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Goncalo Castelo-Branco

Associate professor

About me

Current position: Associate Professor and Principle Investigator

Research group's website

 

Main interests: Epigenetics, non-coding RNAs, transcription, oligodendrocyte development, remyelination, multiple sclerosis, neural stem cells, pluripotency

 

Previous research appointments

Kouzarides' lab, The Gurdon Institute, University of Cambridge, United Kingdom
Hermanson's lab, Department of Neuroscience, Karolinska Institutet, Sweden
Arenas's lab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden
Saraiva's lab, Institute for Molecular and Cellular Biology, University of Porto, Portugal

Education

Associate Professor (Docent), Karolinska Institutet, Stockholm, Sweden

Post-doctoral fellow, The Gurdon Institute, University of Cambridge, United Kingdom

Post-doctoral fellow, Department of Neuroscience, Karolinska Institutet, Sweden

PhD, Medical Biochemistry, Karolinska Institutet, Sweden

B.Sc., Biochemistry, University of Coimbra, Portugal

Research description

Our research group is interested in the molecular mechanisms defining the epigenetic state of stem/progenitor cells, such as pluripotent cells and oligodendrocyte precursor cells. We are particularly focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contributes to the transition between epigenetic states in oligodendrocyte precursor cells, and could thereby lead to targeted therapies for illnesses such as multiple sclerosis.

Selected publications: 

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Sueli Marques†, Amit Zeisel†, Simone Codeluppi, David van Bruggen, Ana Mendanha Falcão, Lin Xiao, Huiliang Li, Martin Häring, Hannah Hochgerner, Roman A. Romanov, Daniel Gyllborg, Ana Muñoz Manchado, Gioele La Manno, Peter Lönnerberg, Elisa M. Floriddia, Fatemah Rezayee, Patrik Ernfors, Ernest Arenas, Jens Hjerling-Leffler, Tibor Harkany, William D. Richardson, Sten Linnarsson*, Gonçalo Castelo-Branco*

SCIENCE 2016, in press

*Co-corresponding and senior author

 

 

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Amit Zeisel†, Ana B. Muñoz Manchado†, Simone Codeluppi, Peter Lönnerberg, Gioele La Manno, Anna Juréus, Sueli Marques, Hermany Munguba, Liqun He, Christer Betsholtz, Charlotte Rolny, Gonçalo Castelo-Branco§, Jens Hjerling-Leffler1* and Sten Linnarsson*

Science 2015

§ Senior author

 

Neural Stem Cell Differentiation Is Dictated by Distinct Actions of Nuclear Receptor Corepressors and Histone Deacetylases

Gonçalo Castelo-Branco*, Tobias Lilja, Karolina Wallenborg, Ana M. FalcãoSueli C. Marques, Aileen Gracias, Derek Solum, Ricardo Paap, Julian Walfridsson, Ana I. Teixeira, Michael G. Rosenfeld, Kristen Jepsen, Ola Hermanson*

* Co-corresponding and senior author

Stem Cell Reports  2014, Volume 3, 1-4

 

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Christophorou MA*, Castelo-Branco G*, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T.

* equal contribution, co-first authors

 Nature 2014, 507(7490):104-8

 

Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.

Castelo-Branco G*, Stridh P, Guerreiro-Cacais AO, Adzemovic MZ, Falcão AM, Marta M, Berglund R, Gillett A, Hamza KH, Lassmann H, Hermanson O, Jagodic M.*
 

* Co-corresponding and senior author

Neurobiology of Disease 2014

 

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells.

Castelo-Branco G, Amaral PP, Engström PG, Robson SC, Marques SC, Bertone P, Kouzarides T.

Genome Biology 2013 Sep 17;14(9):R98. 

 

In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.

Raju CS, Göritz C, Nord Y, Hermanson O, López-Iglesias C, Visa N, Castelo-Branco G, Percipalle P.

Mol Biol Cell. 2008 Jul;19(7):3008-19

 

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.

Andäng M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, El Manira A, Ibañez CF, Ernfors P.

Nature. 2008 Jan 24;451(7177):460-4.

 

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice.

Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E.

J Clin Invest. 2008 Jan;118(1):149-60.

 

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a.

Castelo-Branco G, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, Pasolli HA, Fuchs E, Kitajewski J, Arenas E.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12747-52.

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