Center for infectious Medicine
Department of Medicine, Huddinge (MedH), H7
Professor of Viral Immunology at the Department of Medicine, Huddinge since 2013.
Innate and adaptive immune mechanisms work together to contain viral infections including human immunodeficiency virus 1 (HIV-1) and hepatitis C virus (HCV). We investigate basic aspects of cell-mediated immunity as well as the immunopathogenesis of these infections. We do this with a basis in our solid understanding of fundamental immunology that we apply towards patient-based research and develop into translational approaches. The majority of T lymphocytes carry diverse T cell receptors (TCRs) that display classical MHC-restriction. However, the T cell compartment also includes invariant T cell subsets that recognize antigens presented by non-classical MHC-like molecules. Several of these invariant T cell subsets are evolutionarily conserved, display innate-like characteristics, and play important roles in immune control of pathogens. The group is particularly interested in the role of adaptive T cell responses mediated by CD8 T cells, and in the role that innate-like T cells such as the invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells play in host defense.
Selected recent publications:
Leeansyah, E., Ganesh, A., Quigley, M. F., Sönnerborg, A., Andersson, J., Hunt, P. W., Somsouk, M., Deeks, S. G., Martin, J. N., Moll, M., Shacklett, B. L. and Sandberg, J. K. (2013) Activation, exhaustion and persistent decline of the anti-microbial MR1-restricted MAIT cell population in chronic HIV-1 infection. Blood. 121: 1124-1135.
Blom, K., Braun, M., Ivarsson, M., Gonzalez, V. D., Falconer, K., Moll, M., Ljunggren, H. G., Michaelsson, J. and Sandberg, J. K. (2013) Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. J. Immunol. 190: 2150-2158.
Leeansyah, E., Loh, L., Nixon, D. F. and Sandberg, J. K. (2014) Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT cell development. Nature Communications. 5:3143. doi: 10.1038/ncomms4143.