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About me

Håkan Westerblad is Professor of Cellular Muscle Physiology at the Department of Physiology and Pharmacology since 2003.

Research description

The original focus of my research group is cellular mechanisms of skeletal muscle fatigue. We also study mechanisms behind muscle adaptations in response to training and maladaptations in disease, e.g. mitochondrial myopathies. To a large extent our research relates to the complex interactions between force production, intracellular calcium handling, mitochondrial function and reactive oxygen/nitrogen species.

Our experiments are performed on adult muscle, including unique methods to study isolated fully intact muscle fibers. We find this essential because the functions we are studying differ markedly between adult muscle and immature muscle cells/muscle-like cell lines.

Links

Publications

Dietary nitrate markedly improves voluntary running in mice
Ivarsson N, Schiffer Ta, Hernández A, Lanner Jt, Weitzberg E, Lundberg Jo, et al
Physiology & behavior 2017;168():55-61

Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular Ca Handling
Cheng Aj, Place N, Westerblad H
Cold Spring Harbor perspectives in medicine 2017;():-

Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat
Himori K, Tatebayashi D, Kanzaki K, Wada M, Westerblad H, Lanner Jt, et al
PloS one 2017;12(6):e0179925-

Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension
Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner Jt, et al
PloS one 2017;12(2):e0169146-

The Ca sensitizer CK-2066260 increases myofibrillar Ca sensitivity and submaximal force selectively in fast skeletal muscle
Hwee Dt, Cheng Aj, Hartman Jj, Hinken Ac, Lee K, Durham N, et al
The Journal of physiology 2017;595(5):1657-1670

A numerical model for fatigue effects in whole-body human exercise
Eriksson A, Holmberg Hc, Westerblad H
MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS 2016;22(1):21-38

Dietary nitrate improves cardiac contractility via enhanced cellular Ca²⁺ signaling
Pironti G, Ivarsson N, Yang J, Farinotti Ab, Jonsson W, Zhang Sj, et al
Basic research in cardiology 2016;111(3):34-

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Schlittler M, Goiny M, Agudelo Lz, Venckunas T, Brazaitis M, Skurvydas A, et al
American journal of physiology. Cell physiology 2016;310(10):C836-40

Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy
Llano-diez M, Cheng Aj, Jonsson W, Ivarsson N, Westerblad H, Sun V, et al
Critical care (London, England) 2016;20(1):254-

Mechanisms of force depression caused by different types of physical exercise studied by direct electrical stimulation of human quadriceps muscle
Skurvydas A, Mamkus G, Kamandulis S, Dudoniene V, Valanciene D, Westerblad H
European journal of applied physiology 2016;116(11-12):2215-2224

Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles
Neyroud D, Cheng Aj, Bourdillon N, Kayser B, Place N, Westerblad H
Frontiers in physiology 2016;7():252-

Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery
Cheng Aj, Yamada T, Rassier De, Andersson Dc, Westerblad H, Lanner Jt
The Journal of physiology 2016;594(18):5149-60

The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome
Llano-diez M, Sinclair J, Yamada T, Zong M, Fauconnier J, Zhang Sj, et al
PloS one 2016;11(12):e0167090-

Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres
Cheng Aj, Bruton Jd, Lanner Jt, Westerblad H
The Journal of physiology 2015;593(2):457-72

An updated h-index measures both the primary and total scientific output of a researcher
Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson Gl, Sumazin P, et al
Discoveries (Craiova, Romania) 2015;3(3):-

Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy
Gineste C, Hernandez A, Ivarsson N, Cheng Aj, Naess K, Wibom R, et al
Human molecular genetics 2015;24(23):6580-7

Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes
Olsson K, Cheng Aj, Alam S, Al-ameri M, Rullman E, Westerblad H, et al
Skeletal muscle 2015;5():26-

Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment
Yamada T, Abe M, Lee J, Tatebayashi D, Himori K, Kanzaki K, et al
Skeletal muscle 2015;5():20-

Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness
Yamada T, Fedotovskaya O, Cheng Aj, Cornachione As, Minozzo Fc, Aulin C, et al
Annals of the rheumatic diseases 2015;74(10):1907-14

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise
Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng Aj, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(50):15492-7

Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres
Cheng Aj, Bruton Jd, Lanner Jt, Westerblad H
The Journal of physiology 2014;():-

Effects of N-acetylcysteine on isolated mouse skeletal muscle: contractile properties, temperature dependence, and metabolism
Katz A, Hernández A, Caballero Dm, Briceno Jf, Amezquita Lv, Kosterina N, et al
Pflugers Archiv : European journal of physiology 2014;466(3):577-85

Regulation of glycogen breakdown and its consequences for skeletal muscle function after training
Katz A, Westerblad H
MAMMALIAN GENOME 2014;25(9-10):464-72

Subcellular distribution of glycogen and decreased tetanic Ca2+ in fatigued single intact mouse muscle fibres
Nielsen J, Cheng Aj, Ortenblad N, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2014;592(9):2003-12

TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes
Roberge S, Roussel J, Andersson Dc, Meli Ac, Vidal B, Blandel F, et al
Cardiovascular research 2014;103(1):90-9

Usage of a localised microflow device to show that mitochondrial networks are not extensive in skeletal muscle fibres
Bruton J, Jeffries Gd, Westerblad H
PloS one 2014;9(9):e108601-

Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres
Cheng Aj, Place N, Bruton Jd, Holmberg Hc, Westerblad H
The Journal of physiology 2013;591(15):3739-48

Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis
Munters La, Dastmalchi M, Katz A, Esbjornsson M, Loell I, Hanna B, et al
ARTHRITIS RESEARCH & THERAPY 2013;15(4):R83-

Muscle glycogen stores and fatigue
Ortenblad N, Westerblad H, Nielsen J
JOURNAL OF PHYSIOLOGY-LONDON 2013;591(18):4405-13

Residual force depression following muscle shortening is exaggerated by prior eccentric drop jump exercise
Dargeviciute G, Masiulis N, Kamandulis S, Skurvydas A, Westerblad H
JOURNAL OF APPLIED PHYSIOLOGY 2013;115(8):1191-5

TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
Zong M, Bruton Jd, Grundtman C, Yang H, Li Jh, Alexanderson H, et al
Annals of the rheumatic diseases 2013;72(8):1390-9

Antioxidants and Skeletal Muscle Performance: "Common Knowledge" vs. Experimental Evidence
Hernández A, Cheng A, Westerblad H
Frontiers in physiology 2012;3():46-

Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle
Hernández A, Schiffer Ta, Ivarsson N, Cheng Aj, Bruton Jd, Lundberg Jo, et al
The Journal of physiology 2012;590(15):3575-83

History effect and timing of force production introduced in a skeletal muscle model
Kosterina N, Westerblad H, Eriksson A
Biomechanics and modeling in mechanobiology 2012;11(7):947-57

Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice
Yamada T, Ivarsson N, Hernández A, Fahlström A, Cheng Aj, Zhang Sj, et al
The Journal of physiology 2012;590(23):6187-97

Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production
Gonon At, Jung C, Katz A, Westerblad H, Shemyakin A, Sjöquist Po, et al
PloS one 2012;7(7):e42038-

Methods to detect Ca(2+) in living cells
Bruton Jd, Cheng Aj, Westerblad H
Advances in experimental medicine and biology 2012;740():27-43

Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle
Lamb Gd, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2011;589(9):2119-27

Emerging Roles of ROS/RNS in Muscle Function and Fatigue
Westerblad H, Allen Dg
ANTIOXIDANTS & REDOX SIGNALING 2011;15(9):2487-99

Enhanced Cardiomyocyte Ca2+ Cycling Precedes Terminal AV-Block in Mitochondrial Cardiomyopathy Mterf3 KO Mice
Andersson Dc, Fauconnier J, Park Cb, Zhang Sj, Thireau J, Ivarsson N, et al
ANTIOXIDANTS & REDOX SIGNALING 2011;15(9):2455-64

Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes
Andersson Dc, Fauconnier J, Yamada T, Lacampagne A, Zhang Sj, Katz A, et al
JOURNAL OF PHYSIOLOGY-LONDON 2011;589(7):1791-801

The role of in vivo Ca2+ signals acting on Ca2+-calmodulin-dependent proteins for skeletal muscle plasticity
Tavi P, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2011;589(21):5021-31

2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle
Zhang Sj, Sandstrom M, Ahlsen M, Ivarsson N, Zhu H, Ma Jj, et al
EXPERIMENTAL PHYSIOLOGY 2010;95(8):892-8

beta-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle
Yamada T, Zhang Sj, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2010;299(3):E364-73

Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
Grundtman C, Bruton J, Yamada T, Ostberg T, Pisetsky Ds, Harris He, et al
FASEB JOURNAL 2010;24(2):570-8

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice
Bruton Jd, Aydin J, Yamada T, Shabalina Ig, Ivarsson N, Zhang Sj, et al
JOURNAL OF PHYSIOLOGY-LONDON 2010;588(21):4275-88

Mechanisms of Skeletal Muscle Weakness
Westerblad H, Place N, Yamada T
MUSCLE BIOPHYSICS: FROM MOLECULES TO CELLS 2010;:279-96

Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
Place N, Yamada T, Bruton Jd, Westerblad H
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2010;110(1):1-15

Myogenic Skeletal Muscle Satellite Cells Communicate by Tunnelling Nanotubes
Tavi P, Korhonen T, Hanninen Sl, Bruton Jd, Loof S, Simon A, et al
JOURNAL OF CELLULAR PHYSIOLOGY 2010;223(2):376-83

Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability
Westerblad H, Bruton Jd, Katz A
EXPERIMENTAL CELL RESEARCH 2010;316(18):3093-9

The decrease in electrically evoked force production is delayed by a previous bout of stretch-shortening cycle exercise
Kamandulis S, Skurvydas A, Masiulis N, Mamkus G, Westerblad H
ACTA PHYSIOLOGICA 2010;198(1):91-8

Thyroid hormone receptor alpha can control action potential duration in mouse ventricular myocytes through the KCNE1 ion channel subunit
Mansen A, Tiselius C, Sand P, Fauconnier J, Westerblad H, Rydqvist B, et al
ACTA PHYSIOLOGICA 2010;198(2):133-42

What limits exercise during high-intensity aerobic exercise?
Allen D, Westerblad H
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2010;110(3):661-2

Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
Gilliam Laa, Ferreira Lf, Bruton Jd, Moylan Js, Westerblad H, Clair Dks, et al
JOURNAL OF APPLIED PHYSIOLOGY 2009;107(6):1935-42

High temperature does not alter fatigability in intact mouse skeletal muscle fibres
Place N, Yamada T, Zhang Sj, Westerblad H, Bruton Jd
JOURNAL OF PHYSIOLOGY-LONDON 2009;587(19):4717-24

Impaired Myofibrillar Function in the Soleus Muscle of Mice With Collagen-Induced Arthritis
Yamada T, Place N, Kosterina N, Ostberg T, Zhang Sj, Grundtman C, et al
ARTHRITIS AND RHEUMATISM 2009;60(11):3280-9

Increased mitochondrial Ca2+ and decreased sarcoplasmic reticulum Ca2+ in mitochondrial myopathy
Aydin J, Andersson Dc, Hanninen Sl, Wredenberg A, Tavi P, Park Cb, et al
HUMAN MOLECULAR GENETICS 2009;18(2):278-88

Knockdown of TRPC3 with siRNA coupled to carbon nanotubes results in decreased insulin-mediated glucose uptake in adult skeletal muscle cells
Lanner Jt, Bruton Jd, Assefaw-redda Y, Andronache Z, Zhang Sj, Severa D, et al
FASEB JOURNAL 2009;23(6):1728-38

Mechanical work as predictor of force enhancement and force depression
Kosterina N, Westerblad H, Eriksson A
JOURNAL OF BIOMECHANICS 2009;42(11):1628-34

MECHANISMS OF FATIGUE INDUCED BY ISOMETRIC CONTRACTIONS IN EXERCISING HUMANS AND IN MOUSE ISOLATED SINGLE MUSCLE FIBRES
Place N, Bruton Jd, Westerblad H
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 2009;36(3):334-9

UPREGULATION OF MHC CLASS I IN TRANSGENIC MICE RESULTS IN REDUCED FORCE-GENERATING CAPACITY IN SLOW-TWITCH MUSCLE
Salomonsson S, Grundtman C, Zhang Sj, Lanner Jt, Li C, Katz A, et al
MUSCLE & NERVE 2009;39(5):674-82

Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice
Zhang Sj, Sandstrom Me, Aydin J, Westerblad H, Wieringa B, Katz A
ACTA PHYSIOLOGICA 2008;192(3):413-20

Ca2+ and insulin-mediated glucose uptake
Lanner Jt, Bruton Jd, Katz A, Westerblad H
CURRENT OPINION IN PHARMACOLOGY 2008;8(3):339-45

Impaired calcium release during fatigue
Allen Dg, Lamb Gd, Westerblad H
JOURNAL OF APPLIED PHYSIOLOGY 2008;104(1):296-305

Interpolated twitches in fatiguing single mouse muscle fibres: implications for the assessment of central fatigue
Place N, Yamada T, Bruton Jd, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2008;586(11):2799-805

Locomotor deficiencies and aberrant development of subtype-specific GABAergic Interneurons caused by an unliganded thyroid hormone receptor alpha 1
Wallis K, Sjogren M, Van Hogerlinden M, Silberberg G, Fisahn A, Nordstrom K, et al
JOURNAL OF NEUROSCIENCE 2008;28(8):1904-15

Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria
Kostareva A, Sjoberg G, Bruton J, Zhang Sj, Balogh J, Gudkova A, et al
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 2008;29(1):25-36

Muscular force production after concentric contraction
Kosterina N, Westerblad H, Lannergren J, Eriksson A
JOURNAL OF BIOMECHANICS 2008;41(11):2422-9

Nonshivering thermogenesis protects against defective calcium handling in muscle
Aydin J, Shabalina Ig, Place N, Reiken S, Zhang Sj, Bellinger Am, et al
FASEB JOURNAL 2008;22(11):3919-24

Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice
Bruton Jd, Place N, Yamada T, Silva Jp, Andrade Fh, Dahlstedt Aj, et al
JOURNAL OF PHYSIOLOGY-LONDON 2008;586(1):175-84

Skeletal muscle fatigue: Cellular mechanisms
Allen Dg, Lamb Gd, Westerblad H
PHYSIOLOGICAL REVIEWS 2008;88(1):287-332

A(1) receptor deficiency causes increased insulin and glucagon secretion in mice
Johansson Sm, Salehi A, Sandstrom Me, Westerblad H, Lundquist I, Carlsson Po, et al
BIOCHEMICAL PHARMACOLOGY 2007;74(11):1628-35

Activation of aconitase in mouse fast-twitch skeletal muscle during contraction-mediated oxidative stress
Zhang Sj, Sandstrom Me, Lanner Jt, Thorell A, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007;293(3):C1154-9

Activation of Ca2+-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca2+ release
Aydin J, Korhonen T, Tavi P, Allen Dg, Westerblad H, Bruton Jd
ACTA PHYSIOLOGICA 2007;191(2):131-7

Can activation account for 80% of skeletal muscle energy use during isometric contraction? Reply to Barclay and Loiselle
Zhang Sj, Andersson Dc, Sandstrom Me, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007;292(1):C613-C614

Effects of palmitate on Ca2+ handling in adult control and ob/ob cardiomyocytes
Fauconnier J, Andersson Dc, Zhang Sj, Lanner Jt, Wibom R, Katz A, et al
DIABETES 2007;56(4):1136-42

Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor a1
Sjogren M, Alkemade A, Mittag J, Nordstrom K, Katz A, Rozell B, et al
EMBO JOURNAL 2007;26(21):4535-45

Insulin potentiates TRPC3-mediated cation currents in normal but not in insulin-resistant mouse cardiomyocytes
Fauconnier J, Lanner Jt, Sultan A, Zhang Sj, Katz A, Bruton Jd, et al
CARDIOVASCULAR RESEARCH 2007;73(2):376-85

Mechanical load plays little role in contraction-mediated glucose transport in mouse skeletal muscle
Sandstrom Me, Zhang Sj, Westerblad H, Katz A
JOURNAL OF PHYSIOLOGY-LONDON 2007;579(2):527-34

Cross bridges account for only 20% of total ATP consumption during submaximal isometric contraction in mouse fast-twitch skeletal muscle
Zhang Sj, Andersson Dc, Sandstrom Me, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2006;291(1):C147-54

Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Lunde Pk, Sejersted Om, Thorud Hms, Tonnessen T, Henriksen Ul, Christensen G, et al
CIRCULATION RESEARCH 2006;98(12):1514-9

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
Wredenberg A, Freyer C, Sandstrom Me, Katz A, Wibom R, Westerblad H, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006;350(1):202-7

Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle
Sandstrom Me, Zhang Sj, Bruton J, Silva Jp, Reid Mb, Westerblad H, et al
JOURNAL OF PHYSIOLOGY-LONDON 2006;575(1):251-62

The effects of the myosin-II inhibitor N-benzyl-p-toluene sulphonamide on fatigue in mouse single intact toe muscle fibres
Bruton J, Pinniger Gj, Lannergren J, Westerblad H
ACTA PHYSIOLOGICA 2006;186(1):59-66

The role of Ca2+ influx for insulin-mediated glucose uptake in skeletal muscle
Lanner Jt, Katz A, Tavi P, Sandstrom Me, Zhang Sj, Wretman C, et al
DIABETES 2006;55(7):2077-83

Abnormal Ca2+ release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy
Tavi P, Hansson A, Zhang Sj, Larsson Ng, Westerblad H
HUMAN MOLECULAR GENETICS 2005;14(8):1069-76

Effects of a myosin-II inhibitor (N-benzyl-p-toluene sulphonamide, BTS) on contractile characteristics of intact fast-twitch mammalian muscle fibres
Pinniger G, Bruton J, Westerblad H, Ranatunga K
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 2005;26(2-3):135-41

Generation and phenotypic characterization of a galanin overexpressing mouse
Holmberg K, Kuteeva E, Brumovsky P, Kahl U, Karlstrom H, Lucas Ga, et al
NEUROSCIENCE 2005;133(1):59-77

Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha(1)
Tavi P, Sjogren M, Lunde Pk, Zhang Sj, Abbate F, Vennstrom B, et al
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2005;38(4):655-63

Insulin and inositol 1,4,5-trisphosphate trigger abnormal cytosolic Ca2+ transients and reveal mitochondrial Ca2+ handling defects in cardiomyocytes of ob/ob mice
Fauconnier J, Lanner Jt, Zhang Sj, Tavi P, Bruton Jd, Katz A, et al
DIABETES 2005;54(8):2375-81

Difference in skeletal muscle function in males vs. females: role of estrogen receptor-beta
Glenmark B, Nilsson M, Gao H, Gustafsson Ja, Dahlman-wright K, Westerblad H
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;287(6):E1125-31

Insulin-independent glycogen supercompensation in isolated mouse skeletal muscle: role of phosphorylase inactivation
Sandstrom Me, Abbate F, Andersson Dc, Zhang Sj, Westerblad H, Katz A
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2004;448(5):533-8

Pacing-induced calcineurin activation controls cardiac Ca2+ signalling and gene expression
Tavi P, Pikkarainen S, Ronkainen J, Niemela P, Ilves M, Weckstrom M, et al
JOURNAL OF PHYSIOLOGY-LONDON 2004;554(2):309-20

Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle
Tavi P, Allen Dg, Niemela P, Vuolteenaho O, Weckstrom M, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2003;551(1):5-12

CBA/J mice infected with Trypanosoma cruzi: An experimental model for inflammatory myopathies
Andersson J, Englund P, Sunnemark D, Dahlstedt A, Westerblad H, Nennesmo I, et al
MUSCLE & NERVE 2003;27(4):442-8

Cellular mechanisms of skeletal muscle fatigue
Westerblad H, Allen Dg
MOLECULAR AND CELLULAR ASPECTS OF MUSCLE CONTRACTION 2003;:563-70

Contraction-mediated glycogenolysis in mouse skeletal muscle lacking creatine kinase: the role of phosphorylase b activation
Katz A, Andersson Dc, Yu J, Norman B, Sandstrom Me, Wieringa B, et al
JOURNAL OF PHYSIOLOGY-LONDON 2003;553(2):523-31

Creatine kinase injection restores contractile function in creatine-kinase-deficient mouse skeletal muscle fibres
Dahlstedt Aj, Katz A, Tavi P, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2003;547(2):395-403

Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors
Johansson C, Lunde Pk, Gothe S, Lannergren J, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2003;547(3):789-96

Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions
Bruton J, Tavi P, Aydin J, Westerblad H, Lannergren J
JOURNAL OF PHYSIOLOGY-LONDON 2003;551(1):179-90

Mitochondrial function in intact skeletal muscle fibres of creatine kinase deficient mice
Bruton Jd, Dahlstedt Aj, Abbate F, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2003;552(2):393-402

Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion
Bruton Jd, Lemmens R, Shi Cl, Persson-sjögren S, Westerblad H, Ahmed M, et al
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):301-3

Dynamic vacuolation in skeletal muscle fibres after fatigue
Lannergren J, Westerblad H, Bruton Jd
CELL BIOLOGY INTERNATIONAL 2002;26(10):911-20

Effects of glucose on contractile function, [Ca2+](i), and glycogen in isolated mouse skeletal muscle
Helander I, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2002;282(6):C1306-12

Increased mitochondrial mass in mitochondrial myopathy mice
Wredenberg A, Wibom R, Wilhelmsson H, Graff C, Wiener Hh, Burden Sj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002;99(23):15066-71

Intracellular ATP measured with luciferin/luciferase in isolated single mouse skeletal muscle fibres
Allen Dg, Lannergren J, Westerblad H
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2002;443(5-6):836-42

Muscle fatigue: Lactic acid or inorganic phosphate the major cause?
Westerblad H, Allen Dg, Lannergren J
NEWS IN PHYSIOLOGICAL SCIENCES 2002;:17-21

Muscle fatigue: The role of intracellular calcium stores
Allen Dg, Kabbara Aa, Westerblad H
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE 2002;27(1):83-96

Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca2+](i)
Abbate F, Bruton Jd, De Haan A, Westerblad H
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2002;283(1):C42-7

Recent advances in the understanding of skeletal muscle fatigue
Westerblad H, Allen Dg
CURRENT OPINION IN RHEUMATOLOGY 2002;14(6):648-52

Regulation of myoplasmic Ca2+ in genetically obese (ob/ob) mouse single skeletal muscle fibres
Bruton Jd, Katz A, Lannergren J, Abbate F, Westerblad H
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2002;444(6):692-9

Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha - Involvement of muscle myofilaments
Reid Mb, Lannergren J, Westerblad H
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2002;166(4):479-84

Ryanodine receptors of pancreatic-cells mediate a distinct context-dependent signal for insulin secretion
Bruton Jd, Lemmens R, Shi Cl, Persson-sjogren S, Westerblad H, Ahmed M, et al
FASEB JOURNAL 2002;16(14):301-+

Changes in mitochondrial Ca2+ detected with Rhod-2 in single frog and mouse skeletal muscle fibres during and after repeated tetanic contractions
Lannergren J, Westerblad H, Bruton Jd
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 2001;22(3):265-75

Contractile response of skeletal muscle to low peroxide concentrations: myofibrillar calcium sensitivity as a likely target for redox-modulation
Andrade Fh, Reid Mb, Westerblad H
FASEB JOURNAL 2001;15(2):309-11

Contraction and intracellular Ca2+ handling in isolated skeletal muscle of rats with congestive heart failure
Lunde Pk, Dahlstedt Aj, Bruton Jd, Lannergren J, Thoren P, Sejersted Om, et al
CIRCULATION RESEARCH 2001;88(12):1299-305

Effects of concentric and eccentric contractions on phosphorylation of MAPK (erk1/2) and MAPK(38) in isolated rat skeletal muscle
Wretman C, Lionikas A, Widegren U, Lannergren J, Westerblad H, Henriksson J
JOURNAL OF PHYSIOLOGY-LONDON 2001;535(1):155-64

Inhibition of creatine kinase reduces the rate of fatigue-induced decrease in tetanic [Ca2+](i) in mouse skeletal muscle
Dahlstedt Aj, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2001;533(3):639-49

Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
Belluardo N, Westerblad H, Mudo G, Casabona A, Bruton J, Caniglia G, et al
MOLECULAR AND CELLULAR NEUROSCIENCE 2001;18(1):56-67

Properly formed but improperly localized synaptic specializations in the absence of laminin alpha 4
Patton Bl, Cunningham Jm, Thyboll J, Kortesmaa J, Westerblad H, Edstrom L, et al
NATURE NEUROSCIENCE 2001;4(6):597-604

Role of myoplasmic phosphate in contractile function of skeletal muscle: studies on creatine kinase-deficient mice
Dahlstedt Aj, Katz A, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2001;533(2):379-88

Role of phosphate and calcium stores in muscle fatigue
Allen Dg, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2001;536(3):657-65

The role of Ca2+ and calmodulin in insulin signalling in mammalian skeletal muscle
Bruton Jd, Katz A, Westerblad H
ACTA PHYSIOLOGICA SCANDINAVICA 2001;171(3):259-65

Differential activation of mitogen-activated protein kinase signalling pathways by isometric contractions in isolated slow- and fast-twitch rat skeletal muscle
Wretman C, Widegren U, Lionikas A, Westerblad H, Henriksson J
ACTA PHYSIOLOGICA SCANDINAVICA 2000;170(1):45-9

Frog skeletal muscle fibers recovering from fatigue have reduced charge movement
Bruton Jd, Szentesi P, Lannergren J, Westerblad H, Kovacs L, Csernoch L
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 2000;21(7):621-8

Functional significance of Ca2+ in long-lasting fatigue of skeletal muscle
Westerblad H, Bruton Jd, Allen Dg, Lannergren J
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;83(2-3):166-74

Is creatine kinase responsible for fatigue? Studies of isolated skeletal muscle deficient in creatine kinase
Dahlstedt Aj, Katz A, Wieringa B, Westerblad H
FASEB JOURNAL 2000;14(7):982-90

Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha(1)- or -beta-deficient mice
Johansson C, Lannergren J, Lunde Pk, Vennstrom B, Thoren P, Westerblad H
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2000;278(3):R598-603

Vacuole formation in fatigued skeletal muscle fibres from frog and mouse: effects of extracellular lactate
Lannergren J, Bruton Jd, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 2000;526(3):597-611

Insulin increases near-membrane but not global Ca2+ in isolated skeletal muscle
Bruton Jd, Katz A, Westerblad H
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999;96(6):3281-6

The use of caged adenine nucleotides and caged phosphate in intact skeletal muscle fibres of the mouse
Allen Dg, Lannergren J, Westerblad H
ACTA PHYSIOLOGICA SCANDINAVICA 1999;166(4):341-7

Vacuole formation in fatigued single muscle fibres from frog and mouse
Lannergren J, Bruton Jd, Westerblad H
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 1999;20(1):19-32

Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse
Andrade Fh, Reid Mb, Allen Dg, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 1998;509(2):565-75

Effect of nitric oxide on single skeletal muscle fibres from the mouse
Andrade Fh, Reid Mb, Allen Dg, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 1998;509(2):577-86

Effects of CO2-induced acidification on the fatigue resistance of single mouse muscle fibers at 28 degrees C
Bruton Jd, Lannergren J, Westerblad H
JOURNAL OF APPLIED PHYSIOLOGY 1998;85(2):478-83

Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle
Westerblad H, Andrade Fh, Islam Ms
CELL CALCIUM 1998;24(2):105-15

In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
Islam Ms, Leibiger I, Leibiger B, Rossi D, Sorrentino V, Ekstrom Tj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1998;95(11):6145-50

Mechanisms underlying reduced maximum shortening velocity during fatigue of intact, single fibres of mouse muscle
Westerblad H, Dahlstedt Aj, Lannergren J
JOURNAL OF PHYSIOLOGY-LONDON 1998;510(1):269-77

Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue
Westerblad H, Allen Dg, Bruton Jd, Andrade Fh, Lannergren J
ACTA PHYSIOLOGICA SCANDINAVICA 1998;162(3):253-60

Mechanisms underlying the slow recovery of force after fatigue: importance of intracellular calcium
Bruton Jd, Lannergren J, Westerblad H
ACTA PHYSIOLOGICA SCANDINAVICA 1998;162(3):285-93

C-peptide does not alter carbohydrate metabolism in isolated mouse muscle
Shashkin Pn, Jiao Y, Westerblad H, Katz A
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1997;272(2):E245-7

Increased tetanic force and reduced myoplasmic [P-i] following a brief series of tetani in mouse soleus muscle
Bruton Jd, Wretman C, Katz A, Westerblad H
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 1997;272(3):C870-4

Slowed relaxation in fatigued skeletal muscle fibers of Xenopus and mouse contribution of [Ca2+](i) and cross-bridges
Westerblad H, Lannergren J, Allen Dg
JOURNAL OF GENERAL PHYSIOLOGY 1997;109(3):385-99

The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature
Westerblad H, Bruton Jd, Lannergren J
JOURNAL OF PHYSIOLOGY-LONDON 1997;500(1):193-204

The role of ATP in the regulation of intracellular Ca2+ release in single fibres of mouse skeletal muscle
Allen Dg, Lannergren J, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 1997;498(3):587-600

Augmented force output in skeletal muscle fibres of Xenopus following a preceding bout of activity
Bruton Jd, Westerblad H, Katz A, Lannergren J
JOURNAL OF PHYSIOLOGY-LONDON 1996;493(1):211-7

Effects of repetitive tetanic stimulation at long intervals on excitation-contraction coupling in frog skeletal muscle
Bruton Jd, Lannergren J, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 1996;495(1):15-22

Mechanisms underlying changes of tetanic [Ca2+](i) and force in skeletal muscle
Westerblad H, Allen Dg
ACTA PHYSIOLOGICA SCANDINAVICA 1996;156(3):407-16

Reversible depression of action potentials and force production in frog single muscle fibres by calmodulin-inhibitors
Bruton Jd, Westerblad H, Lannergren J
ACTA PHYSIOLOGICA SCANDINAVICA 1996;156(4):441-6

Slow recovery of force in single skeletal muscle fibres
Lannergren J, Westerblad H, Bruton Jd
ACTA PHYSIOLOGICA SCANDINAVICA 1996;156(3):193-202

EFFECTS OF CGS 9343B (A PUTATIVE CALMODULIN ANTAGONIST) ON ISOLATED SKELETAL-MUSCLE - DISSOCIATION OF SIGNALING PATHWAYS FOR INSULIN-MEDIATED ACTIVATION OF GLYCOGEN-SYNTHASE AND HEXOSE-TRANSPORT
Shashkin P, Koshkin A, Langley D, Ren Jm, Westerblad H, Katz A
JOURNAL OF BIOLOGICAL CHEMISTRY 1995;270(43):25613-8

INSULIN-MEDIATED ACTIVATION OF GLYCOGEN-SYNTHASE IN ISOLATED SKELETAL-MUSCLE - ROLE OF MITOCHONDRIAL RESPIRATION
Katz A, Westerblad H
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1995;1244(1):229-32

MECANOSENSITIVE LINKAGE IN EXCITATION-CONTRACTION COUPLING IN FROG SKELETAL-MUSCLE
Bruton Jd, Lannergren J, Westerblad H
JOURNAL OF PHYSIOLOGY-LONDON 1995;484(3):737-42

MUSCLE-CELL FUNCTION DURING PROLONGED ACTIVITY - CELLULAR MECHANISMS OF FATIGUE
Allen Dg, Lannergren J, Westerblad H
EXPERIMENTAL PHYSIOLOGY 1995;80(4):497-527

REDUCED MAXIMUM SHORTENING VELOCITY IN THE ABSENCE OF PHOSPHOCREATINE OBSERVED IN INTACT FIBERS OF XENOPUS SKELETAL-MUSCLE
Westerblad H, Lannergren J
JOURNAL OF PHYSIOLOGY-LONDON 1995;482(2):383-90

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