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Gustaf Edgren

Forskare

Om mig

Jag är för närvarande post doc vid Institutionen för medicinsk epidemiologi och biostatistik vid Karolinska Institutet. Jag försvarade min avhandling, "Blood donors' long term health: implications for transfusion safety" i december, 2007.

Sedan min disputation har min forskning framförallt fokuserat på långtidskomplikationer av blodtransfusioner och blodtappningar. Min avhandling belönades med Dmitris N Chorafas pris år 2008.

Inom ramen för avhandlingsarbetet var jag koordinator för den svenska delen av den svensk-danska SCANDAT-databasen (Scandinavian Donations and Transfusions), som innehåller data om blodtappningar och blodtransfusioner i Sverige och Danmark mellan 1968 och 2002.

Utbildning

  • Läkarexamen, Karolinska Institutet, 2010.
  • Medicine doktor, epidemiologi, Karolinska Institutet, 2007.
  • Med kand, Karolinska Institutet, 2004.

Forskningsbeskrivning

Mitt huvudsakliga forskningsfokus är etiologisk epidemiologi någonstans i gränslandet mellan cancerepidemiologi och transfusionsmedicin. Successivt har jag dessutom involverat mig mer i kliniskt tillämpad transfusionsmedicinsk forskning, och då särskilt i studier av de akuta hälsoeffekterna av blodtransfusioner. Nyligen har vi även erhållit ekonomiskt stöd för en studie av ARDS-/TRALI-klustring.

Utöver min transfusionsrelaterade forskning har jag även deltagit i studier om ärftlig bröstcancer samt implikationerna av förändringar i bröstdensitet för patienter med bröstcancer.

Akademiska priser och utmärkelser

  • Dmitris N Chorafas pris för avhandlingen "Blood donors' long term health: implications for transfusion safety" år 2008.

Länkar

Publikationer

ABO Blood Group and Risk of Thromboembolic and Arterial Disease: A Study of 1.5 Million Blood Donors
Vasan Sk, Rostgaard K, Majeed A, Ullum H, Titlestad Ke, Pedersen Ob, et al
Circulation 2016;133(15):1449-57

A case management intervention targeted to reduce healthcare consumption for frequent Emergency Department visitors: results from an adaptive randomized trial
Edgren G, Anderson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al
European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2016;23(5):344-50

Blood donation and risk of polycythemia vera
Edgren G, Nyrén O, Hultcrantz M, Nielsen Kr, Pedersen Ob, Björkholm M, et al
Transfusion 2016;56(6 Pt 2):1622-7

Cardiovascular Events Associated With Use of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Population-Based Cohort Study
Dahlén T, Edgren G, Lambe M, Höglund M, Björkholm M, Sandin F, et al
Annals of internal medicine 2016;165(3):161-6

Citrate anticoagulation: Are blood donors donating bone?
Bialkowski W, Bruhn R, Edgren G, Papanek P
Journal of clinical apheresis 2016;31(5):459-63

Epidemiology of Massive Transfusion: A Binational Study From Sweden and Denmark
Halmin M, Chiesa F, Vasan Sk, Wikman A, Norda R, Rostgaard K, et al
Critical care medicine 2016;44(3):468-77

Haemostasis monitored in stored red blood cells, plasma and platelet concentrates in the proportion of 4 :  4 :  1 diluted with crystalloids and colloids
Ågren A, Edgren G, Ambrosio D, Gryfelt G, Östlund A, Wikman A
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2016;27(3):334-9

Lack of association between blood donor age and survival of transfused patients
Vasan Sk, Chiesa F, Rostgaard K, Magnusson Pk, Halmin M, Nielsen Kr, et al
Blood 2016;127(5):658-61

[Not Available]
Edgren G, Andersson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al
Lakartidningen 2016;113():-

[Not Available]
Edgren G, Anderson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al
Lakartidningen 2016;113():-

Risk of basal cell carcinoma in Swedish organ transplant recipients: a population-based study
Krynitz B, Olsson H, Lundh Rozell B, Lindelöf B, Edgren G, Smedby Ke
The British journal of dermatology 2016;174(1):95-103

Transmission of Neurodegenerative Disorders Through Blood Transfusion: A Cohort Study
Edgren G, Hjalgrim H, Rostgaard K, Lambert P, Wikman A, Norda R, et al
Annals of internal medicine 2016;165(5):316-24

ABO Blood Group and Dementia Risk--A Scandinavian Record-Linkage Study
Vasan Sk, Rostgaard K, Ullum H, Melbye M, Hjalgrim H, Edgren G
PloS one 2015;10(6):e0129115-

Blood donation and blood donor mortality after adjustment for a healthy donor effect
Ullum H, Rostgaard K, Kamper-jørgensen M, Reilly M, Melbye M, Nyrén O, et al
Transfusion 2015;55(10):2479-85

No evidence of transmission of chronic lymphocytic leukemia through blood transfusion
Hjalgrim H, Rostgaard K, Vasan Sk, Ullum H, Erikstrup C, Pedersen Ob, et al
Blood 2015;126(17):2059-61

Red Blood Cell Concentrate Storage and Survival After Cardiac Surgery
Sartipy U, Holzmann Mj, Hjalgrim H, Edgren G
JAMA 2015;314(15):1641-3

The heritability of blood donation: a population-based nationwide twin study
Pedersen Ob, Axel S, Rostgaard K, Erikstrup C, Edgren G, Nielsen Kr, et al
Transfusion 2015;55(9):2169-74

The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility
Edgren G, Rostgaard K, Vasan Sk, Wikman A, Norda R, Pedersen Ob, et al
Transfusion 2015;55(7):1600-6

In response
Agren A, Wikman A, Ostlund A, Edgren G
Anesthesia and analgesia 2014;119(6):1453-

In vitro combinations of red blood cell, plasma and platelet components evaluated by thromboelastography
Agren A, Edgren G, Kardell M, Ostlund A, Wikman At
Blood transfusion = Trasfusione del sangue 2014;12(4):491-6

Pregnancy during breast cancer: does a mother's parity status modify an offspring's mortality risk?
Simonella L, Verkooijen Hm, Edgren G, Liu J, Hui M, Salim A, et al
Breast cancer research and treatment 2014;146(2):393-9

Splenectomy and the risk of sepsis: a population-based cohort study
Edgren G, Almqvist R, Hartman M, Utter Gh
Annals of surgery 2014;260(6):1081-7

TEG® functional fibrinogen analysis may overestimate fibrinogen levels
Agren A, Wikman At, Ostlund A, Edgren G
Anesthesia and analgesia 2014;118(5):933-5

The authors reply
Halmin Ma, Edgren G
Critical care medicine 2014;42(3):e245-6

A global assessment of the oesophageal adenocarcinoma epidemic
Edgren G, Adami Ho, Weiderpass E, Nyrén O
Gut 2013;62(10):1406-14

A global assessment of the oesophageal adenocarcinoma epidemic (vol 62, pg 1406, 2013)
Edgren G, Adami Ho, Weiderpass E
GUT 2013;62(12):1820-1820

A telephone-based case-management intervention reduces healthcare utilization for frequent emergency department visitors
Reinius P, Johansson M, Fjellner A, Werr J, Ohlén G, Edgren G
European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2013;20(5):327-34

Effect of plasma-to-RBC ratios in trauma patients: a cohort study with time-dependent data*
Halmin M, Boström F, Brattström O, Lundahl J, Wikman A, Östlund A, et al
Critical care medicine 2013;41(8):1905-14

Mammographic density reduction is a prognostic marker of response to adjuvant tamoxifen therapy in postmenopausal patients with breast cancer
Li J, Humphreys K, Eriksson L, Edgren G, Czene K, Hall P
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(18):2249-56

Overall and cause-specific mortality in transplant recipients with a pretransplantation cancer history
Brattström C, Granath F, Edgren G, Smedby Ke, Wilczek He
Transplantation 2013;96(3):297-305

Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008--a Swedish population-based study
Krynitz B, Edgren G, Lindelöf B, Baecklund E, Brattström C, Wilczek H, et al
International journal of cancer 2013;132(6):1429-38

Screening, case finding or primary cancer prevention in the developing world?
Edgren G, Lagiou P, Trichopoulos D, Adami Ho
European journal of epidemiology 2013;28(4):287-90

Thromboelastography (TEG®) compared to conventional coagulation tests in surgical patients--a laboratory evaluation
Ågren A, Wikman At, Holmström M, Östlund A, Edgren G
Scandinavian journal of clinical and laboratory investigation 2013;73(3):214-20

Enigmatic sex disparities in cancer incidence
Edgren G, Liang Lm, Adami Ho, Chang Et
EUROPEAN JOURNAL OF EPIDEMIOLOGY 2012;27(3):187-96

Epidemiology of adult ankle fractures in Sweden between 1987 and 2004 A population-based study of 91,410 Swedish inpatients
Thur Ck, Edgren G, Jansson Ka, Wretenberg P
ACTA ORTHOPAEDICA 2012;83(3):276-81

Temporal Trends in Cause of Death Among Swedish and US Men with Prostate Cancer
Epstein Mm, Edgren G, Rider Jr, Mucci La, Adami Ho
JOURNAL OF THE NATIONAL CANCER INSTITUTE 2012;104(17):1335-42

The impact of plasma preparations and their storage time on short-term posttransfusion mortality: A population-based study using the Scandinavian Donation and Transfusion database
Norda R, Andersson Tml, Edgren G, Nyren O, Reilly M
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY 2012;72(4):954-60

[The risk of acute readmission can be predicted. Former care consumption patterns and certain diagnoses are strongly predictive]
Stäck P, Forsberg B, Högberg M, Werr J, Edgren G
Lakartidningen 2012;109(48):2211-5

[TRALI is an overlooked transfusion reaction. Can be life-threatening, increased knowledge among Swedish physicians is needed]
Halmin M, Wikman At, Edgren G
Lakartidningen 2012;109(1-2):34-7

Response to "Alternate analysis strategies for retrospective assessment of outcomes with a male donor-only plasma policy" by Welsby, Stafford-Smith, and Phillips-Bute
Reilly M, Nyren O, Andersson Tml, Edgren G, Norda R, Shanwell A, et al
TRANSFUSION 2011;51(2):445-446

Time Trends in Risk and Risk Determinants of Non-Hodgkin Lymphoma in Solid Organ Transplant Recipients
Fernberg P, Edgren G, Adami J, Ingvar A, Bellocco R, Tufveson G, et al
AMERICAN JOURNAL OF TRANSPLANTATION 2011;11(11):2472-82

Diagnostic work-up of contralateral breast cancers has not improved over calendar period
Sandberg Mec, Hartman M, Edgren G, Eloranta S, Ploner A, Hall P, et al
BREAST CANCER RESEARCH AND TREATMENT 2010;122(3):889-95

Duration of red blood cell concentrate storage and survival of transfused patients. (vol 50, pg 1185, 2010)
Edgren G, Kamper-jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullman H, et al
TRANSFUSION 2010;50(8):1857-1857

Duration of red blood cell storage and survival of transfused patients (CME)
Edgren G, Kamper-jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullum H, et al
TRANSFUSION 2010;50(6):1185-95

Epidemiological considerations for the use of databases in transfusion research: a Scandinavian perspective
Edgren G, Hjalgrim H
CURRENT OPINION IN HEMATOLOGY 2010;17(6):596-601

Expensive blood safety initiatives may offer less benefit than we think
Kamper-jorgensen M, Hjalgrim H, Edgren G, Titlestad K, Ullum H, Shanwell A, et al
TRANSFUSION 2010;50(1):240-2

FREQUENCY OF BLOOD DONATION DOES NOT AFFECT BLOOD DONOR SURVIVAL
Ullum H, Kamper-jorgensen M, Edgren G, Rostgaard K, Melbye M, Nyren O, et al
VOX SANGUINIS 2010;:184-185

Pattern of declining hemoglobin concentration before cancer diagnosis
Edgren G, Bagnardi V, Bellocco R, Hjalgrim H, Rostgaard K, Melbye M, et al
INTERNATIONAL JOURNAL OF CANCER 2010;127(6):1429-36

Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study
Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al
AMERICAN JOURNAL OF EPIDEMIOLOGY 2010;172(11):1280-5

Should plasma from female donors be avoided? A population-based cohort study of plasma recipients in Sweden from 1990 through 2002
Tynell E, Andersson Tm, Norda R, Edgren G, Nyren O, Shanwell A, et al
TRANSFUSION 2010;50(6):1249-56

THE ASSOCIATION BETWEEN THE TYPES OF LABILE BLOOD COMPONENTS TRANSFUSED AND RECIPIENT MORTALITY
Custer S, Kamper-jorgensen M, Rostgaard K, Edgren G
VOX SANGUINIS 2010;:228-228

Blood transfusion exposure in Denmark and Sweden
Kamper-jorgensen M, Edgren G, Rostgaard K, Biggar Rj, Nyren O, Reilly M, et al
TRANSFUSION 2009;49(5):888-94

Post-transfusion mortality among recipients of ABO-compatible but non-identical plasma
Shanwell A, Andersson Tml, Rostgaard K, Edgren G, Hjalgrim H, Norda R, et al
VOX SANGUINIS 2009;96(4):316-23

Socioeconomic Differences in Patient Survival Are Increasing for Acute Myeloid Leukemia and Multiple Myeloma in Sweden
Kristinsson Sy, Derolf Ar, Edgren G, Dickman Pw, Bjorkholm M
JOURNAL OF CLINICAL ONCOLOGY 2009;27(12):2073-80

Blood transfusion exposure in Denmark and Sweden
Kamper-jorgensen M, Rostgaard K, Biggar R, Edgren G, Nyren O, Reilly M, et al
TRANSFUSION 2008;48(2):202A-202A

Breast cancer onset in twins and women with bilateral disease
Hartman M, Hall P, Edgren G, Reilly M, Lindstrom L, Lichtenstein P, et al
JOURNAL OF CLINICAL ONCOLOGY 2008;26(25):4086-91

Cancer as a ferrotoxic disease: Are we getting hard stainless evidence?
Edgren G, Nyren O, Melbye M
JOURNAL OF THE NATIONAL CANCER INSTITUTE 2008;100(14):976-7

Donation frequency, iron loss, and risk of cancer among blood donors
Edgren G, Reilly M, Hjalgrim H, Tran Tn, Rostgaard K, Adami J, et al
JOURNAL OF THE NATIONAL CANCER INSTITUTE 2008;100(8):572-9

Survival after blood transfusion
Kamper-jorgensen M, Ahlgren M, Rostgaard K, Melbye M, Edgren G, Nyren O, et al
TRANSFUSION 2008;48(12):2577-84

Survival after blood transfusion
Kamper-jargensen M, Ahlgren M, Rostgaard K, Edgren G, Nyren O, Reilly M, et al
TRANSFUSION 2008;48(2):206A-206A

Cancer incidence in blood transfusion recipients
Hjalgrim H, Edgren G, Rostgaard K, Reilly M, Tran Tn, Titlestad Ke, et al
JOURNAL OF THE NATIONAL CANCER INSTITUTE 2007;99(24):1864-74

Improving health profile of blood donors as a consequence of transfusion safety efforts
Edgren G, Tran Tn, Hjalgrim H, Rostgaard K, Shanwell A, Titlestad K, et al
TRANSFUSION 2007;47(11):2017-24

Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study
Edgren G, Sparen P
LANCET ONCOLOGY 2007;8(4):311-6

Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study
Edgren G, Hjalgrim H, Reilly M, Tran Tn, Rostgaard K, Shanwell A, et al
LANCET 2007;369(9574):1724-30

Risk of cancer from blood donated by people with cancer - Reply
Nyren O, Edgren G, Hjalgrim H, Reilly M, Melbye M
LANCET 2007;370(9587):563-564

A population-based binational register for monitoring long-term outcome and possible disease concordance among blood donors and recipients
Edgren G, Hjalgrim H, Tran Tn, Rostgaard K, Shanwell A, Titlestad K, et al
VOX SANGUINIS 2006;91(4):316-23

Survival after blood transfusion - A study of more than one mill on transfusion recipients
Titlestad K, Ahlgren M, Hjalgrim H, Rostgaard Petersen K, Shanwell A, Edgren G, et al
VOX SANGUINIS 2006;:27-27

[Health care services during summer--a dilemma?]
Nordenvall C, Edgren G, Gillispie A, Larsson M, Adami J, Johansson A, et al
Lakartidningen 2004;101(4):290-2

[Medical students' requirements: Make the medical education more scientific!]
Edgren G
Lakartidningen 2002;99(41):4078-9

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