Research projects are focused on examining the regenerative capacity of soft connective tissues within the oral cavity during health and disease. We are particularly concerned with the complications that result following hematopoietic stem cell transplantation in the form of Graft versus Host Disease. Oral manifestations are one of the most common and debilitating complications, and the histopathology poorly understood. Studies are ongoing to define the histopathological features of chronic graft versus host disease with the aim to couple clinical presentation to provide improved pathological diagnostics. The oral cavity has a huge potential to heal without scaring and many sources of cells have been identified in the soft tissues, including, gingiva, labial and buccal mucosal. A key to harnessing the cells potential and facilitating novel treatment strategies for cGVHD is to understand the stem cell niche and the role of the extracellular matrix (ECM) in maintaining this niche supporting the reparative process. Thus, research is also focusing on the role of the ECM in supporting the resident cell niche during wound healing and tissue repair, and regeneration of these tissues.
Victor Tollemar Wilmenius (Doctoral Student)
Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
STEM CELLS AND DEVELOPMENT 2007;16(1):39-52
Expression of HMGB1 during tooth development
CELL AND TISSUE RESEARCH 2007;327(3):511-9
Adsorption and interactions of dentine phosphoprotein with hydroxyapatite and collagen
EUROPEAN JOURNAL OF ORAL SCIENCES 2006;114(3):223-31
Substitution of bovine dentine sialoprotein with chondroitin sulfate glycosaminoglycan chains
EUROPEAN JOURNAL OF ORAL SCIENCES 2006;114(1):89-92
Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2006;1763(10):1031-9
Modulation of collagen fibrillogenesis by dentinal proteoglycans
CALCIFIED TISSUE INTERNATIONAL 2005;76(2):127-35
Dentinal proteoglycans demonstrate an increasing order of affinity for hydroxyapatite crystals during the transition of predentine to dentine
CALCIFIED TISSUE INTERNATIONAL 2004;75(3):197-204
Nucleobindin - a Ca2+-binding protein present in the cells and mineralized tissues of the tooth
CALCIFIED TISSUE INTERNATIONAL 2004;74(4):366-76
Organized development from human embryonic stem cells after injection into immunodeficient mice
STEM CELLS AND DEVELOPMENT 2004;13(4):421-35
Differential roles for small leucine-rich proteoglycans in bone formation
European cells & materials 2003;6():12-21
Functional roles for dentinal proteoglycans and their constituent glycosaminoglycans in regulating mineralization.
JOURNAL OF DENTAL RESEARCH 2003;:B76-B76
Identification, distribution, and expression of nucleobindin during tooth formation.
JOURNAL OF DENTAL RESEARCH 2003;:B77-B77
Molecular interaction of recombinant decorin and biglycan with type I collagen influences crystal growth
CONNECTIVE TISSUE RESEARCH 2003;:189-95
Real-time biomolecular interaction analysis of small leucine-rich proteoglycans with type 1 collagen.
JOURNAL OF DENTAL RESEARCH 2003;:490-490
TGF-beta/extracellular matrix interactions and dentin matrix.
JOURNAL OF DENTAL RESEARCH 2003;:B46-B46
The interaction of recombinant decorin with alpha 2HS-glycoprotein - Implications for structural and functional investigations
PROTEIN EXPRESSION AND PURIFICATION 2002;25(1):180-8
The interaction of truncated decorin forms in regulating collagen fibrillogenesis.
JOURNAL OF DENTAL RESEARCH 2002;:A439-A439
Modulation of hydroxyapatite seeded crystal growth by decorin and biglycan
JOURNAL OF DENTAL RESEARCH 2001;80(4):1181-1181
Evidence for interactions of mineralised tissue proteins with alpha(2) HS-glycoprotein during their purification.
JOURNAL OF DENTAL RESEARCH 2000;79(5):1176-1176
Characterisations of chondroitin sulphate rich recombinant decorin and biglycan proteoglycans
JOURNAL OF DENTAL RESEARCH 1999;78(5):1054-1054