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Juan-Jesus Carrero-Roig

Senior researcher

About me

Juan Jesus Carrero serves as Senior Researcher in Renal Epidemiology at the Division of Renal Medicine (CLINTEC) and Center for Molecular Medicine (MMK), both at Karolinska Institutet (KI). His professional ambition is to raise awareness of kidney dysfunction and its consequences, and to integrate kidney dysfunction management in all facets of healthcare.

Since his arrival at KI, he have authored more than 200 articles as well as 15 book chapters on metabolic risk factors for chronic kidney disease, with special emphasis on the areas of inflammation, malnutrition, and endocrine disorders. His work has received over 4500 citations and his H index is currently 41 according to GoogleScholar. 

Dr. Carrero sits in the council of the International Society of Renal Nutrition and Metabolism (ISRNM), founder and secretary of the European Renal Nutrition working group at the ERA-EDTA and is a visiting professor at Federal University of Rio de Janeiro (Brazil). He serves as Associate Editor for Nephrology Dialysis and Transplantantation and is an editorial board member for various journals including Journal of Renal Nutrition, Journal of Nephrology, and Nephrol Dial and Transplant-Educational (NDT-e). 

Since 2008 organizes the Advanced Renal Nutrition International Conference at KI, where more than 100 healthcare professionals gather annually to discuss advances in renal nutrition research and management. In addition, Dr. Carrero is a frequent invited lecturer to national and international scientific conferences worldwide.

 

Education

2013 Associate Professor (Docent) in Renal Medicine

2008, PhD in Medicine, Karolinska Institutet, Sweden

2005, PhD in Pharmacy, University of Granada, Spain

2002, Master in Business and Administration, University of Granada, Spain

2000, Bachelor in Pharmacy, University of Granada, Spain

Research description

Innovative medical research is achieved when existing information is used in novel ways to improve healthcare, or when unknown or unnoticed patient aspects of disease are integrated into therapeutic management. My long term goal is to improve in patient care by integrating kidney function aspects in disease management.

We have established a successful National and International consortium and repository of registers addressing healthcare implications of kidney dysfunction and identification of modifiable risk factors to retard kidney disease progression. These include, among others:

 

In addition, we created a unique patient cohort: the Stockholm CREAtinine Measurement (SCREAM) project. SCREAM is a patient laboratory-database merged with National and Regional Health Care Registers. This has been made possible by agreements with the main laboratory service providers of Stockholm (Unilabs, Karolinska and Aleris), which together run the vast majority of laboratory analyses of the County.

 

Included are all individuals residing in Stockholm County that underwent at least one measurement of creatinine or cystatin-C assessed in either primary, in- or out-patient care during 2006-2011. Sample size surpasses 1.3 million people. Together with kidney function estimates, concurrent basic laboratory biochemistry is also available. Patient data has been, in addition, linked to National Health Care Registers including the Swedish Medication Register (Lakemedelsregister), the Inpatient Register, the Death Register, the Socioeconomic Register (Statistiska centralbyrån, SCB), and the Swedish Renal Register.

 

SCREAM is coupled with a practical implementation program within Stockholm Healthcare (Stockholm Läns Landsting, SLL) aimed at raising awareness among prescribers of the importance of kidney dysfunction and drug interactions.

 

Our main working hypotheses are:

  • Community kidney dysfunction is common, but seldom screened and thus taken into account in patient care.
  • Our understanding of risk factors for and healthcare implications of kidney dysfunction is suboptimal, which limits the implementation of preventive/management strategies.
  • The kidney is fundamental for drug metabolism/elimination. Because of low awareness of kidney disease, inappropriate drug prescription is likely to occur.
  • The safety and effectiveness of many drugs are unknown in individuals with manifest chronic kidney disease, as these individuals are usually excluded from clinical trials.

 

We welcome research collaborations. Please, do contact us if you share our fascination for renal epidemiology research

 

Selected publications from 2015 and 2014

Huang X, Sui X, Ruiz JR, Hirth V, Ortega FB, Blair SN, Carrero JJ. Parental History of Premature Cardiovascular Disease, Estimated GFR, and Rate of Estimated GFR Decline: Results From the Aerobics Center Longitudinal Study. Am J Kidney Dis. 2015 Jan 16. pii: S0272-6386(14)01531-5. doi: 10.1053/j.ajkd.2014.11.021. [Epub ahead of print].

Cordeiro AC, Amparo FC, Oliveira MAC, Amodeo C, Smanio P, Pinto IMF, Lindholm B, Stenvinkel P, Carrero JJ. Epicardial fat accumulation, cardiometabolic profile and cardiovascular events in patients with chronic kidney disease stage 3-5. J Intern Med. 2015 Jan 5. doi: 10.1111/joim.12344. [Epub ahead of print]

Xu H, Sjögren P, Ärnlöv J, Banerjee T, Cederholm T, Risérus U, Lindholm B, Lind L, Carrero JJ. A pro-inflammatory diet is associated with systemic inflammation and reduced kidney function in elderly adults. J Nutr. 2015 April; 145: 729-35.

Szummer K, Oldgren O, Lindhagen L, Carrero JJ, Evans M, Spaak J, Edfors R, Jacobson SH, Andell P, Wallentin L, Jernberg T. Association between the use of Fondaparinux versus Low Molecular Weight Heparin and Clinical Outcomes in Patients with non-ST-elevation Myocardial Infarction in a Swedish Register. JAMA. 2015 Feb 17;313(7):707-16.

Jia T, Riserus U, Xu H, Lindholm B, Arnlöv J, Sjögren P, Cederholm T, Larsson TE, Ikizler TA, Carrero JJ. Kidney function, β cell function and glucose tolerance in older men. J Clin Endocrinol Metab. 2015 Feb;100(2):587-593.

Jia T, Byberg L, Lindholm B, Larsson TE, Lind L, Michaëlsson K, Carrero JJ. Dietary acid load, kidney function, osteoporosis and risk of fractures in elderly men and women. Osteoporos Int. 2015 Feb;26(2):563-70.

Luis DS, Huang X, Riserus U, Sjögren P, Lindholm B, Arnlöv J, Cederholm T, Carrero JJ. Dietary acid, kidney function, changes in blood pressure and hypertension incidence in community-dwelling elderly men. J Nutr. 2015 Feb;145(2):315-21.

Xu H, Huang X, Risérus U, Krishnamurthy VMR, Cederholm T, Ärnlöv J, Lindholm B, Sjogren P, Carrero JJ. Dietary fiber, kidney function and risk of mortality. Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2104-10.

Isoyama N, Qureshi AR, Avesani CM, Lindholm B, Bàràny P, Heimbürger O, Cederholm T, Stenvinkel P and Carrero JJ. Comparative associations of muscle mass and muscle strength with mortality in dialysis patients. Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1720-8.

Xu H, Jia T, Huang X, Risérus U, Cederholm T, Ärnlöv J, Sjogren P, Lindholm B, Carrero JJ. Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men. Diabetologia. 2014 Aug;57(8):1561-8.

Jia T, Huang X, Xu H, Arnlöv J, Lindholm B, Cederlholm T, Stenvinkel P, Risérus U, Carrero JJ. Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function. Kidney Int. 2014 Aug;86(2):383-91.

Carrero JJ, Evans M, Szummer K, Spaak J, Lindhagen L, Edfors R, Stenvinkel P, Jacobson S, Jernberg T. Warfarin treatment, kidney dysfunction and outcomes in acute myocardial infarction patients with atrial fibrillation. JAMA. March 2014; 311(9):913-915.

Xu H, Huang X, Arnlöv J, Cederholm T, Stenvinkel P, Lindholm B, Risérus U, Carrero JJ. Clinical determinants and mortality predictability of insulin sensitivity in men with chronic kidney disease stages 3-4. Clin J Am Soc Nephrol. 2014 Apr;9(4):690-697.

Huang X, Sjögren P, Arnlöv J, Cederholm T, Lind L, Stenvinkel P, Lindholm B, Risérus U, Carrero JJ. Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease. J Intern Med. 2014 Jan;275(1):71-83.

 

Academic honors, awards and prizes

2014, Italian Society of Nephrology, Journal of Nutrition (JN) award for most cited article during 2013

2014, US National Kidney Foundation “Joel D. Kopple” award for contributions to Renal Nutrition Research

2012, Awarded recognition for scientific achievements at "VIII International Conference on Hypertension and the Kidney". Madrid, Spain

Award for young researchers at Karolinska Institutet funds in 2013, 2011 and 2008

Research grant for best research project by young investigators (ESPEN, European Society for Parenteral and Enteral Nutrition, 2006)

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