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Education

  • Bachelor of Science (Hons) in Biomedical Sciences, Manchester Metropolitan University, England. Major in Medical Microbiology.
  • Doctor of Philosophy (PhD in Infectious Disease Control (Smittskydd), Department of Microbiology, Tumor and Cell biology, Karolinska Institutet. Title of Thesis: Immunological responses in genital HPV infection and etiology of cervical cancer

Research description

My research is within infectious disease epidemiology and has a main focus on prerequisites for optimal vaccination strategies. As vaccination is one of our most important tools in the combat of infectious disease it is important to maintain public trust. One way of doing this is to evaluate vaccine effectiveness and safety on a population-based level. We have in the past decades reduced the infectious disease burden with vaccination and we are now facing a situation where younger generations who never confronted the actual disease tend to shift their focus toward adverse events instead leading to anti-vaccine movements and misunderstandings about real and perceived risks. Further, with antibiotic resistance we need to develop new vaccines that need to be evaluated on a population-based level.

In addition to this I am also involved in several projects optimizing cervical cancer prevention through both vaccination and screening. In our group we use sophisticated population-based register matching and modelling methods in combination with lab and questionnaire data to evaluate:

1) Short and long term vaccine safety and effectiveness to ensure the reliability of the vaccines;

2) Infectious disease burden to investigate both effectiveness and cost-effectiveness of vaccine programmes;

3) Cervical screening setting and recommendations in a changing reality, as the HPV vaccine and new screening techniques will change the program we have today.

Supervision of doctoral students

Ongoing research projects

Selected publications

Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma.
Herweijer E, Leval A, Ploner A, Eloranta S, Simard J, Dillner J, et al
JAMA 2014 Feb;311(6):597-603

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Links

Publications

No Evidence for Disease History as a Risk Factor for Narcolepsy after A(H1N1)pdm09 Vaccination
Lamb F, Ploner A, Fink K, Maeurer M, Bergman P, Piehl F, et al
PloS one 2016;11(4):e0154296-

Quadrivalent HPV vaccine effectiveness against high-grade cervical lesions by age at vaccination: A population-based study
Herweijer E, Sundstrom K, Ploner A, Uhnoo I, Sparen P, Arnheim-dahlstrom L
International journal of cancer 2016;138(12):2867-74

Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study
Wang J, Andrae B, Sundstrom K, Strom P, Ploner A, Elfstrom Km, et al
BMJ (Clinical research ed.) 2016;352():i276-

A coordinated cross-disciplinary research initiative to address an increased incidence of narcolepsy following the 2009-2010 Pandemrix vaccination programme in Sweden
Feltelius N, Persson I, Ahlqvist-rastad J, Andersson M, Arnheim-dahlstrom L, Bergman P, et al
Journal of internal medicine 2015;278(4):335-53

Cervical cancer screening in Europe: Quality assurance and organisation of programmes
Elfstrom Km, Arnheim-dahlstrom L, Von Karsa L, Dillner J
European journal of cancer (Oxford, England : 1990) 2015;51(8):950-68

Incidence of herpes zoster and associated events including stroke--a population-based cohort study
Sundstrom K, Weibull Ce, Soderberg-lofdal K, Bergstrom T, Sparen P, Arnheim-dahlstrom L
BMC infectious diseases 2015;15():488-

Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases
Ambati A, Poiret T, Svahn Bm, Valentini D, Khademi M, Kockum I, et al
Journal of internal medicine 2015;278(3):264-76

Interactions Between High- and Low-Risk HPV Types Reduce the Risk of Squamous Cervical Cancer
Sundstrom K, Ploner A, Arnheim-dahlstrom L, Eloranta S, Palmgren J, Adami Ho, et al
Journal of the National Cancer Institute 2015;107(10):-

Long-term HPV type-specific risks for ASCUS and LSIL: a 14-year follow-up of a randomized primary HPV screening trial
Elfstrom Km, Smelov V, Johansson Al, Eklund C, Naucler P, Arnheim-dahlstrom L, et al
International journal of cancer 2015;136(2):350-9

Long-term HPV type-specific risks of high-grade cervical intraepithelial lesions: a 14-year follow-up of a randomized primary HPV screening trial
Smelov V, Elfstrom Km, Johansson Al, Eklund C, Naucler P, Arnheim-dahlstrom L, et al
International journal of cancer 2015;136(5):1171-80

Organization and quality of HPV vaccination programs in Europe
Elfstrom Km, Dillner J, Arnheim-dahlstrom L
Vaccine 2015;33(14):1673-81

Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system
Scheller Nm, Svanstrom H, Pasternak B, Arnheim-dahlstrom L, Sundstrom K, Fink K, et al
JAMA 2015;313(1):54-61

The Participation of HPV-Vaccinated Women in a National Cervical Screening Program: Population-Based Cohort Study
Herweijer E, Feldman Al, Ploner A, Arnheim-dahlstrom L, Uhnoo I, Netterlid E, et al
PloS one 2015;10(7):e0134185-

A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010
Lind A, Ramelius A, Olsson T, Arnheim-dahlstrom L, Lamb F, Khademi M, et al
Journal of autoimmunity 2014;50():99-106

Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma
Herweijer E, Leval A, Ploner A, Eloranta S, Simard Jf, Dillner J, et al
JAMA 2014;311(6):597-603

Current cervical cancer prevention strategies including cervical screening and prophylactic human papillomavirus vaccination: a review
Elfstrom Km, Herweijer E, Sundstrom K, Arnheim-dahlstrom L
Current opinion in oncology 2014;26(1):120-9

Guillain-Barré syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccines: a multinational self-controlled case series in Europe
Romio S, Weibel D, Dieleman Jp, Olberg Hk, De Vries Cs, Sammon C, et al
PloS one 2014;9(1):e82222-

Human papillomavirus (HPV) vaccination and subsequent sexual behaviour: evidence from a large survey of Nordic women
Hansen Bt, Kjaer Sk, Arnheim-dahlstrom L, Liaw Kl, Jensen Ke, Thomsen Lt, et al
Vaccine 2014;32(39):4945-53

Long term duration of protective effect for HPV negative women: follow-up of primary HPV screening randomised controlled trial
Elfstrom Km, Smelov V, Johansson Al, Eklund C, Naucler P, Arnheim-dahlstrom L, et al
BMJ (Clinical research ed.) 2014;348():g130-

Number of human papillomavirus vaccine doses and condyloma--reply
Ploner A, Herweijer E, Arnheim-dahlstrom L
JAMA 2014;311(23):2439-40

Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study
Arnheim-dahlstrom L, Pasternak B, Svanstrom H, Sparen P, Hviid A
BMJ (Clinical research ed.) 2013;347():f5906-

International collaboration to assess the risk of Guillain Barré Syndrome following Influenza A (H1N1) 2009 monovalent vaccines
Dodd Cn, Romio Sa, Black S, Vellozzi C, Andrews N, Sturkenboom M, et al
Vaccine 2013;31(40):4448-58

Prospective study of HPV16 viral load and risk of in situ and invasive squamous cervical cancer
Sundstrom K, Ploner A, Dahlstrom La, Palmgren J, Dillner J, Adami Ho, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013;22(1):150-8

Quadrivalent human papillomavirus vaccine effectiveness: a Swedish national cohort study
Leval A, Herweijer E, Ploner A, Eloranta S, Fridman Simard J, Dillner J, et al
Journal of the National Cancer Institute 2013;105(7):469-74

The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
Wijnans L, Lecomte C, De Vries C, Weibel D, Sammon C, Hviid A, et al
Vaccine 2013;31(8):1246-54

A collaborative approach to investigating the risk of thrombocytopenic purpura after measles-mumps-rubella vaccination in England and Denmark
Andrews N, Stowe J, Miller E, Svanstrom H, Johansen K, Bonhoeffer J, et al
Vaccine 2012;30(19):3042-6

Awareness and knowledge of human papillomavirus in the Swedish adult population
Dahlstrom La, Sundstrom K, Young C, Lundholm C, Sparen P, Tran Tn
The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2012;50(2):204-6

Guillain-Barre Syndrome and Adjuvanted Pandemic Influenza A (H1N1) 2009 Vaccine: Multinational Self Controlled Case Series Study in Europe
Weibel D, Romio S, Dieleman Jp, De Vries Cs, Sammon C, Andrews N, et al
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 2012;:354-355

Incidence of genital warts in Sweden before and after quadrivalent human papillomavirus vaccine availability
Leval A, Herweijer E, Arnheim-dahlstrom L, Walum H, Frans E, Sparen P, et al
The Journal of infectious diseases 2012;206(6):860-6

Risk of presentation to hospital with epileptic seizures after vaccination with monovalent AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine (Pandemrix): self controlled case series study
Arnheim-dahlstrom L, Hallgren J, Weibull Ce, Sparen P
BMJ (Clinical research ed.) 2012;345():e7594-

Assessing perceived risk and STI prevention behavior: a national population-based study with special reference to HPV
Leval A, Sundstrom K, Ploner A, Dahlstrom La, Widmark C, Sparen P
PloS one 2011;6(6):e20624-

Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe
Dieleman J, Romio S, Johansen K, Weibel D, Bonhoeffer J, Sturkenboom M, et al
BMJ (Clinical research ed.) 2011;343():d3908-

Prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer
Arnheim Dahlstrom L, Andersson K, Luostarinen T, Thoresen S, Ogmundsdottir H, Tryggvadottir L, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(12):2541-50

Safety of Adjuvanted Pandemic Influenza Vaccines: Background Rate of Narcolepsy in Europe
Dieleman J, Lecomte C, Schuemie M, Van Rolleghem A, Hviid A, Svanstrom H, et al
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 2011;:S260-S260

Acceptability of HPV vaccination among young adults aged 18-30 years--a population based survey in Sweden
Sundstrom K, Tran Tn, Lundholm C, Young C, Sparen P, Dahlstrom La
Vaccine 2010;28(47):7492-500

Attitudes to HPV vaccination among parents of children aged 12-15 years-a population-based survey in Sweden
Dahlstrom La, Tran Tn, Lundholm C, Young C, Sundstrom K, Sparen P
International journal of cancer 2010;126(2):500-7

Prospective study of human papillomavirus and risk of cervical adenocarcinoma
Dahlstrom La, Ylitalo N, Sundstrom K, Palmgren J, Ploner A, Eloranta S, et al
International journal of cancer 2010;127(8):1923-30

Prospective study of human papillomavirus (HPV) types, HPV persistence, and risk of squamous cell carcinoma of the cervix
Sundstrom K, Eloranta S, Sparen P, Arnheim Dahlstrom L, Gunnell A, Lindgren A, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(10):2469-78

A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia
Arnheim L, Dillner J, Sanjeevi Cb
Tissue antigens 2005;65(3):252-9

Chlamydia trachomatis infection and persistence of human papillomavirus
Silins I, Ryd W, Strand A, Wadell G, Tornberg S, Hansson Bg, et al
International journal of cancer 2005;116(1):110-5

HPV-16 L1 genes with inactivated negative RNA elements induce potent immune responses
Rollman E, Arnheim L, Collier B, Oberg D, Hall H, Klingstrom J, et al
Virology 2004;322(1):182-9

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