Professor of Viral Immunology at the Department of Medicine, Huddinge since 2013.
Innate and adaptive immune mechanisms work together to contain viral infections including human immunodeficiency virus 1 (HIV-1) and hepatitis C virus (HCV). We investigate basic aspects of cell-mediated immunity as well as the immunopathogenesis of these infections. We do this with a basis in our solid understanding of fundamental immunology that we apply towards patient-based research and develop into translational approaches. The majority of T lymphocytes carry diverse T cell receptors (TCRs) that display classical MHC-restriction. However, the T cell compartment also includes invariant T cell subsets that recognize antigens presented by non-classical MHC-like molecules. Several of these invariant T cell subsets are evolutionarily conserved, display innate-like characteristics, and play important roles in immune control of pathogens. The group is particularly interested in the role of adaptive T cell responses mediated by CD8 T cells, and in the role that innate-like T cells such as the invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells play in host defense.
Selected recent publications:
Leeansyah, E., Ganesh, A., Quigley, M. F., Sönnerborg, A., Andersson, J., Hunt, P. W., Somsouk, M., Deeks, S. G., Martin, J. N., Moll, M., Shacklett, B. L. and Sandberg, J. K. (2013) Activation, exhaustion and persistent decline of the anti-microbial MR1-restricted MAIT cell population in chronic HIV-1 infection. Blood. 121: 1124-1135.
Blom, K., Braun, M., Ivarsson, M., Gonzalez, V. D., Falconer, K., Moll, M., Ljunggren, H. G., Michaelsson, J. and Sandberg, J. K. (2013) Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. J. Immunol. 190: 2150-2158.
Leeansyah, E., Loh, L., Nixon, D. F. and Sandberg, J. K. (2014) Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT cell development. Nature Communications. 5:3143. doi: 10.1038/ncomms4143.