97(6):830-4

A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein
Kovacs A, Green F, Hansson Lo, Lundman P, Samnegard A, Boquist S, et al
ATHEROSCLEROSIS 2005;178(1):193-8

Contrast medium attenuates platelet activation and plateletleukocyte cross-talk
Ji Qs, Ghaly M, Hiemdahl P, Tornvall P, Li Nl
THROMBOSIS AND HAEMOSTASIS 2005;93(5):922-6

Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction
Mannila Mn, Eriksson P, Lundman P, Samnegard A, Boquist S, Ericsson Cg, et al
THROMBOSIS AND HAEMOSTASIS 2005;93(3):570-7

Effects of free fatty acids and a triglyceride-rich fat emulsion on endothelial nitric oxide synthase
Halle M, Eriksson P, Tornvall P
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2005;35(2):154-5

Genotype-specific increase in plasma concentrations of activated coagulation factor VII in response to experimental inflammation - A link between infection and acute myocardial infarction?
Bennermo M, Held C, Ericsson Cg, Silveira A, Hamsten A, Tornvall P
THROMBOSIS AND HAEMOSTASIS 2005;94(2):427-31

Genotype-specific increase in plasma concentrations of activated coagulation factor VII in response to experimental inflammation. A link between infection and acute myocardial infarction
Tornvall P, Held C, Ericsson Cg, Silveira A, Hamsten A, Bennermo M
ATHEROSCLEROSIS SUPPLEMENTS 2005;6(1):94-95

Hormonal regulation of circulating C-reactive protein in men
Kovacs A, Henriksson P, Hamsten A, Wallen H, Bjorkegren J, Tornvall P
CLINICAL CHEMISTRY 2005;51(5):911-3

[PCI is now a refined method for treatment of coronary stenoses]
Tornvall P, Nilsson T, Jensen J
Lakartidningen 2005;102(36):2478-81

Plasma C-reactive protein and lipoprotein levels, and progression of coronary artery disease after myocardial infarction treated with thrombolysis
Tornvall P, Hamsten A, Hansson Lo, O'konor Ml, Ericsson Cg, Strandberg Le, et al
CARDIOLOGY 2005;104(2):65-71

Response of serum C-reactive protein to percutaneous coronary intervention has prognostic value
Saleh N, Svane B, Hansson Lo, Jensen J, Nilsson T, Danielsson O, et al
CLINICAL CHEMISTRY 2005;51(11):2124-30

Serum matrix metalloproteinase-3 concentration is influenced by MMP-3-1612 5A/6A promoter genotype and associated with myocardial infarction
Samnegard A, Silveira A, Lundman P, Boquist S, Odeberg J, Hulthe J, et al
JOURNAL OF INTERNAL MEDICINE 2005;258(5):411-9

Severity of coronary artery stenosis is associated with a polymorphism in the CXCL16/SR-PSOX gene
Lundberg Ga, Kellin A, Samnegard A, Lundman P, Tornvall P, Dimmeler S, et al
JOURNAL OF INTERNAL MEDICINE 2005;257(5):415-22

Skin dose alarm levels in cardiac angiography procedures: is a single DAP value sufficient?
Karambatsakidou A, Tornvall P, Saleh N, Chouliaras T, Lofberg P, Fransson A
BRITISH JOURNAL OF RADIOLOGY 2005;78(933):803-9

Stent implantation, but not pathogen burden, is associated with plasma C-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris
Saleh N, Svane B, Jensen J, Hansson Lo, Nordin M, Tornvall P
AMERICAN HEART JOURNAL 2005;149(5):876-82

C-reactive protein and myocardial infarction during percutaneous coronary intervention
Saleh N, Svane B, Velander M, Nilsson T, Hansson Lo, Tornvall P
JOURNAL OF INTERNAL MEDICINE 2004;255(1):33-9

Does TNF-alpha blockade cause plaque rupture?
Settergren M, Tornvall P
ATHEROSCLEROSIS 2004;173(1):149-

[Drug-eluting stents in coronary arteries. The risk of restenosis is drastically reduced]
Tornvall P
Lakartidningen 2004;101(51-52):4175-

Effect of interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe
Hifmech Study Grp, Kelberman D, Hawe E, Luong La, Mohamed-ali V, Lundman P, et al
THROMBOSIS AND HAEMOSTASIS 2004;92(5):1122-8

Genetic predisposition of the interleukin-6 response to inflammation: Implications for a variety of major diseases?
Bennermo M, Held C, Stemme S, Ericsson Cg, Silveira A, Green F, et al
CLINICAL CHEMISTRY 2004;50(11):2136-40

Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease
Eriksson P, Deguchi H, Samnegard A, Lundman P, Boquist S, Tornvall P, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2004;24(3):551-7

Prognostic value of plasma interleukin-6 concentrations and the -174 G > C and -572 G > C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis
Bennermo M, Held C, Green F, Strandberg Le, Ericsson Cg, Hansson Lo, et al
ATHEROSCLEROSIS 2004;174(1):157-63

A case report supporting multiple plaque ruptures in CAD
Tornvall P, Jensen J, Persson H, Lundman P
CARDIOLOGY 2003;99(4):214-5

Autoantibodies against modified low-density lipoproteins in coronary artery disease
Tornvall P, Waeg G, Nilsson J, Hamsten A, Regnstrom J
ATHEROSCLEROSIS 2003;167(2):347-53

Comparison of effects of a thrombin-based femoral artery closure device with those of a mechanical compression device on serum C-reactive protein and amyloid A after percutaneous coronary intervention
Saleh N, Olausson A, Nilsson T, Hansson Lo, Tornvall P
AMERICAN JOURNAL OF CARDIOLOGY 2003;92(3):324-7

[C-reactive protein potential risk factor for cardiovascular disease]
Tornvall P, Pernow J, Hansson Lo
Lakartidningen 2003;100(35):2691-3

Genetic susceptibility to the interleukin-6 inflammatory response to vaccination
Bennermo M, Held C, Silveira A, Tornvall P
CIRCULATION 2003;108(17):104-104

Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease
Eriksson P, Deguchi H, Samnegard A, Lundman P, Boquist S, Tornvall P, et al
ATHEROSCLEROSIS SUPPLEMENTS 2003;4(2):323-323

In vitro and in vivo lipolysis of plasma triglycerides increases the resistance to oxidative modification of low-density lipoproteins
Skoglund-andersson C, Karpe F, Hellenius Ml, Regnstrom J, Hamsten A, Tornvall P
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2003;33(1):51-7

No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction
Lagercrantz J, Bergman M, Lundman P, Tornvall P, Hjemdahl P, Hamsten A, et al
BLOOD COAGULATION & FIBRINOLYSIS 2003;14(8):749-53

Prognostic value of plasma C-reactive protein and fibrinogen determinations in patients with acute myocardial infarction treated with thrombolysis
Bennermo M, Held C, Hamsten A, Strandberg Le, Ericsson Cg, Hansson Lo, et al
JOURNAL OF INTERNAL MEDICINE 2003;254(3):244-50

Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1)
Lundman P, Eriksson Mj, Silveira A, Hansson Lo, Pernow J, Ericsson Cg, et al
AMERICAN JOURNAL OF CARDIOLOGY 2003;91(9):1128-31

The plasminogen activator inhibitor-1-675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH Study
Hifmech Study Grp, Juhan-vague I, Morange Pe, Frere C, Aillaud Mf, Alessi Mc, et al
JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2003;1(11):2322-9

Under utilisation of evidence-based treatment partially explains for the unfavourable prognosis in diabetic patients with acute myocardial infarction
Register Information Knowledge Swe, Norhammar A, Malmberg K, Ryden L, Tornvall P, Stenestrand U, et al
EUROPEAN HEART JOURNAL 2003;24(9):838-44

Platelet function and myocardial injury during percutaneous coronary intervention
Saleh N, Hansson Lo, Kohut M, Nilsson T, Tornvall P
JOURNAL OF THROMBOSIS AND THROMBOLYSIS 2002;13(2):69-73

[Treatment of coronary artery stenosis. Considerable improvement of the catheter-based technique]
Tornvall P, Jensen J, Nilsson T
Lakartidningen 2002;99(25):2840-3

[A controlled trial with prolonged follow up: percutaneous intervention in acute myocardial infarction is equivalent to thrombolytic therapy]
Tornvall P, Johansson M, Herzfeld I, Nilsson T
Lakartidningen 2001;98(32-33):3397-9

A hypothesis to explain the reported association of the alpha-fibrinogen A312 allele with thromboembolic disease
Curran Jm, Fatah-ardalani K, Tornvall P, Humphries Se, Green Fr
THROMBOSIS AND HAEMOSTASIS 2001;85(6):1122-3

A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation
Lundman P, Tornvall P, Nilsson L, Pernow J
ATHEROSCLEROSIS 2001;159(1):35-41

Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine
Lundman P, Eriksson Mj, Stuhlinger M, Cooke Jp, Hamsten A, Tornvall P
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2001;38(1):111-6

Mild to moderate hypertriglyceridemia is associated with endothelial dysfunction and low-grade inflammation
Lundman Pim, Eriksson Mj, Stuehlinger M, Cooke Jp, Tornvall P
CIRCULATION 2001;104(17):240-240

Under-utilisation of evidence-based treatment a partial explanation to the unfavourable prognosis in diabetic patients with acute myocardial infarction
Norhammar A, Malmberg K, Ryden L, Tornvall P, Stenestrand U, Wallentin L
CIRCULATION 2001;104(17):626-626

Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease
Bjorkegren J, Boquist S, Samnegard A, Lundman P, Tornvall P, Ericsson Cg, et al
CIRCULATION 2000;101(3):227-30

Diabetes mellitus is a strong negative prognostic factor in patients with myocardial infarction treated with thrombolytic therapy
Strandberg Le, Ericsson Cg, O'konor Ml, Bergstrand L, Lundin P, Rehnqvist N, et al
JOURNAL OF INTERNAL MEDICINE 2000;248(2):119-25

A functional polymorphism in the apolipoprotein B promoter that influences the level of plasma low density lipoprotein
Van 't Hooft Fm, Jormsjo S, Lundahl B, Tornvall P, Eriksson P, Hamsten A
JOURNAL OF LIPID RESEARCH 1999;40(9):1686-94

Native and oxidized low density lipoproteins enhance platelet aggregation in whole blood
Tornvall P, Chirkova L, Toverud Kd, Horowitz Jd, Chirkov Y
THROMBOSIS RESEARCH 1999;95(4):177-83

Two common functional polymorphisms in the promoter region of the coagulation factor VII gene determining plasma factor VII activity and mass concentration
Van't Hooft Fm, Silveira A, Tornvall P, Iliadou A, Ehrenborg E, Eriksson P, et al
BLOOD 1999;93(10):3432-41

Coagulation factor V (Arg(506)-> Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting
Moor E, Silveira A, Van't Hooft F, Tornvall P, Blomback M, Wiman B, et al
THROMBOSIS AND HAEMOSTASIS 1998;80(2):220-4

Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease
Jovinge S, Hamsten A, Tornvall P, Proudler A, Bavenholm P, Ericsson Cg, et al
METABOLISM-CLINICAL AND EXPERIMENTAL 1998;47(1):113-8

Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of coronary artery disease
Regnstrom J, Jovinge S, Bavenholm P, Ericsson Cg, De Faire U, Hamsten A, et al
JOURNAL OF INTERNAL MEDICINE 1998;243(2):109-13

Ischaemia monitoring with on-line vectorcardiography during dobutamine stress echocardiography in patients after an episode of unstable coronary artery disease
Lundin P, Eriksson Sv, Andren B, Lindahl B, Tornvall P, Melcher A
JOURNAL OF INTERNAL MEDICINE 1998;244(1):61-70

Transient triglyceridemia in healthy normolipidemic men increases cellular processing of large very low density lipoproteins by fibroblasts in vitro
Bjorkegren J, Karpe F, Vitols S, Tornvall P, Hamsten A
JOURNAL OF LIPID RESEARCH 1998;39(2):423-36

Triglycerides and postprandial angina - Response
Lundman P, Tornvall P, Eriksson M, Schenck-gustafsson K, Karpe F
CIRCULATION 1998;98(17):1827-1827

Postprandial very low density lipoproteins: Composition and cellular interactions
Bjorkegren J, Karpe F, Tornvall P, Hamsten A
ATHEROSCLEROSIS 1997;134(1-2):337-337

Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease
Lundman P, Eriksson M, Schenckgustafsson K, Karpe F, Tornvall P
CIRCULATION 1997;96(10):3266-8

A decrease in cardiovascular risk factors in healthy 40-year-old Swedish men between 1980-1983 and 1991-1992
Tornvall P, Båvenholm P, Hellénius Ml, Karpe F, Regnström J, De Faire U
Journal of cardiovascular risk 1996;3(4):379-83

High-density lipoprotein: Relations to metabolic parameters and severity of coronary artery disease
Tornvall P, Karpe F, Proudler A, Bavenholm P, Landou C, Olivecrona T, et al
METABOLISM-CLINICAL AND EXPERIMENTAL 1996;45(11):1375-82

Inverse relation between the concentration of low-density lipoprotein Vitamin E and severity of coronary artery disease
Regnstrom J, Nilsson J, Moldeus P, Strom K, Bavenholm P, Tornvall P, et al
AMERICAN JOURNAL OF CLINICAL NUTRITION 1996;63(3):377-85

Proneness to formation of tight and rigid fibrin gel structures in men with myocardial infarction at a young age
Fatah K, Silveira A, Tornvall P, Karpe F, Blomback M, Hamsten A
THROMBOSIS AND HAEMOSTASIS 1996;76(4):535-40

ASSOCIATION OF INSULIN AND INSULIN PROPEPTIDES WITH AN ATHEROGENIC LIPOPROTEIN PHENOTYPE
Bavenholm P, Karpe F, Proudler A, Tornvall P, Crook D, Hamsten A
METABOLISM-CLINICAL AND EXPERIMENTAL 1995;44(11):1481-8

CELLULAR PROCESSING OF APOLIPOPROTEIN B-CONTAINING LIPOPROTEINS FROM YOUNG POSTINFARCTION PATIENTS AND HEALTHY CONTROLS
Tornvall P, Regnstrom J, Hamsten A
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 1995;25(9):699-707

INSULIN, INTACT AND SPLIT PROINSULIN, AND CORONARY-ARTERY DISEASE IN YOUNG MEN
Bavenholm P, Proudler A, Tornvall P, Godsland I, Landou C, Defaire U, et al
CIRCULATION 1995;92(6):1422-9

LIPOPROTEIN-LIPASE MASS AND ACTIVITY IN PLASMA AND THEIR INCREASE AFTER HEPARIN ARE SEPARATE PARAMETERS WITH DIFFERENT RELATIONS TO PLASMA-LIPOPROTEINS
Tornvall P, Olivecrona G, Karpe F, Hamsten A, Olivecrona T
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1995;15(8):1086-93

THE SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN TO CHEMICAL OXIDATION IS CLOSELY-RELATED TO PRONENESS TO BIOLOGICAL MODIFICATION
Frostegard J, Regnstrom J, Tornvall P, Hamsten A, Nilsson J
FREE RADICAL RESEARCH 1995;23(6):581-92

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