Forskargrupp - Lennart Hammarström

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Vår forskning fokuserar kring immunbristgenetik och immunbristbehandling.

Genetisk bas för primär immunbrist

Hyper lgM syndrom (HIGM)
Variabel immunbrist
IgA brist (IgAD)

Uttryck av gener som kodar för antikroppar i laktobaciller

Lactobaciller (Rotavirus, Clostridium difficile, HIV)
Cytokiner (IL-10, IL-21)
Lingander (CD40L)

Forskargruppsledare Lennart Hammarström

Professor

Lennart Hammarström

Telefon: 08-524 835 86
Enhet: Avdelningen för Klinisk Immunologi o Transfusionsmedicin
E-post: Lennart.Hammarstrom@ki.se

Gruppmedlemmar

Hassan AbolhassaniDoktorand
Kerstin BergmanLaboratorietekniker
Mahya DezfouliAnknuten
Renée EnqvistAnknuten
Mingyan FangForskarstuderande
Lennart HammarströmProfessor
Jovanka KingDoktorand
Che Kang LimDoktorand
Annica LindkvistUniversitetsadjunkt
Harold MarcotteForskare
Jezabel Varadé Anknuten
Yu XiaAnknuten

Externa bidragsgivare

Vetenskapsrådet, EU, National Institutes of Health, ALF

Undervisningsuppdrag

BMA, läkarprogrammet, tandläkarprogrammet

Utvalda publikationer

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.
Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, et al
J. Clin. Invest. 2013 Sep;123(9):3829-38

Impact of Down syndrome on the performance of neonatal screening assays for severe primary immunodeficiency diseases.
Verstegen R, Borte S, Bok L, van Zwieten P, von Döbeln U, Hammarström L, et al
J. Allergy Clin. Immunol. 2014 Apr;133(4):1208-11

The dog as a genetic model for immunoglobulin A (IgA) deficiency: identification of several breeds with low serum IgA concentrations.
Olsson M, Frankowiack M, Tengvall K, Roosje P, Fall T, Ivansson E, et al
Vet. Immunol. Immunopathol. 2014 Aug;160(3-4):255-9

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.
Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis S, et al
Science 2013 May;340(6135):976-8

[pubmed:22130802]

Selective IgA deficiency in autoimmune diseases.
Wang N, Shen N, Vyse T, Anand V, Gunnarson I, Sturfelt G, et al
Mol. Med. 2011 ;17(11-12):1383-96

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
Ferreira R, Pan-Hammarström Q, Graham R, Gateva V, Fontán G, Lee A, et al
Nat. Genet. 2010 Sep;42(9):777-80

[pubmed:19846760]

Immunologi