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Niklas Zethraeus

Senior researcher

Visiting address : , Sweden
Postal address : Department of Learning, Informatics, Management and Ethics (LIME), C7, MMC/Health Economics and Economic Evaluation, Nobels väg 15A, 171 77 Stockholm, Sweden
Delivery address : , Sweden

About me

I'm an associate professor of health economics, working at MMC, LIME at Karolinska Institutet. I'm also the director of studies of the Master's programme of health economics, policy and mangagement.

Research description

The focus of my research is economic evaluation studies in different areas such as congestive heart failure, gallstone disease, osteoporosis and hormone replacement therapy. I'm also doing research in behavioural (health) economics, e.g., analysing the effects of hormones on economic behaviours and other clinical outcomes.

Publications

Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial
Zethraeus N, Dreber A, Ranehill E, Blomberg L, Labrie F, Von Schoultz B, et al
The Journal of clinical endocrinology and metabolism 2016;101(11):4046-4053

Cost-effectiveness of case-based training for primary care physicians in evidence-based medicine of patients with coronary heart disease
Groot-jensen S, Kiessling A, Zethraeus N, Björnstedt-bennermo M, Henriksson P
European journal of preventive cardiology 2016;23(4):420-7

Assessment of the Swedish EQ-5D experience-based value sets in a total hip replacement population
Nemes S, Burström K, Zethraeus N, Eneqvist T, Garellick G, Rolfson O
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2015;24(12):2963-70

Barriers to and facilitators of compliance with clinic-based cervical cancer screening: population-based cohort study of women aged 23-60 years
Östensson E, Alder S, Elfström Km, Sundström K, Zethraeus N, Arbyn M, et al
PloS one 2015;10(5):e0128270-

Cost and effects of a universal parenting programme delivered to parents of preschoolers
Sampaio F, Sarkadi A, Salari R, Zethraeus N, Feldman I
European journal of public health 2015;25(6):1035-42

Cost of Preventing, Managing, and Treating Human Papillomavirus (HPV)-Related Diseases in Sweden before the Introduction of Quadrivalent HPV Vaccination
Östensson E, Fröberg M, Leval A, Hellström Ac, Bäcklund M, Zethraeus N, et al
PloS one 2015;10(9):e0139062-

Integrative medicine for back and neck pain: Exploring cost-effectiveness alongside a randomized clinical pilot trial
Sundberg T, Hagberg L, Zethraeus N, Wandell P, Falkenberg T
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 2014;6(1):29-38

Swedish experience-based value sets for EQ-5D health states
Burström K, Sun S, Gerdtham Ug, Henriksson M, Johannesson M, Levin LÅ, et al
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2014;23(2):431-42

Projected cost-effectiveness of repeat high-risk human papillomavirus testing using self-collected vaginal samples in the Swedish cervical cancer screening program
Östensson E, Hellström Ac, Hellman K, Gustavsson I, Gyllensten U, Wilander E, et al
Acta obstetricia et gynecologica Scandinavica 2013;92(7):830-40

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
Kocoska-maras L, Zethraeus N, Raddestad Af, Ellingsen T, Von Schoultz B, Johannesson M, et al
FERTILITY AND STERILITY 2011;95(1):152-7

Economic analysis of human papillomavirus triage, repeat cytology, and immediate colposcopy in management of women with minor cytological abnormalities in Sweden
Ostensson E, Froberg M, Hjerpe A, Zethraeus N, Andersson S
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2010;89(10):1316-25

Health-care cost reduction resulting from primary-care allergy testing in children in Italy
Zethraeus N, Petersson Cj, Dozzi M, Borres Mp, Vignati G, Fiocchi A
ITALIAN JOURNAL OF PEDIATRICS 2010;:61-

A randomized trial of the effect of estrogen and testosterone on economic behavior
Zethraeus N, Kocoska-maras L, Ellingsen T, Von Schoultz B, Hirschberg Al, Johannesson M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(16):6535-8

Cost-effectiveness of hormone replacement therapy for menopausal symptoms in the UK
Lekander I, Borgström F, Ström O, Zethraeus N, Kanis Ja
Menopause international 2009;15(1):19-25

Cost-Effectiveness of Hormone Therapy in the United States
Lekander I, Borgstrom F, Strom O, Zethraeus N, Kanis Ja
JOURNAL OF WOMENS HEALTH 2009;18(10):1669-77

Cost effectiveness of hormone therapy in women at high risks of fracture in Sweden, the US and the UK - Results based on the Women's Health Initiative randomised controlled trial
Lekander I, Borgstrom F, Strom O, Zethraeus N, Kanis Ja
BONE 2008;42(2):294-306

Long-term cost and effect on quality of life of osteoporosis-related fractures in Sweden
Strom O, Borgstrom F, Zethraeus N, Johnell O, Lidgren L, Ponzer S, et al
ACTA ORTHOPAEDICA 2008;79(2):269-80

The cost-effectiveness of the treatment of high risk women with osteoporosis, hypertension and hyperlipidaemia in Sweden
Zethraeus N, Strom O, Borgstrom F, Kanis Ja, Jonsson B
OSTEOPOROSIS INTERNATIONAL 2008;19(6):819-27

Cost-effectiveness of the treatment and prevention of osteoporosis - a review of the literature and a reference model
Zethraeus N, Borgstrom F, Strom O, Kanis Ja, Jonsson B
OSTEOPOROSIS INTERNATIONAL 2007;18(1):9-23

Long term quality of life related to osteoporotic fractures. 13-18 months after fracture
Strom O, Borgstrom F, Zethraeus N, Johnell O, Jonsson B
OSTEOPOROSIS INTERNATIONAL 2007;:S6-S6

Cost consequences of preoperative duplex examination before varicose vein surgery: a randomized clinical trial
Blomgren L, Zethraeus N, Johansson G, Jonsson B, Bergqvist D
PHLEBOLOGY 2006;21(2):90-95

Cost-effectiveness analysis of using allergy tests in primary care in Italian children
Ytterstrom-ahlstedt U, Zethraeus N, Petersson Cj, Ahlstedt S
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2006;117(2):S135-S135

Costs and quality of life associated with osteoporosis-related fractures in Sweden
Borgstrom F, Zethraeus N, Johnell O, Lidgren L, Ponzer S, Svensson O, et al
OSTEOPOROSIS INTERNATIONAL 2006;17(5):637-50

Long term quality of life related to osteoporotic fractures; 13-18 months after fracture
Strom O, Borgstrom F, Zethraeus N, Jonsson B
VALUE IN HEALTH 2006;9(6):A383-A383

What is the risk of institutionalization after hip fracture?
Zethraeus N, Strom O, Borgstrom F
OSTEOPOROSIS INTERNATIONAL 2006;:S57-S58

What is the risk of institutionalization after hip fracture?
Zethraeus N, Strom Oe, Borgstrom F
OSTEOPOROSIS INTERNATIONAL 2006;:S184-S184

Assessment of fracture risk
Kanis Ja, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, et al
OSTEOPOROSIS INTERNATIONAL 2005;16(6):581-9

Cost of lipid lowering in patients with coronary artery disease by Case Method Learning
Kiessling A, Zethraeus N, Henriksson P
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 2005;21(2):180-6

Intervention thresholds for osteoporosis in the UK
Kanis Ja, Borgsrom F, Zethraeus N, Johnell O, Oden A, Jonsson B
BONE 2005;36(1):22-32

Reassessment of the cost-effectiveness of hormone replacement therapy in Sweden: Results based on the Women's Health Initiative randomized controlled trial
Zethraeus N, Borgstrom F, Jonsson B, Kanis J
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 2005;21(4):433-41

Case method learning is a cost effective implementation method of evidence based secondary prevention in primary care
Kiessling A, Zethraeus N, Henriksson P
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2004;43(5):408A-408A

Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden
Borgstrom F, Johnell O, Johnsson B, Zethraeus N, Sen Ss
BONE 2004;34(6):1064-71

Costs and quality of life related to vertebral fractures: Preliminary results based on an ongoing Swedish prospective study
Zethraeus N, Borgstrom F, Jonsson B
OSTEOPOROSIS INTERNATIONAL 2004;:S52-S53

The cost effectiveness of hormone replacement therapy (HRT) for women with menopasual symptoms in Sweden
Borgstrom F, Zethraeus N, Johnell O, Kanis J, Jonsson B
VALUE IN HEALTH 2004;7(6):691-692

The risk and burden of vertebral fractures in Sweden
Kanis Ja, Johnell O, Oden A, Borgstrom F, Zethraeus N, De Laet C, et al
OSTEOPOROSIS INTERNATIONAL 2004;15(1):20-6

Advantages of using the net-benefit approach for analysing uncertainty in economic evaluation studies
Zethraeus N, Johannesson M, Jonsson B, Lothgren M, Tambour M
PHARMACOECONOMICS 2003;21(1):39-48

[Cost-effectiveness of alendronate treatment of osteoporosis in Denmark. An economic evaluation based on the Fracture Intervention Trial]
Jönsson L, Borgström F, Zethraeus N
Ugeskrift for laeger 2003;165(43):4112-6

Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial
Cleland Jgf, Takala A, Apajasalo M, Zethraeus N, Kobelt G
EUROPEAN JOURNAL OF HEART FAILURE 2003;5(1):101-8

Modelling the cost-effectiveness of osteoporosis treatments the impact of patient compliance
Borgstrom F, Zethraeus N, Naujoks C
OSTEOPOROSIS INTERNATIONAL 2003;:S13-S13

Predicting survival in cost-effectiveness analyses based on clinical trials
Gerdtham Ug, Zethraeus N
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 2003;19(3):507-12

Femoral neck fractures in the elderly: Functional outcome and quality of life according to EuroQol
Tidermark J, Zethraeus N, Svensson O, Tornkvist H, Ponzer S
QUALITY OF LIFE RESEARCH 2002;11(5):473-81

Models for assessing the cost-effectiveness of the treatment and prevention of osteoporosis
Zethraeus N, Ben Sedrine W, Caulin F, Corcaud S, Gathon Hj, Haim M, et al
OSTEOPOROSIS INTERNATIONAL 2002;13(11):841-57

Sequential changes in quality of life after osteoporotic fractures
Johnell O, Kanis J, Delaet C, Jonsson B, Zethraeus N, Oden A
OSTEOPOROSIS INTERNATIONAL 2002;:S70-S70

Cost effectiveness of bisoprolol in the treatment of chronic congestive heart failure in Sweden - Analysis using data from the cardiac insufficiency bisoprolol study II trial
Ekman M, Zethraeus N, Jonsson B
PHARMACOECONOMICS 2001;19(9):901-16

Costs and benefits of laparoscopic surgery - a review of the literature
Jonsson B, Zethraeus N
EUROPEAN JOURNAL OF SURGERY 2000;:48-56

Costs and benefits of laparoscopic surgery--a review of the literature
Jönsson B, Zethraeus N
The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 2000;(585):48-56

Definition, interpretation and calculation of cost-effectiveness acceptability curves
Lothgren M, Zethraeus N
HEALTH ECONOMICS 2000;9(7):623-30

A comparison of patient and social tariff values derived from the time trade-off method
Zethraeus N, Johannesson M
HEALTH ECONOMICS 1999;8(6):541-5

A computer model to analyze the cost-effectiveness of hormone replacement therapy
Zethraeus N, Johannesson M, Jonsson B
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 1999;15(2):352-65

Costs of coronary heart disease and stroke: the case of Sweden
Zethraeus N, Molin T, Henriksson P, Jonsson B
JOURNAL OF INTERNAL MEDICINE 1999;246(2):151-9

A note on confidence intervals in cost-effectiveness analysis
Tambour M, Zethraeus N, Johannesson M
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 1998;14(3):467-71

Bootstrap confidence intervals for cost-effectiveness ratios: Some simulation results
Tambour M, Zethraeus N
HEALTH ECONOMICS 1998;7(2):143-7

Estimating the costs of hip fracture and potential savings
Zethraeus N, Gerdtham Ug
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 1998;14(2):255-67

Nonparametric willingness-to-pay measures and confidence statements
Tambour M, Zethraeus N
MEDICAL DECISION MAKING 1998;18(3):330-6

Willingness to pay for hormone replacement therapy
Zethraeus N
HEALTH ECONOMICS 1998;7(1):31-8

The cost of a hip fracture - Estimates for 1,709 patients in Sweden
Zethraeus N, Stromberg L, Jonsson B, Svensson O, Ohlen G
ACTA ORTHOPAEDICA SCANDINAVICA 1997;68(1):13-7

The impact of hormone replacement therapy on quality of life and willingness to pay
Zethraeus N, Johannesson M, Henriksson P, Strand Rt
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY 1997;104(10):1191-5

A cost-minimization analysis of laparoscopic cholecystectomy versus open cholecystectomy
Berggren U, Zethraeus N, Arvidsson D, Haglund U, Jonsson B
AMERICAN JOURNAL OF SURGERY 1996;172(4):305-10

VALUE FOR MONEY - A CONTINGENT VALUATION STUDY OF THE OPTIMAL SIZE OF THE SWEDISH HEALTH-CARE BUDGET
Eckerlund I, Johannesson M, Johansson Po, Tambour M, Zethraeus N
HEALTH POLICY 1995;34(2):135-43

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