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Anders Lindén

Professor/överläkare

Besöksadress : Nobelsväg 13 Solna
Postadress : Institutet för miljömedicin (IMM), C6, Lung och luftvägsforskning, Box 210 171 77 Stockholm
Leveransadress : Nobelsväg 13 Solna

Publikationer

Interleukin-26: An Emerging Player in Host Defense and Inflammation
Tengvall S, Che Kf, Lindén A
Journal of innate immunity 2016;8(1):15-22

The cytokine interleukin-26 as a biomarker in pediatric asthma
Konradsen Jr, Nordlund B, Levänen B, Hedlin G, Linden A
Respiratory research 2016;17():32-

Comorbidity and health-related quality of life in patients with severe chronic obstructive pulmonary disease attending Swedish secondary care units
Sundh J, Johansson G, Larsson K, Lindén A, Löfdahl Cg, Janson C, et al
International journal of chronic obstructive pulmonary disease 2015;10():173-83

Systemic cytokine signaling via IL-17 in smokers with obstructive pulmonary disease: a link to bacterial colonization?
Andelid K, Tengvall S, Andersson A, Levänen B, Christenson K, Jirholt P, et al
International journal of chronic obstructive pulmonary disease 2015;10():689-702

Systemic signs of neutrophil mobilization during clinically stable periods and during exacerbations in smokers with obstructive pulmonary disease
Andelid K, Andersson A, Yoshihara S, Åhrén C, Jirholt P, Ekberg-jansson A, et al
International journal of chronic obstructive pulmonary disease 2015;10():1253-63

The phenotype of concurrent chronic bronchitis and frequent exacerbations in patients with severe COPD attending Swedish secondary care units
Sundh J, Johansson G, Larsson K, Lindén A, Löfdahl Cg, Sandström T, et al
International journal of chronic obstructive pulmonary disease 2015;10():2327-34

Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with Löfgren's syndrome
Ostadkarampour M, Eklund A, Moller D, Glader P, Olgart Höglund C, Lindén A, et al
Clinical and experimental immunology 2014;178(2):342-52

Interleukin-17 cytokine signalling in patients with asthma
Lindén A, Dahlén B
The European respiratory journal 2014;44(5):1319-31

Interleukin-26 in Antibacterial Host Defense of Human Lungs Effects on Neutrophil Mobilization
Che Kf, Tengvall S, Levanen B, Silverpil E, Smith Me, Awad M, et al
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2014;190(9):1022-31

Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects
Smith Me, Bozinovski S, Malmhäll C, Sjöstrand M, Glader P, Venge P, et al
PloS one 2013;8(9):e75032-

Interleukin-22 produced by alveolar macrophages during activation of the innate immune response
Hansson M, Silverpil E, Lindén A, Glader P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013;62(6):561-9

Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation
Silverpil E, Wright Ak, Hansson M, Jirholt P, Henningsson L, Smith Me, et al
Innate immunity 2013;19(5):479-92

IL-17 in human asthma
Silverpil E, Linden A
EXPERT REVIEW OF RESPIRATORY MEDICINE 2012;6(2):173-86

A gender difference in circulating neutrophils in malnourished patients with COPD
Larsson S, Nordenson A, Glader P, Yoshihara S, Lindén A, Slinde F
International journal of chronic obstructive pulmonary disease 2011;6():83-8

Effects of tobacco smoke on IL-16 in CD8(+) cells from human airways and blood: a key role for oxygen free radicals?
Andersson A, Bossios A, Malmhall C, Sjostrand M, Eldh M, Eldh Bm, et al
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2011;300(1):L43-55

H-1 and hyperpolarized He-3 magnetic resonance imaging clearly detect the preventative effect of a glucocorticoid on endotoxin-induced pulmonary inflammation in vivo
Olsson Le, Smailagic A, Onnervik Po, Linden A, Hockings Pd
INNATE IMMUNITY 2011;17(2):204-11

[How the care of COPD will be better]
Larsson K, Löfdahl Cg, Lindén A, Sandström T, Johansson Gs
Lakartidningen 2011;108(35):1604-5

Impact of Interleukin-17 on Macrophage Phagocytosis of Apoptotic Neutrophils and Particles
Silverpil E, Glader P, Hansson M, Linden A
INFLAMMATION 2011;34(1):1-9

Increased net gelatinase but not serine protease activity in bronchiolitis obliterans syndrome
Riise Gc, Ericson P, Bozinovski S, Yoshihara S, Anderson Gp, Linden A
JOURNAL OF HEART AND LUNG TRANSPLANTATION 2010;29(7):800-7

Interleukin-17A during Local and Systemic Staphylococcus aureus-Induced Arthritis in Mice
Henningsson L, Jirholt P, Lindholm C, Eneljung T, Silverpil E, Iwakura Y, et al
INFECTION AND IMMUNITY 2010;78(9):3783-90

Interleukin-17-producing T-helper cells and related cytokines in human airways exposed to endotoxin
Glader P, Smith Me, Malmhall C, Balder B, Sjostrand M, Qvarfordt I, et al
EUROPEAN RESPIRATORY JOURNAL 2010;36(5):1155-64

Neutralizing Granulocyte/Macrophage Colony-Stimulating Factor Inhibits Cigarette Smoke-induced Lung Inflammation
Vlahos R, Bozinovski S, Chan Spj, Ivanov S, Linden A, Hamilton Ja, et al
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2010;182(1):34-40

IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo - effects of anti-inflammatory pharmacotherapy
Prause O, Bossios A, Silverpil E, Ivanov S, Bozinovski S, Vlahos R, et al
PULMONARY PHARMACOLOGY & THERAPEUTICS 2009;22(3):199-207

Impact of IL-17 on cells of the monocyte lineage in health and disease
Sergejeva S, Lindén A
Endocrine, metabolic & immune disorders drug targets 2009;9(2):178-86

Interleukin-17 as a drug target in human disease
Ivanov S, Linden A
TRENDS IN PHARMACOLOGICAL SCIENCES 2009;30(2):95-103

West Sweden Asthma Study: Prevalence trends over the last 18 years argues no recent increase in asthma
Lotvall J, Ekerljung L, Ronmark Ep, Wennergren G, Linden A, Ronmark E, et al
RESPIRATORY RESEARCH 2009;:94-

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space
Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, et al
EUROPEAN RESPIRATORY JOURNAL 2008;32(3):644-50

Prolonged eosinophil production after allergen exposure in IFN-gamma R KO mice is IL-5 dependent
Zhao Ll, Lotvall J, Linden A, Tomaki M, Sjostrand M, Bossios A
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;67(5):480-8

The IL-17 family of cytokines--applications in respiratory medicine and allergology
Laan M, Linden A
Recent patents on inflammation & allergy drug discovery 2008;2(2):82-91

A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling
Lindén A
Science's STKE : signal transduction knowledge environment 2007;2007(398):re4-

Functional relevance of the IL-23-IL-17 axis in lungs in vivo
Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, et al
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2007;36(4):442-51

Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms
Andelid K, Bake B, Rak S, Linden A, Rosengren A, Ekberg-jansson A
RESPIRATORY MEDICINE 2007;101(5):888-95

Th-17 cells in the lungs?
Ivanov S, Lindén A
Expert review of respiratory medicine 2007;1(2):279-93

Association of epithelial damage and signs of neutrophil mobilization in the airways during acute exacerbations of paediatric asthma
Yoshihara S, Yamada Y, Abe T, Linden A, Arisaka O
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2006;144(2):212-6

Interleukin-17 and airway remodelling
Linden A
PULMONARY PHARMACOLOGY & THERAPEUTICS 2006;19(1):47-50

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust
Ivanov S, Palmberg L, Venge P, Larsson K, Lindén A
Respiratory research 2005;6():44-

Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation
Sergejeva S, Ivanov S, Lotvall J, Linden A
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2005;33(3):248-53

Neutrophils, interleukin-17A and lung disease
Linden A, Laan M, Anderson Gp
EUROPEAN RESPIRATORY JOURNAL 2005;25(1):159-72

A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo
Sergejeva S, Hoshino H, Yoshihara S, Kashimoto K, Lotvall J, Linden A
REGULATORY PEPTIDES 2004;117(2):149-54

BAL levels of interleukin-18 do not change before or during acute rejection in lungtransplant recipients
Ericson P, Linden A, Riise Gc
RESPIRATORY MEDICINE 2004;98(2):159-63

beta-adrenoceptor stimulation and neutrophil accumulation in mouse airways
Miyamoto M, Tomaki M, Lotvall J, Linden A
EUROPEAN RESPIRATORY JOURNAL 2004;24(2):231-7

Impact of tobacco smoke on interleukin-16 protein in human airways, lymphoid tissue and T lymphocytes
Andersson A, Qvarfordt I, Laan M, Sjostrand M, Malmhall C, Riise Gc, et al
Clinical and experimental immunology 2004;138(1):75-82

Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways
Prause O, Bozinovski S, Anderson Gp, Linden A
THORAX 2004;59(4):313-7

Interleukin-17 family members and inflammation
Kolls Jk, Linden A
IMMUNITY 2004;21(4):467-76

Long-lasting smooth-muscle relaxation by a novel PACAP analogue in human bronchi
Yoshihara S, Yamada Y, Abe T, Kashimoto K, Linden A, Arisaka O
REGULATORY PEPTIDES 2004;123(1-3):161-5

A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha
Laan M, Prause O, Miyamoto M, Sjostrand M, Hytonen Am, Kaneko T, et al
EUROPEAN RESPIRATORY JOURNAL 2003;21(3):387-93

Bronchodilation by an inhaled VPAC(2) receptor agonist in patients with stable asthma
Linden A, Hansson L, Andersson A, Palmqvist M, Arvidsson P, Lofdahl Cg, et al
THORAX 2003;58(3):217-21

Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways
Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
JOURNAL OF IMMUNOLOGY 2003;170(9):4665-72

IL-16 in the airways of lung allograft recipients with acute rejection or obliterative bronchiolitis
Laan M, Linden A, Riise Gc
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2003;133(2):290-6

Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells
Prause O, Laan M, Lotvall J, Linden A
EUROPEAN JOURNAL OF PHARMACOLOGY 2003;462(1-3):193-8

Rationale for targeting interleukin-17 in the lungs
Lindén A
Current opinion in investigational drugs (London, England : 2000) 2003;4(11):1304-12

Comparison of effects of Anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen
Tomaki M, Zhao Ll, Sjostrand M, Linden A, Ichinose M, Lotvall J
PULMONARY PHARMACOLOGY & THERAPEUTICS 2002;15(2):161-8

Free, soluble interleukin-17 protein during severe inflammation in human airways
Laan M, Palmberg L, Larsson K, Lindén A
The European respiratory journal 2002;19(3):534-7

IL-17 as a potential target for modulating airway neutrophilia
Laan M, Linden A
CURRENT PHARMACEUTICAL DESIGN 2002;8(20):1855-61

Neutrophilic airway inflammation and IL-17
Linden A, Adachi M
ALLERGY 2002;57(9):769-75

Effect of seasonal allergen exposure on mucosal IL-16 and CD4+cells in patients with allergic rhinitis
Pullerits T, Linden A, Malmhall C, Lotvall J
ALLERGY 2001;56(9):871-7

IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases
Laan M, Lotvall J, Chung Kf, Linden A
BRITISH JOURNAL OF PHARMACOLOGY 2001;133(1):200-6

Pituitary adenylate cyclase-activating peptide inhibits neutrophil chemotaxis
Kinhult J, Uddman R, Laan M, Lindén A, Cardell Lo
Peptides 2001;22(12):2151-4

Reduced late asthmatic response by repeated low-dose allergen exposure
Palmqvist M, Cui Zh, Sjostrand M, Linden A, Lotvall J
EUROPEAN RESPIRATORY JOURNAL 2001;17(5):872-80

Role of interleukin-17 and the neutrophil in asthma
Linden A
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 2001;126(3):179-84

Airway neutrophils and interleukin-17
Linden A, Hoshino H, Laan M
EUROPEAN RESPIRATORY JOURNAL 2000;15(5):973-7

Eosinophilopoiesis in a murine model of allergic airway eosinophilia: involvement of bone marrow IL-5 and IL-5 receptor alpha
Tomaki M, Zhao Ll, Lundahl J, Sjöstrand M, Jordana M, Lindén A, et al
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4040-50

IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure
Zhao Ll, Linden A, Sjostrand M, Cui Zh, Lotvall J, Jordana M
ALLERGY 2000;55(8):749-56

Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo
Hoshino H, Laan M, Sjostrand M, Lotvall J, Skoogh Be, Linden A
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2000;105(1):143-9

Upregulation of nasal mucosal eotaxin in patients with allergic rhinitis during grass pollen season: effect of a local glucocorticoid
Pullerits T, Lindén A, Praks L, Cardell Lo, Lötvall J
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(10):1469-75

Bronchodilation by pituitary adenylate cyclase-activating peptide and related peptides
Lindén A, Cardell Lo, Yoshihara S, Nadel Ja
The European respiratory journal 1999;14(2):443-51

Effect of nedocromil sodium on non-adrenergic, non-cholinergic neural responses in guinea pig bronchi in vitro
Linden A, Bergendal A, Lotvall J, Skoogh Be, Lofdahl Cg
REGULATORY PEPTIDES 1999;81(1-3):49-53

Increased levels of interleukin-16 in the airways of tobacco smokers: relationship with peripheral blood T lymphocytes
Laan M, Qvarfordt I, Riise Gc, Andersson Ba, Larsson S, Linden A
THORAX 1999;54(10):911-6

Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
Laan M, Cui Zh, Hoshino H, Lotvall J, Sjostrand M, Gruenert Dc, et al
JOURNAL OF IMMUNOLOGY 1999;162(4):2347-52

Neutrophil recruitment by interleukin-17 into rat airways in vivo - Role of tachykinins
Hoshino H, Lotvall J, Skoogh Be, Linden A
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 1999;159(5):1423-8

PACAPs - Potential for bronchodilation
Linden A
PULMONARY PHARMACOLOGY & THERAPEUTICS 1999;12(4):229-236

A novel long-acting VIP analog in the guinea pig trachea in vitro
Yoshihara S, Linden A, Kashimoto K, Watanabe S
PEPTIDES 1998;19(3):593-7

Bronchodilatation in vivo by carbon monoxide, a cyclic GMP related messenger
Cardell Lo, Ueki If, Stjärne P, Agusti C, Takeyama K, Lindén A, et al
British journal of pharmacology 1998;124(6):1065-8

Effect of a novel PACAP-27 analogue on muscarinic airway responsiveness in guinea-pigs in vivo
Okazawa A, Cui Zh, Lotvall J, Yoshihara S, Skoogh Be, Kashimoto K, et al
EUROPEAN RESPIRATORY JOURNAL 1998;12(5):1062-6

PACAP 1-38 as an inhaled bronchodilator in guinea pigs in vivo
Lindén A, Cardell Lo, Yoshihara S, Stjärne P, Nadel Ja
Peptides 1998;19(1):93-8

Sustained relaxant action of [Arg(15,20,21), Leu(17)]-PACAP-27-NH2 on carbachol-induced contraction of guinea-pig tracheal smooth muscle in vitro
Yamada Y, Yoshihara S, Kashimoto K, Linden A, Ichimura T
BIOMEDICAL RESEARCH-TOKYO 1998;19(1):39-44

Functional type II VIP-PACAP receptors in human airway epithelial-like cells
Lindén A, Yoshihara S, Cardell Lo, Kaneko T, Stjärne P, Nadel Ja
Peptides 1997;18(6):843-6

Long lasting smooth muscle relaxation by a novel PACAP analogue in guinea-pig and primate airways in vitro
Yoshihara S, Linden A, Kashimoto K, Nagano Y, Ichimura T, Nadel Ja
BRITISH JOURNAL OF PHARMACOLOGY 1997;121(8):1730-4

A novel PACAP 1-27 analogue causes sustained smooth muscle relaxation in guinea-pig trachea
Yoshihara S, Linden A, Kashimoto K, Nagano Y, Ichimura T, Nadel Ja
VIP, PACAP, AND RELATED PEPTIDES, 2ND INTERNATIONAL SYMPOSIUM 1996;:536-42

Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs
Yoshihara S, Geppetti P, Hara M, Linden A, Ricciardolo Flm, Chan B, et al
EUROPEAN JOURNAL OF PHARMACOLOGY 1996;296(3):291-6

Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways
Massion Pp, Linden A, Inoue H, Mathy M, Grattan Km, Nadel Ja
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1996;271(5):L838-43

Extent of salmeterol-mediated reassertion of relaxation in guineapig trachea pretreated with aliphatic side chain structural analogues
Bergendal A, Linden A, Skoogh Be, Gerspacher M, Anderson Gp, Lofdahl Cg
BRITISH JOURNAL OF PHARMACOLOGY 1996;117(6):1009-15

Increased interleukin-8 release by beta-adrenoceptor activation in human transformed bronchial epithelial cells
Linden A
BRITISH JOURNAL OF PHARMACOLOGY 1996;119(2):402-6

NANC neural control of airway smooth muscle tone
Linden A
GENERAL PHARMACOLOGY 1996;27(7):1109-21

Pharmacological basis for duration of effect: Formoterol and salmeterol versus short-acting beta(2)-adrenoceptor agonists
Linden A, Rabe Kf, Lofdahl Cg
LUNG 1996;174(1):1-22

Relaxation kinetics of formoterol and salmeterol in the guinea pig trachea in vitro
Anderson P, Lotvall J, Linden A
LUNG 1996;174(3):159-70

CORTICOTROPIN-RELEASING FACTOR INHIBITS ANTIGEN-INDUCED PLASMA EXTRAVASATION IN AIRWAYS
Yoshihara S, Ricciardolo Flm, Geppetti P, Linden A, Hara M, Chan B, et al
EUROPEAN JOURNAL OF PHARMACOLOGY 1995;280(2):113-8

DIFFERENT EFFECTS OF SALMETEROL, FORMOTEROL AND SALBUTAMOL ON CHOLINERGIC RESPONSES IN THE FERRET TRACHEA
Bergendal A, Linden A, Lotvall J, Skoogh Be, Lofdahl Cg
BRITISH JOURNAL OF PHARMACOLOGY 1995;114(7):1478-82

INHIBITION OF BRONCHOCONSTRICTION BY PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP-1-27) IN GUINEA-PIGS IN-VIVO
Linden A, Yoshihara S, Chan B, Nadel Ja
BRITISH JOURNAL OF PHARMACOLOGY 1995;115(6):913-6

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