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Education

  • 2003 Master of Science in Engineering Biology, Umeå University, Umeå.
  • 2008 PhD in Biotechnology, Royal Institute of Technology, Stockholm.
  • 2009-2013 Postdoc, Karolinska Institutet, Stockholm.
  • 2013-2017 Assistant Professor, Karolinska Institutet, Stockholm.

Research description

I am heading the Cancer Genomics team at MEB.  The team consists currently of two bioinformaticians, three research engineers and one postdoc. The team has a translational focus, with the goal to pursue clinically relevant research questions. We have developed an informatics infrastructure consisting of in-house developed- and publically available tools to enable live processing of sequencing based data. 

The Cancer Genomics team is responsible for targeted sequencing in a prospective clinical trial investigating the effect of adjuvant aspirin treatment of PI3K mutated localized colorectal cancer. Patient inclusion was initiated in the fall 2016 and during the first year 542 colorectal cancers were profiled with two weeks turnover. Reports with randomization information is being sent on a weekly basis to a national network of 27 participating hospitals. The trial will run until approximately 4000 study participants have been included.

We are conducting large studies in prostate cancer where genomic profiling is used to address tumor grading, prognostication at diagnosis and optimization of treatment in the metastatic setting. 

We have developed a targeted circulating tumour DNA-based profile that enables us to detect:

  • Mutations, amplifications and genomic rearrangements in the androgen receptor.
  • Mutations, genomic rearrangements and amplifications/deletions in key genes involved in prostate cancer.
  • DNA-repair deficiency.
  • Microsatellite instable and hypermutated cancers.

We are currently preparing to enable live profiling of circulating tumor DNA in metastatic prostate cancer in a clinical trial setting.  The goal is to initiate the clinical trial (ProBio-II) before April 1st, 2018. 

The Cancer Genomics team is part of a larger research environment with 20-25 persons focused on different aspects of prostate cancer, which is lead by Henrik Grönberg.

 

Teaching portfolio

I am teaching whenever I get the chance. I am currently co-responsible for the course "Biobanking as a resource for biomedical research".

 

 

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