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Maria Kippler

Assistant professor

Visiting address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden
Postal address : Institute of Environmental Medicine (IMM), C6, Metals and health, Box 210 171 77 Stockholm, Sweden
Delivery address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden

About me

Assistant Professor at Karolinska Institutet, Institute of Environmental Medicine, Unit of Metals and Health.

Education

PhD in Medical Science, Karolinska Institutet, 2009.

MSc in Toxicology, Karolinska Institutet, 2004.

Research description

The overall aim of the research in my research group is to increase the knowledge about how early-life exposure to environmental pollutants, especially metals like cadmium, can affect child health and development. We also study the role of essential trace elements and other nutrients (e.g. selenium and iodine) and whether interactions may occur with different toxic elements. This is achieved by combining epidemiological- and mechanistic studies within several different mother-child cohorts. Metals and other trace elements are mainly measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), which enables high-throughput analyses of multiple elements in the low-dose range. Effect biomarkers are measured with several different molecular techniques.

Links

Publications

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Raqib R, Ahmed S, Ahsan Kb, Kippler M, Akhtar E, Roy Ak, et al
Environmental health perspectives 2017;125(6):67006-

Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children
Skröder H, Kippler M, Nermell B, Tofail F, Levi M, Rahman Sm, et al
Environmental health perspectives 2017;125(6):67021-

Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study
Rahman Sm, Kippler M, Tofail F, Bölte S, Hamadani Jd, Vahter M
Environmental health perspectives 2017;125(5):57003-

Methylmercury exposure and cognitive abilities and behavior at 10years of age
Gustin K, Tofail F, Mehrin F, Levi M, Vahter M, Kippler M
Environment international 2017;102():97-105

Arsenic alters global histone modifications in lymphocytes in vitro and in vivo
Pournara A, Kippler M, Holmlund T, Ceder R, Grafström R, Vahter M, et al
Cell biology and toxicology 2016;32(4):275-84

Arsenic Metabolism in Children Differs From That in Adults
Skröder Löveborn H, Kippler M, Lu Y, Ahmed S, Kuehnelt D, Raqib R, et al
Toxicological sciences : an official journal of the Society of Toxicology 2016;152(1):29-39

Associations of dietary polychlorinated biphenyls and long-chain omega-3 fatty acids with stroke risk
Kippler M, Larsson Sc, Berglund M, Glynn A, Wolk A, Åkesson A
Environment international 2016;94():706-711

Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function
Wahlberg K, Kippler M, Alhamdow A, Rahman Sm, Smith Dr, Vahter M, et al
Toxicological sciences : an official journal of the Society of Toxicology 2016;149(2):473-83

Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort
Donat-vargas C, Åkesson A, Berglund M, Glynn A, Wolk A, Kippler M
British journal of cancer 2016;115(9):1113-1121

Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: a double-blind randomized controlled trial
Bouhouch Rr, El-fadeli S, Andersson M, Aboussad A, Chabaa L, Zeder C, et al
The American journal of clinical nutrition 2016;104(5):1318-1326

Elevated childhood exposure to arsenic despite reduced drinking water concentrations--A longitudinal cohort study in rural Bangladesh
Kippler M, Skröder H, Rahman Sm, Tofail F, Vahter M
Environment international 2016;86():119-25

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine
Kippler M, Bottai M, Georgiou V, Koutra K, Chalkiadaki G, Kampouri M, et al
European journal of epidemiology 2016;31(11):1123-1134

Maternal Micronutrient Supplementation and Long Term Health Impact in Children in Rural Bangladesh
Mannan T, Ahmed S, Akhtar E, Roy Ak, Haq Ma, Roy A, et al
PloS one 2016;11(8):e0161294-

Prenatal lead exposure and childhood blood pressure and kidney function
Skröder H, Hawkesworth S, Moore Se, Wagatsuma Y, Kippler M, Vahter M
Environmental research 2016;151():628-634

Alkali dilution of blood samples for high throughput ICP-MS analysis-comparison with acid digestion
Lu Y, Kippler M, Harari F, Grandér M, Palm B, Nordqvist H, et al
Clinical biochemistry 2015;48(3):140-7

Anthroposophic lifestyle influences the concentration of metals in placenta and cord blood
Fagerstedt S, Kippler M, Scheynius A, Gutzeit C, Mie A, Alm J, et al
Environmental research 2015;136():88-96

Kidney function and blood pressure in preschool-aged children exposed to cadmium and arsenic--potential alleviation by selenium
Skröder H, Hawkesworth S, Kippler M, El Arifeen S, Wagatsuma Y, Moore Se, et al
Environmental research 2015;140():205-13

Manganese exposure through drinking water during pregnancy and size at birth: A prospective cohort study
Rahman Sm, Kippler M, Ahmed S, Palm B, El Arifeen S, Vahter M
Reproductive toxicology (Elmsford, N.Y.) 2015;53():68-74

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene
Kuehnelt D, Engström K, Skröder H, Kokarnig S, Schlebusch C, Kippler M, et al
The American journal of clinical nutrition 2015;102(6):1406-15

Selenium status in pregnancy influences children's cognitive function at 1.5 years of age
Skröder Hm, Hamadani Jd, Tofail F, Persson LÅ, Vahter Me, Kippler Mj
Clinical nutrition (Edinburgh, Scotland) 2015;34(5):923-30

Arsenic exposure and cell-mediated immunity in pre-school children in rural Bangladesh
Ahmed S, Moore Se, Kippler M, Gardner R, Hawlader Md, Wagatsuma Y, et al
Toxicological sciences : an official journal of the Society of Toxicology 2014;141(1):166-75

Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes
Rentschler G, Kippler M, Axmon A, Raqib R, Skerfving S, Vahter M, et al
Metallomics : integrated biometal science 2014;6(4):885-91

Dietary exposure to polychlorinated biphenyls is associated with increased risk of stroke in women
Bergkvist C, Kippler M, Larsson Sc, Berglund M, Glynn A, Wolk A, et al
Journal of internal medicine 2014;276(3):248-59

Maternal urinary iodine concentration up to 1.0 mg/L is positively associated with birth weight, length, and head circumference of male offspring
Rydbeck F, Rahman A, Grandér M, Ekström Ec, Vahter M, Kippler M
The Journal of nutrition 2014;144(9):1438-44

Urinary iodine concentrations of pregnant women in rural Bangladesh: a longitudinal study
Rydbeck F, Bottai M, Tofail F, Persson LÅ, Kippler M
Journal of exposure science & environmental epidemiology 2014;24(5):504-9

Early exposure to toxic metals has a limited effect on blood pressure or kidney function in later childhood, rural Bangladesh
Hawkesworth S, Wagatsuma Y, Kippler M, Fulford Aj, Arifeen Se, Persson La, et al
International journal of epidemiology 2013;42(1):176-85

Elevated manganese concentrations in drinking water may be beneficial for fetal survival
Rahman Sm, Akesson A, Kippler M, Grandér M, Hamadani Jd, Streatfield Pk, et al
PloS one 2013;8(9):e74119-

Environmental exposure to metals and children's growth to age 5 years: a prospective cohort study
Gardner Rm, Kippler M, Tofail F, Bottai M, Hamadani J, Grandér M, et al
American journal of epidemiology 2013;177(12):1356-67

Polymorphisms in iron homeostasis genes and urinary cadmium concentrations among nonsmoking women in Argentina and Bangladesh
Rentschler G, Kippler M, Axmon A, Raqib R, Ekström Ec, Skerfving S, et al
Environmental health perspectives 2013;121(4):467-72

Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight
Kippler M, Engström K, Mlakar Sj, Bottai M, Ahmed S, Hossain Mb, et al
Epigenetics 2013;8(5):494-503

Early-life cadmium exposure and child development in 5-year-old girls and boys: a cohort study in rural Bangladesh
Kippler M, Tofail F, Hamadani Jd, Gardner Rm, Grantham-mcgregor Sm, Bottai M, et al
Environmental health perspectives 2012;120(10):1462-8

Early life low-level cadmium exposure is positively associated with increased oxidative stress
Kippler M, Hossain Mb, Lindh C, Moore Se, Kabir I, Vahter M, et al
ENVIRONMENTAL RESEARCH 2012;:164-70

Environmental exposure to arsenic and cadmium during pregnancy and fetal size: a longitudinal study in rural Bangladesh
Kippler M, Wagatsuma Y, Rahman A, Nermell B, Persson LÅ, Raqib R, et al
Reproductive toxicology (Elmsford, N.Y.) 2012;34(4):504-11

In Utero Arsenic Exposure Is Associated With Impaired Thymic Function in Newborns Possibly Via Oxidative Stress and Apoptosis
Ahmed S, Bin Ahsan K, Kippler M, Mily A, Wagatsuma Y, Hoque Amw, et al
TOXICOLOGICAL SCIENCES 2012;129(2):305-14

Maternal Cadmium Exposure during Pregnancy and Size at Birth: A Prospective Cohort Study
Kippler M, Tofail F, Gardner R, Rahman A, Hamadani Jd, Bottai M, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2012;120(2):284-9

Arsenic methylation efficiency increases during the first trimester of pregnancy independent of folate status
Gardner Rm, Nermell B, Kippler M, Grander M, Li L, Ekstrom Ec, et al
REPRODUCTIVE TOXICOLOGY 2011;31(2):210-8

Persistent Exposure to Arsenic via Drinking Water in Rural Bangladesh Despite Major Mitigation Efforts
Gardner R, Hamadani J, Grander M, Tofail F, Nermell B, Palm B, et al
AMERICAN JOURNAL OF PUBLIC HEALTH 2011;:S333-8

Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus
Kippler M, Hoque Amw, Raqib R, Ohrvik H, Ekstrom Ec, Vahter M
TOXICOLOGY LETTERS 2010;192(2):162-8

Assessment of early-life lead exposure in rural Bangladesh
Bergkvist C, Kippler M, Hamadani Jd, Grander M, Tofail F, Berglund M, et al
ENVIRONMENTAL RESEARCH 2010;110(7):718-24

Burden of cadmium in early childhood: Longitudinal assessment of urinary cadmium in rural Bangladesh
Kippler M, Nermell B, Hamadani J, Tofail F, Moore S, Vahter M
TOXICOLOGY LETTERS 2010;198(1):20-5

Chronic exposure to cadmium and arsenic strongly influences concentrations of 8-oxo-7,8-dihydro-2 '-deoxyguanosine in urine
Engstrom Ks, Vahter M, Johansson G, Lindh Ch, Teichert F, Singh R, et al
FREE RADICAL BIOLOGY AND MEDICINE 2010;48(9):1211-7

Cadmium interacts with the transport of essential micronutrients in the mammary gland-A study in rural Bangladeshi women
Kippler M, Lonnerdal B, Goessler W, Ekstrom Ec, El Arifeen S, Vahter M
TOXICOLOGY 2009;257(1-2):64-9

Factors influencing intestinal cadmium uptake in pregnant Bangladeshi women-A prospective cohort study
Kippler M, Goessler W, Nermell B, Ekstrom Ec, Lonnerdal B, El Arifeen S, et al
ENVIRONMENTAL RESEARCH 2009;109(7):914-21

Maternal and Early Life Exposure to Manganese in Rural Bangladesh
Ljung Ks, Kippler Mj, Goessler W, Grander Gm, Nermell Bm, Vahter Me
ENVIRONMENTAL SCIENCE & TECHNOLOGY 2009;43(7):2595-601

Influence of iron and zinc status on cadmium accumulation in Bangladeshi women
Kippler M, Ekstrom Ec, Lonnerdal B, Goessler W, Akesson A, El Arifeen S, et al
TOXICOLOGY AND APPLIED PHARMACOLOGY 2007;222(2):221-6

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