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Bertrand Joseph

Professor

Besöksadress : Cancer Center Karolinska, R8:03; Karolinska Universitetssjukhuset Solna, 171 76 STOCKHOLM
Postadress : Institutionen för onkologi-patologi (OnkPat), K7, Forskargrupp Joseph, Bertrand, Cancer Center Karolinska, R8:03; Karolinska Universitetssjukhuset Solna, 171 76 STOCKHOLM
Leveransadress : Cancer Center Karolinska, R8:03; Karolinska Universitetssjukhuset Solna, 171 76 STOCKHOLM

Publikationer

Caspase-8 inhibition represses initial human monocyte activation in septic shock model
Oliva-martin Mj, Sanchez-abarca Li, Rodhe J, Carrillo-jimenez A, Vlachos P, Herrera Aj, et al
ONCOTARGET 2016;7(25):37456-37470

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky Dj, Abdelmohsen K, Abe A, Abedin Mj, Abeliovich H, Arozena Aa, et al
AUTOPHAGY 2016;12(1):1-222

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
Kavanagh E, Burguillos Ma, Carrillo-jimenez A, Oliva-martin Mj, Santiago M, Rodhe J, et al
Aging 2015;7(9):673-89

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi L, Bravo-san Pedro Jm, Vitale I, Aaronson Sa, Abrams Jm, Adam D, et al
CELL DEATH AND DIFFERENTIATION 2015;22(1):58-73

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
Burguillos Ma, Svensson M, Schulte T, Boza-serrano A, Garcia-quintanilla A, Kavanagh E, et al
CELL REPORTS 2015;10(9):1626-1638

Neuroinflammation in Alzheimer's disease
Heneka Mt, Carson Mj, El Khoury J, Landreth Ge, Brosseron F, Feinstein Dl, et al
The Lancet. Neurology 2015;14(4):388-405

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
Viceconte N, Burguillos Ma, Herrera Aj, De Pablos Rm, Joseph B, Venero Jl
JOURNAL OF NEUROINFLAMMATION 2015;:5-

Rph1/KDM4 mediates nutrient-limitation signaling that leads to the transcriptional induction of autophagy
Bernard A, Jin M, González-rodríguez P, Füllgrabe J, Delorme-axford E, Backues Sk, et al
Current biology : CB 2015;25(5):546-55

Cracking the survival code: autophagy-related histone modifications
Füllgrabe J, Heldring N, Hermanson O, Joseph B
Autophagy 2014;10(4):556-61

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats
Sjöqvist S, Jungebluth P, Lim Ml, Haag Jc, Gustafsson Y, Lemon G, et al
Nature communications 2014;5():3562-

Preservation of aortic root architecture and properties using a detergent-enzymatic perfusion protocol
Friedrich Lh, Jungebluth P, Sjöqvist S, Lundin V, Haag Jc, Lemon G, et al
Biomaterials 2014;35(6):1907-13

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia
Kavanagh E, Rodhe J, Burguillos Ma, Venero Jl, Joseph B
CELL DEATH & DISEASE 2014;:e1565-

The return of the nucleus: transcriptional and epigenetic control of autophagy
Fullgrabe J, Klionsky Dj, Joseph B
NATURE REVIEWS MOLECULAR CELL BIOLOGY 2014;15(1):65-74

A brief overview of multitalented microglia
Joseph B, Venero Jl
Methods in molecular biology (Clifton, N.J.) 2013;1041():3-8

Caspases playing in the field of neuroinflammation: old and new players
Venero Jl, Burguillos Ma, Joseph B
Developmental neuroscience 2013;35(2-3):88-101

TAp73β-mediated suppression of cell migration requires p57Kip2 control of actin cytoskeleton dynamics
Rodhe J, Kavanagh E, Joseph B
Oncotarget 2013;4(2):289-97

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy
Füllgrabe J, Lynch-day Ma, Heldring N, Li W, Struijk Rb, Ma Q, et al
Nature 2013;500(7463):468-71

Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky Dj, Abdalla Fc, Abeliovich H, Abraham Rt, Acevedo-arozena A, Adeli K, et al
AUTOPHAGY 2012;8(4):445-544

p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect
Kavanagh E, Vlachos P, Emourgeon V, Rodhe J, Joseph B
CELL DEATH & DISEASE 2012;:e311-

Pitx2 Expression Promotes p21 Expression and Cell Cycle Exit in Neural Stem Cells
Heldring N, Joseph B, Hermanson O, Kioussi C
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 2012;11(7):884-92

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus Evidence in Parkinson's disease patients
Burguillos Ma, Hajji N, Englund E, Persson A, Cenci Am, Machado A, et al
NEUROBIOLOGY OF DISEASE 2011;41(1):177-88

Caspase signalling controls microglia activation and neurotoxicity
Burguillos Ma, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-quintanilla A, et al
NATURE 2011;472(7343):319-24

Histone onco-modifications
Fullgrabe J, Kavanagh E, Joseph B
ONCOGENE 2011;30(31):3391-403

Hsp72 mediates TAp73 alpha anti-apoptotic effects in small cell lung carcinoma cells
Nyman U, Muppani Nr, Zhivotovsky B, Joseph B
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2011;15(8):1757-68

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death
Muppani N, Nyman U, Joseph B
ONCOTARGET 2011;2(12):1145-54

The executioners sing a new song: killer caspases activate microglia
Venero Jl, Burguillos Ma, Brundin P, Joseph B
CELL DEATH AND DIFFERENTIATION 2011;18(11):1679-91

The hallmarks of CDKN1C (p57, KIP2) in cancer
Kavanagh E, Joseph B
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 2011;1816(1):50-6

Cracking the death code: apoptosis-related histone modifications
Fullgrabe J, Hajji N, Joseph B
CELL DEATH AND DIFFERENTIATION 2010;17(8):1238-43

Epigenetic regulation of cell life and death decisions and deregulation in cancer
Hajji N, Joseph B
ESSAYS IN BIOCHEMISTRY: EPIGENETICS, DISEASE AND BEHAVIOUR 2010;:121-46

Molecular control of brain size: Regulators of neural stem cell life, death and beyond
Joseph B, Hermanson O
EXPERIMENTAL CELL RESEARCH 2010;316(8):1415-21

Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
Hajji N, Wallenborg K, Vlachos P, Fullgrabe J, Hermanson O, Joseph B
ONCOGENE 2010;29(15):2192-204

Proinsulin C-peptide Regulates Ribosomal RNA Expression
Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2010;285(5):3462-9

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D
Ballot C, Kluza J, Martoriati A, Nyman U, Formstecher P, Joseph B, et al
MOLECULAR CANCER THERAPEUTICS 2009;8(12):3307-17

p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells
Joseph B, Andersson Er, Vlachos P, Sodersten E, Liu L, Teixeira Ai, et al
CELL DEATH AND DIFFERENTIATION 2009;16(9):1256-65

Protein Kinase C-Dependent Phosphorylation Regulates the Cell Cycle-Inhibitory Function of the p73 Carboxy Terminus Transactivation Domain
Nyman U, Vlachos P, Cascante A, Hermanson O, Zhivotovsky B, Joseph B
MOLECULAR AND CELLULAR BIOLOGY 2009;29(7):1814-25

Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1
Wallenborg K, Vlachos P, Eriksson S, Huijbregts L, Arner Esj, Joseph B, et al
EXPERIMENTAL CELL RESEARCH 2009;315(8):1360-71

The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics
Vlachos P, Joseph B
ONCOGENE 2009;28(47):4175-88

The mitochondrial death pathway: a promising therapeutic target in diseases
Gupta S, Kass Gen, Szegezdi E, Joseph B
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2009;13(6):1004-33

Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells
Hajji N, Wallenborg K, Vlachos P, Nyman U, Hermanson O, Joseph B
ONCOGENE 2008;27(22):3134-44

Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GaIR2)
Tofighi R, Joseph B, Xia S, Xu Zqd, Hamberger B, Hokfelt T, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(7):2717-22

Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
Panaretakis T, Hjortsberg L, Tamm Kp, Bjorklund Ac, Joseph B, Grander D
MOLECULAR BIOLOGY OF THE CELL 2008;19(1):41-50

Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway
Gallego Ma, Ballot C, Kluza J, Hajji N, Martoriati A, Castera L, et al
ONCOGENE 2008;27(14):1981-92

Cellular internalization of proinsulin C-peptide
Lindahl E, Nyman U, Melles E, Sigmundsson K, Stahlberg M, Wahren J, et al
CELLULAR AND MOLECULAR LIFE SCIENCES 2007;64(4):479-86

The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway
Vlachos P, Nyman U, Hajji N, Joseph B
CELL DEATH AND DIFFERENTIATION 2007;14(8):1497-507

The role of p73 in hematological malignancies
Pluta A, Nyman U, Joseph B, Robak T, Zhivotovsky B, Smolewski P
LEUKEMIA 2006;20(5):757-66

Full-length p73 alpha represses drug-induced apoptosis in small cell lung carcinoma cells
Nyman U, Sobczak-pluta A, Vlachos P, Perlmann T, Zhivotovsky B, Joseph B
JOURNAL OF BIOLOGICAL CHEMISTRY 2005;280(40):34159-69

PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage
Hemstrom Th, Joseph B, Schulte G, Lewensohn R, Zhivotovsky B
EXPERIMENTAL CELL RESEARCH 2005;305(1):200-13

Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
Gallego Ma, Joseph B, Hemstrom Th, Tamiji S, Mortier L, Kroemer G, et al
ONCOGENE 2004;23(37):6282-91

Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha
Evstafieva Ag, Belov Ga, Rubtsov Yp, Kalkum M, Joseph B, Chichkova Nv, et al
EXPERIMENTAL CELL RESEARCH 2003;284(2):211-23

Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells
Ekedahl J, Joseph B, Marchetti P, Fauvel H, Formstecher P, Lewensohn R, et al
CANCER BIOLOGY & THERAPY 2003;2(6):663-9

Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
Hermanson E, Joseph B, Castro D, Lindqvist E, Aarnisalo P, Wallen A, et al
EXPERIMENTAL CELL RESEARCH 2003;288(2):324-34

p57(Kip2) cooperates with Nurr1 in developing dopamine cells
Joseph B, Wallen-mackenzie A, Benoit G, Murata T, Joodmardi E, Okret S, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003;100(26):15619-24

The novel retinoid AHPN/CD437 induces a rapid but incomplete apoptotic response in human myeloma cells
Joseph B, Marchetti P, Lefebvre O, Schraen-maschke S, Mereau-richard C, Formstecher P
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2003;1593(2-3):277-82

Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells
Ekedahl J, Joseph B, Grigoriev My, Muller M, Magnusson C, Lewensohn R, et al
EXPERIMENTAL CELL RESEARCH 2002;279(2):277-90

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
Joseph B, Marchetti P, Formstecher P, Kroemer G, Lewensohn R, Zhivotovsky B
ONCOGENE 2002;21(1):65-77

Defective caspase-3 relocalization in non-small cell lung carcinoma
Joseph B, Ekedahl J, Lewensohn R, Marchetti P, Formstecher P, Zhivotovsky B
ONCOGENE 2001;20(23):2877-88

Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrow cells isolated from patients with refractory anemia with ringed sideroblasts
Schmidt-mende J, Tehranchi R, Forsblom Am, Joseph B, Christensson B, Fadeel B, et al
LEUKEMIA 2001;15(5):742-51

High-LET radiation induces apoptosis in lymphoblastoid cell lines derived from ataxia-telangiectasia patients
Meijer Ae, Ekedahl J, Joseph B, Castro J, Harms-ringdahl M, Zhivotovsky B, et al
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 2001;77(3):309-17

Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells
Castro Ds, Hermanson E, Joseph B, Wallen A, Aarnisalo P, Heller A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(46):43277-84

Freezing induces artificial cleavage of apoptosis-related proteins in human bone marrow cells
Schmidt-mende J, Hellstrom-lindberg E, Joseph B, Zhivotovsky B
JOURNAL OF IMMUNOLOGICAL METHODS 2000;245(1-2):91-4

Role of apoptosis in the response of lung carcinomas to anti-cancer treatment
Joseph B, Lewensohn R, Zhivotovsky B
MECHANISMS OF CELL DEATH II 2000;:204-16

Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma
Joseph B, Ekedahl J, Sirzen F, Lewensohn R, Zhivotovsky B
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1999;262(2):381-7

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus
Marchetti P, Zamzami N, Joseph B, Schraen-maschke S, Mereau-richard C, Costantini P, et al
CANCER RESEARCH 1999;59(24):6257-66

Tumor radiosensitivity and apoptosis
Zhivotovsky B, Joseph B, Orrenius S
EXPERIMENTAL CELL RESEARCH 1999;248(1):10-7

Evidence for the involvement of both retinoic acid receptor- and retinoic X receptor-dependent signaling pathways in the induction of tissue transglutaminase and apoptosis in the human myeloma cell line RPMI 8226
Joseph B, Lefebvre O, Mereau-richard C, Danze Pm, Belin-plancot Mt, Formstecher P
BLOOD 1998;91(7):2423-32

mRNA expression of HNF-4 isoforms and of HNF-1 alpha/HNF-1 beta variants and differentiation of human cell lines that mimic highly specialized phenotypes of intestinal epithelium
Suaud L, Joseph B, Formstecher P, Laine B
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1997;235(3):820-5

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