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Erik Melén

Associate professor

Visiting address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden
Postal address : Institute of Environmental Medicine (IMM), C6, Environmental epidemiology, Box 210 171 77 Stockholm, Sweden
Delivery address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden

About me

Current positions

  • Associate professor, Institute of Environmental Medicine
  • Pediatric allergist, Sachs’ Children’s Hospital
  • PI of the BAMSE study

Education

  • 2017: Specialist in Pediatric allergy
  • 2012: Associate Professor
  • 2012: Specialist in Pediatrics
  • 2009-10: Postdoc, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
  • 2006: PhD, Karolinska Institutet (Epidemiology). Title: Genetic studies on childhood asthma and allergy - role of interactions
  • 2005: License to practice (certified by the Swedish National Board of Health and Welfare)
  • 2001: MD, University of Uppsala, Sweden

Research description

Respiratory and allergic diseases in children; role of genetic and environmental factors

My research projects aim to advance the understanding about the complex interplay between genetic and environmental factors involved in lung growth, respiratory and allergic diseases in children. The projects are primarily based on a Swedish birth cohort, BAMSE that allows for unique investigation of lung function, respiratory and allergic diseases in a large number of children up to 16 years. Detailed information about perinatal events, environmental exposures such as air pollution and tobacco smoke exposure from birth and onwards has been collected. To bridge childhood and adulthood research on respiratory and allergic diseases, we have just started a new follow-up when the participants are 22-24 years of age.

In our ongoing genetics projects, genome-wide approaches are primarily used (GWAS, global methylation analyses and RNA sequencing / microarray approaches) together with detailed clinical and epidemiological data. Extensive national and international collaboration is established (e.g. through the GABRIEL, EAGLE and MeDALL projects). Close collaboration with several colleagues within the Centre for Allergy Network as well as Sachs Children’s and Astrid Lindgren Children’s Hospitals is ongoing. From this “Environmental genomics research platform” for advanced studies using clinical and epidemiological data sets, we are performing projects that will generate exciting new information in areas that have been little explored so far. For example, the long-term consequence of preterm birth on lung function in young adulthood; identification of subgroups of the population that are particularly vulnerable to air pollution exposures; clarification of new genetic mechanisms for disease development.

 

Research group (Pediatric Pulmonology & Genetics Group)

  • Olena Gruzieva, MD, postdoc
  • Jenny Hallberg, PhD, researcher
  • Simon Kebede Merid, Bioinformatician
  • Ashish Kumar, Bioinformatician / Statistician
  • Erica Schultz, MD, PhD
  • Per Thunqvist, MD, PhD
  • Anand Andiappan, PhD (guest researcher)

Financing

  • ERC
  • The Swedish Heart-Lung Foundation
  • VR
  • ALF
  • SFO Epidemiology, KI
  • KI-SLL (Klinisk forskare)
  • Frimurare Barnhuset, Stockholm
  • Cancer- och Allergifonden

Academic honours, awards and prizes

  • Prins Daniel's young investigator award from The Swedish Heart-Lung Foundation 2015 (link here)
  • Major research award from The Swedish Association For Allergology 2016 (link here)
  • PhARF / EAACI Allergy Award 2017
  • ERC Starting grant 2017

Publications

Anaphylactic Reactions to Novel Foods: Case Report of a Child With Severe Crocodile Meat Allergy
Ballardini N, Nopp A, Hamsten C, Vetander M, Melén E, Nilsson C, et al
Pediatrics 2017;139(4):-

Body Mass Index Development and Asthma Throughout Childhood
Ekstrom S, Magnusson J, Kull I, Andersson N, Bottai M, Pour Mb, et al
AMERICAN JOURNAL OF EPIDEMIOLOGY 2017;186(2):255-263

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA
Bousquet J, Bewick M, Cano A, Eklund P, Fico G, Goswami N, et al
The journal of nutrition, health & aging 2017;21(1):92-104

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium
Felix Jf, Joubert Br, Baccarelli Aa, Sharp Gc, Almqvist C, Annesi-maesano I, et al
International journal of epidemiology 2017;():-

Computational analysis of multimorbidity between asthma, eczema and rhinitis
Aguilar D, Pinart M, Koppelman Gh, Saeys Y, Nawijn Mc, Postma Ds, et al
PloS one 2017;12(6):e0179125-

Dietary total antioxidant capacity in early school age and subsequent allergic disease
Gref A, Rautiainen S, Gruzieva O, Håkansson N, Kull I, Pershagen G, et al
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017;47(6):751-759

Effects of Long-Term Exposure to Traffic-Related Air Pollution on Lung Function in Children
Schultz Es, Litonjua Aa, Melén E
Current allergy and asthma reports 2017;17(6):41-

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
Gruzieva O, Xu Cj, Breton Cv, Annesi-maesano I, Antó Jm, Auffray C, et al
Environmental health perspectives 2017;125(1):104-110

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
Bousquet J, Farrell J, Crooks G, Hellings P, Bel Eh, Bewick M, et al
Clinical and translational allergy 2017;7():5-

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children
Gruzieva O, Merid Sk, Gref A, Gajulapuri A, Lemonnier N, Ballereau S, et al
Environmental health perspectives 2017;125(6):67007-

Genetic and epigenetic regulation of YKL-40 in childhood
Guerra S, Melén E, Sunyer J, Xu Cj, Lavi I, Benet M, et al
The Journal of allergy and clinical immunology 2017;():-

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up
Gref A, Merid Sk, Gruzieva O, Ballereau S, Becker A, Bellander T, et al
American journal of respiratory and critical care medicine 2017;195(10):1373-1383

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia
Um-bergström P, Hallberg J, Thunqvist P, Berggren-broström E, Anderson M, Adenfelt G, et al
BMC pulmonary medicine 2017;17(1):97-

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Sharp Gc, Salas La, Monnereau C, Allard C, Yousefi P, Everson Tm, et al
Human molecular genetics 2017;26(20):4067-4085

Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
Anto Jm, Bousquet J, Akdis M, Auffray C, Keil T, Momas I, et al
The Journal of allergy and clinical immunology 2017;139(2):388-399

Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort
Thacher Jd, Gruzieva O, Pershagen G, Melén E, Lorentzen Jc, Kull I, et al
Allergy 2017;72(6):967-974

Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma
Acevedo N, Ezer S, Kebede Merid S, Gaertner Vd, Söderhäll C, D'amato M, et al
PloS one 2017;12(5):e0176568-

Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study
Bousquet J, Caimmi Dp, Bedbrook A, Bewick M, Hellings Pw, Devillier P, et al
Allergy 2017;72(6):857-865

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort
Asarnoj A, Hamsten C, Lupinek C, Melén E, Andersson N, Anto Jm, et al
The Journal of allergy and clinical immunology 2017;140(2):587-590.e7

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium
Farzan N, Vijverberg Sj, Andiappan Ak, Arianto L, Berce V, Blanca-lópez N, et al
Pharmacogenomics 2017;18(10):931-943

Recent advances in understanding lung function development
Melén E, Guerra S
F1000Research 2017;6():726-

Sensitization trajectories in childhood revealed by using a cluster analysis
Schoos Am, Chawes Bl, Melén E, Bergström A, Kull I, Wickman M, et al
The Journal of allergy and clinical immunology 2017;():-

Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
Siroux V, Lupinek C, Resch Y, Curin M, Just J, Keil T, et al
The Journal of allergy and clinical immunology 2017;139(2):643-654.e6

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study
Bousquet J, Arnavielhe S, Bedbrook A, Fonseca J, Morais Almeida M, Todo Bom A, et al
Allergy 2017;():-

The emerging landscape of dynamic DNA methylation in early childhood
Xu Cj, Bonder Mj, Soderhall C, Bustamante M, Baiz N, Gehring U, et al
BMC GENOMICS 2017;:25-

The sex-shift in single disease and multimorbid asthma and rhinitis during puberty
Keller T, Hohmann C, Standl M, Wijga Ah, Gehring U, Melén E, et al
Allergy 2017;():-

Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project)
Bousquet J, Agache I, Aliberti Mr, Angles R, Annesi-maesano I, Anto Jm, et al
Allergy 2017;():-

Work productivity in rhinitis using cell phones: The MASK pilot study
Bousquet J, Bewick M, Arnavielhe S, Mathieu-dupas E, Murray R, Bedbrook A, et al
Allergy 2017;72(10):1475-1484

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Bousquet J, Hellings Pw, Agache I, Bedbrook A, Bachert C, Bergmann Kc, et al
Clinical and translational allergy 2016;6():47-

Asthma phenotypes and lung function up to 16 years of age-the BAMSE cohort (vol 70, pg 667, 2015)
Hallberg J, Thunqvist P, Schultz Es, Kull I, Bottai M, Merritt As, et al
ALLERGY 2016;71(8):1228-9

Characterization of genetic variation in TLR8 in relation to allergic rhinitis
Henmyr V, Lind-halldén C, Carlberg D, Halldén C, Melén E, Wickman M, et al
Allergy 2016;71(3):333-41

DNA methylation and genetic polymorphisms of the Leptin gene interact to influence lung function outcomes and asthma at 18 years of age
Mukherjee N, Lockett Ga, Merid Sk, Melén E, Pershagen G, Holloway Jw, et al
International journal of molecular epidemiology and genetics 2016;7(1):1-17

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Joubert Br, Felix Jf, Yousefi P, Bakulski Km, Just Ac, Breton C, et al
American journal of human genetics 2016;98(4):680-96

Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages
Schieck M, Schouten Jp, Michel S, Suttner K, Toncheva Aa, Gaertner Vd, et al
The Journal of allergy and clinical immunology 2016;138(2):421-31

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children
Den Dekker Ht, Sonnenschein-van Der Voort Amm, De Jongste Jc, Anessi-maesano I, Arshad Sh, Barros H, et al
The Journal of allergy and clinical immunology 2016;137(4):1026-1035

Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence
Schultz Es, Hallberg J, Bellander T, Bergström A, Bottai M, Chiesa F, et al
American journal of respiratory and critical care medicine 2016;193(2):171-7

Early life exposure to traffic-related air pollution and lung function in adolescence assessed with impulse oscillometry
Schultz Es, Hallberg J, Gustafsson Pm, Bottai M, Bellander T, Bergström A, et al
The Journal of allergy and clinical immunology 2016;138(3):930-932.e5

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development
Miller S, Melén E, Merid Sk, Hall Ip, Sayers I
Respiratory research 2016;17(1):95-

Heritability and confirmation of genetic association studies for childhood asthma in twins
Ullemar V, Magnusson Pk, Lundholm C, Zettergren A, Melén E, Lichtenstein P, et al
Allergy 2016;71(2):230-8

IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence
Ballardini N, Bergström A, Wahlgren Cf, Van Hage M, Hallner E, Kull I, et al
Allergy 2016;71(3):342-9

Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study
Thunqvist P, Gustafsson Pm, Schultz Es, Bellander T, Berggren-brostrom E, Norman M, et al
PEDIATRICS 2016;137(4):-

Parental smoking and development of allergic sensitization from birth to adolescence
Thacher Jd, Gruzieva O, Pershagen G, Neuman Å, Van Hage M, Wickman M, et al
Allergy 2016;71(2):239-48

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015
Bousquet J, Anto Jm, Akdis M, Auffray C, Keil T, Momas I, et al
Allergy 2016;71(11):1513-1525

Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma
Hamsten C, Haggmark A, Grundstrom J, Mikus M, Lindskog C, Konradsen Jr, et al
ALLERGY 2016;71(9):1357-61

Reply: Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence
Schultz Es, Hallberg J, Pershagen G, Melén E
American journal of respiratory and critical care medicine 2016;194(3):385-6

Rhinovirus-specific antibody responses in preschool children with acute wheeze reflect severity of respiratory symptoms
Stenberg-hammar K, Niespodziana K, Söderhäll C, James A, Cabauatan Cr, Konradsen Jr, et al
Allergy 2016;71(12):1728-1735

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
Bousquet J, Farrell J, Crooks G, Hellings P, Bel Eh, Bewick M, et al
CLINICAL AND TRANSLATIONAL ALLERGY 2016;:29-

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
Miller S, Henry Ap, Hodge E, Kheirallah Ak, Billington Ck, Rimington Tl, et al
PloS one 2016;11(10):e0164041-

A novel common variant in DCST2 is associated with length in early life and height in adulthood
Van Der Valk Rj, Kreiner-møller E, Kooijman Mn, Guxens M, Stergiakouli E, Sääf A, et al
Human molecular genetics 2015;24(4):1155-68

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis
Bousquet J, Anto Jm, Wickman M, Keil T, Valenta R, Haahtela T, et al
Allergy 2015;70(9):1062-78

Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts
Fuertes E, Söderhäll C, Acevedo N, Becker A, Brauer M, Chan-yeung M, et al
The Journal of allergy and clinical immunology 2015;135(2):573-6

Asthma phenotypes and lung function up to 16 years of age-the BAMSE cohort
Hallberg J, Thunqvist P, Schultz Es, Kull I, Bottai M, Merritt As, et al
Allergy 2015;70(6):667-73

Developmental determinants in non-communicable chronic diseases and ageing
Bousquet J, Anto Jm, Berkouk K, Gergen P, Antunes Jp, Augé P, et al
Thorax 2015;70(6):595-7

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
Qi Q, Downer Mk, Kilpeläinen To, Taal Hr, Barton Sj, Ntalla I, et al
Diabetes 2015;64(7):2467-76

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection
Everson Tm, Lyons G, Zhang H, Soto-ramírez N, Lockett Ga, Patil Vk, et al
Genome medicine 2015;7():89-

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study
Gehring U, Wijga Ah, Hoek G, Bellander T, Berdel D, Bruske I, et al
LANCET RESPIRATORY MEDICINE 2015;3(12):933-42

Exposure to grass pollen--but not birch pollen--affects lung function in Swedish children
Gruzieva O, Pershagen G, Wickman M, Melén E, Hallberg J, Bellander T, et al
Allergy 2015;70(9):1181-3

Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis
Magnusson J, Kull I, Westman M, Håkansson N, Wolk A, Melén E, et al
The Journal of allergy and clinical immunology 2015;136(5):1247-53.e1

GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy
Heinonen Mt, Laine Ap, Söderhäll C, Gruzieva O, Rautio S, Melén E, et al
Journal of immunology (Baltimore, Md. : 1950) 2015;194(12):5885-94

Influence of the Consumption of Fish and polyunsaturated Fatty Acids on the Development of allergic and non-allergic Rhinitis
Magnusson J, Kull I, Westman M, Hakansson N, Wolk A, Melen E, et al
ALLERGOLOGIE 2015;38(8):425-426

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation
Bousquet J, Schunemann Hj, Fonseca J, Samolinski B, Bachert C, Canonica Gw, et al
Allergy 2015;70(11):1372-92

Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age
Ekstrom S, Magnusson J, Kull I, Lind T, Almqvist C, Melen E, et al
CLINICAL AND EXPERIMENTAL ALLERGY 2015;45(1):283-91

Meta-analysis identifies seven susceptibility loci involved in the atopic march
Marenholz I, Esparza-gordillo J, Rüschendorf F, Bauerfeind A, Strachan Dp, Spycher Bd, et al
Nature communications 2015;6():8804-

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Early Genetics Lifecourse Epidemio, Aagc, Paternoster L, Standl M, Waage J, Baurecht H, et al
NATURE GENETICS 2015;47(12):1449-1456

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Wain Lv, Shrine N, Miller S, Jackson Ve, Ntalla I, Soler Artigas M, et al
The Lancet. Respiratory medicine 2015;3(10):769-81

Operational Definition of Active and Healthy Ageing (AHA): A Conceptual Framework
Bousquet J, Kuh D, Bewick M, Standberg T, Farrell J, Pengelly R, et al
The journal of nutrition, health & aging 2015;19(9):955-60

Operative definition of active and healthy ageing (AHA): Meeting report. Montpellier October 20-21, 2014
Bousquet J, Kuh D, Bewick M, Strandberg T, Farrell J, Pengelly R, et al
EUROPEAN GERIATRIC MEDICINE 2015;6(2):196-200

Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster
Garcia-aymerich J, Benet M, Saeys Y, Pinart M, Basagaña X, Smit Ha, et al
Allergy 2015;70(8):973-84

Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study
Guerra S, Halonen M, Vasquez Mm, Spangenberg A, Stern Da, Morgan Wj, et al
The Lancet. Respiratory medicine 2015;3(8):613-20

Reversal of Immunoglobulin A Deficiency in Children
Lim Ck, Dahle C, Elvin K, Andersson Ba, Ronnelid J, Melen E, et al
JOURNAL OF CLINICAL IMMUNOLOGY 2015;35(1):87-91

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus
Acevedo N, Reinius Le, Greco D, Gref A, Orsmark-pietras C, Persson H, et al
Human molecular genetics 2015;24(3):875-90

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Soler Artigas M, Wain Lv, Miller S, Kheirallah Ak, Huffman Je, Ntalla I, et al
Nature communications 2015;6():8658-

The use of the MeDALL-chip to assess IgE sensitization: a new diagnostic tool for allergic disease?
Skrindo I, Lupinek C, Valenta R, Hovland V, Pahr S, Baar A, et al
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2015;26(3):239-246

Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles
Persson H, Kwon At, Ramilowski Ja, Silberberg G, Söderhäll C, Orsmark-pietras C, et al
The Journal of allergy and clinical immunology 2015;136(3):638-48

Allergy-related diseases and recurrent abdominal pain during childhood - a birth cohort study
Olén O, Neuman Å, Koopmann B, Ludvigsson Jf, Ballardini N, Westman M, et al
Alimentary pharmacology & therapeutics 2014;40(11-12):1349-58

An update on epigenetics and childhood respiratory diseases
Gruzieva O, Mend Sk, Melen E
PAEDIATRIC RESPIRATORY REVIEWS 2014;15(4):348-54

Bridging genetics, epidemiology, and respiratory medicine
Melén E
American journal of respiratory and critical care medicine 2014;190(7):716-8

Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort
Wickman M, Asarnoj A, Tillander H, Andersson N, Bergström A, Kull I, et al
The Journal of allergy and clinical immunology 2014;133(2):580-2

Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study
Pinart M, Benet M, Annesi-maesano I, Von Berg A, Berdel D, Carlsen Kc, et al
The Lancet. Respiratory medicine 2014;2(2):131-40

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants
Van Der Valk Rj, Duijts L, Timpson Nj, Salam Mt, Standl M, Curtin Ja, et al
The Journal of allergy and clinical immunology 2014;134(1):46-55

Genome-wide association analysis identifies six new loci associated with forced vital capacity
Loth Dw, Soler Artigas M, Gharib Sa, Wain Lv, Franceschini N, Koch B, et al
Nature genetics 2014;46(7):669-77

GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study
Macintyre Ea, Brauer M, Melén E, Bauer Cp, Bauer M, Berdel D, et al
Environmental health perspectives 2014;122(4):418-24

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L
Viktorin A, Frankowiack M, Padyukov L, Chang Z, Melén E, Sääf A, et al
Human molecular genetics 2014;23(15):4177-84

Integrated care pathways for airway diseases (AIRWAYS-ICPs)
European Innovation Partnership On Active And Healthy Ageing Action Plan B3, Mechanisms Of The Development Of Allergy Wp 10, Global Alliance Against Chronic Respiratory Diseases, Bousquet J, Addis A, Adcock I, et al
The European respiratory journal 2014;44(2):304-23

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure
Scholtens S, Postma Ds, Moffatt Mf, Panasevich S, Granell R, Henderson Aj, et al
The Journal of allergy and clinical immunology 2014;133(3):885-8

NPSR1 polymorphisms influence recurrent abdominal pain in children: a population-based study
Henström M, Zucchelli M, Söderhäll C, Bergström A, Kere J, Melén E, et al
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2014;26(10):1417-25

Pre- and postnatal exposure to parental smoking and allergic disease through adolescence
Thacher Jd, Gruzieva O, Pershagen G, Neuman Å, Wickman M, Kull I, et al
Pediatrics 2014;134(3):428-34

Prevalence of severe childhood asthma according to the WHO
Nordlund B, Melén E, Schultz Es, Grönlund H, Hedlin G, Kull I
Respiratory medicine 2014;108(8):1234-7

Replication of genomewide associations with allergic sensitization and allergic rhinitis
Nilsson D, Henmyr V, Halldén C, Säll T, Kull I, Wickman M, et al
Allergy 2014;69(11):1506-14

Risk factors and markers of asthma control differ between asthma subtypes in children
Nordlund B, Melén E, Schultz Es, Grönlund H, Hedlin G, Kull I
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2014;25(6):558-64

Subnormal levels of vitamin D are associated with acute wheeze in young children
Stenberg Hammar K, Hedlin G, Konradsen Jr, Nordlund B, Kull I, Giske Cg, et al
Acta paediatrica (Oslo, Norway : 1992) 2014;103(8):856-61

The development of the MeDALL Core Questionnaires for a harmonized follow-up assessment of eleven European birth cohorts on asthma and allergies
Hohmann C, Pinart M, Tischer C, Gehring U, Heinrich J, Kull I, et al
International archives of allergy and immunology 2014;163(3):215-24

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis
Weidinger S, Willis-owen Sa, Kamatani Y, Baurecht H, Morar N, Liang L, et al
Human molecular genetics 2013;22(23):4841-56

Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study
Tag Study Grp, Fuertes E, Brauer M, Macintyre E, Bauer M, Bellander T, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2013;132(2):342-52.e2

DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors
Reinius Le, Gref A, Sääf A, Acevedo N, Joerink M, Kupczyk M, et al
PloS one 2013;8(1):e53877-

Exposure to Air Pollution from Traffic and Childhood Asthma Until 12 Years of Age
Gruzieva O, Bergstrom A, Hulchiy O, Kull I, Lind T, Melen E, et al
EPIDEMIOLOGY 2013;24(1):54-61

Fish consumption in infancy and development of allergic disease up to age 12 y
Magnusson J, Kull I, Rosenlund H, Håkansson N, Wolk A, Melén E, et al
The American journal of clinical nutrition 2013;97(6):1324-30

Genome-wide association study of body mass index in 23 000 individuals with and without asthma
Melén E, Granell R, Kogevinas M, Strachan D, Gonzalez Jr, Wjst M, et al
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2013;43(4):463-74

Glutathione-S-transferase P1, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta-analysis
Tischer Cg, Gref A, Standl M, Bauer M, Bergstrom A, Brauer M, et al
ALLERGY 2013;68(3):339-46

GSTCD and INTS12 Regulation and Expression in the Human Lung
Obeidat M, Miller S, Probert K, Billington Ck, Henry Ap, Hodge E, et al
PLOS ONE 2013;8(9):e74630-

HTR4 gene structure and altered expression in the developing lung
Hodge E, Nelson Cp, Miller S, Billington Ck, Stewart Ce, Swan C, et al
RESPIRATORY RESEARCH 2013;:77-

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma
Acevedo N, Sääf A, Söderhäll C, Melén E, Mandelin J, Pietras Co, et al
PloS one 2013;8(4):e60111-

Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report
Panasevich S, Melén E, Hallberg J, Bergström A, Svartengren M, Pershagen G, et al
Acta paediatrica (Oslo, Norway : 1992) 2013;102(5):498-503

Lung development in children: role of genetic and environmental factors
Schultz Es, Melén E
Acta paediatrica (Oslo, Norway : 1992) 2013;102(7):672-4

Rule-based models of the interplay between genetic and environmental factors in childhood allergy
Bornelöv S, Sääf A, Melén E, Bergström A, Torabi Moghadam B, Pulkkinen V, et al
PloS one 2013;8(11):e80080-

The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma
Konradsen Jr, James A, Nordlund B, Reinius Le, Söderhäll C, Melén E, et al
The Journal of allergy and clinical immunology 2013;132(2):328-35.e5

The link between parental allergy and offspring allergic and nonallergic rhinitis
Westman M, Kull I, Lind T, Melen E, Stjarne P, Toskala E, et al
ALLERGY 2013;68(12):1571-8

Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma
Macintyre Ea, Carlsten C, Macnutt M, Fuertes E, Melen E, Tiesler Cmt, et al
EUROPEAN JOURNAL OF EPIDEMIOLOGY 2013;28(7):597-606

Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics
Orsmark-pietras C, James A, Konradsen Jr, Nordlund B, Söderhäll C, Pulkkinen V, et al
The European respiratory journal 2013;42(1):65-78

Air pollution, genetics, and allergy: an update
Carlsten C, Melen E
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY 2012;12(5):455-60

Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs
World Hlth Org Collaborating Ctr, Bousquet J, Schunemann Hj, Samolinski B, Demoly P, Baena-cagnani Ce, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012;130(5):1049-62

Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort
Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Ostblom E, et al
ALLERGY 2012;67(4):537-44

Genome-wide association study of the age of onset of childhood asthma
Forno E, Lasky-su J, Himes B, Howrylak J, Ramsey C, Brehm J, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012;130(1):83-90.e4

HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults
Sharp Investigators, Lasky-su J, Himes Be, Raby Ba, Klanderman Bj, Sylvia Js, et al
CLINICAL AND EXPERIMENTAL ALLERGY 2012;42(12):1724-33

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Early Genetics Lifecourse Epidemio, Genetics Overweight Young Adults G, Australian Asthma Genetics Consort, Paternoster L, Standl M, Chen Cm, et al
NATURE GENETICS 2012;44(2):187-92

On childhood asthma, obesity and inflammation
Bergstrom A, Melen E
CLINICAL AND EXPERIMENTAL ALLERGY 2012;42(1):5-7

On lung function and interactions using genome-wide data
Melén E, Bottai M
PLoS genetics 2012;8(12):e1003174-

Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma
Melen E, Pershagen G
JOURNAL OF INTERNAL MEDICINE 2012;272(2):108-20

Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children
Janzi M, Melen E, Kull I, Wickman M, Hammarstrom L
GENES AND IMMUNITY 2012;13(1):59-65

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA(2)LEN - ARIA Position Paper
Who Collaborating Ctr Asthma, Bousquet J, Anto Jm, Demoly P, Schunemann Hj, Togias A, et al
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 2012;158(3):216-31

Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
Gruzieva O, Bellander T, Eneroth K, Kull I, Melen E, Nordling E, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012;129(1):240-6

Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort study
Schultz Es, Gruzieva O, Bellander T, Bottai M, Hallberg J, Kull I, et al
American journal of respiratory and critical care medicine 2012;186(12):1286-91

A comprehensive analysis of the COL29A1 gene does not support a role in eczema
Naumann A, Soderhall C, Folster-holst R, Baurecht H, Harde V, Muller-wehling K, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2011;127(5):1187-94.e7

Expression analysis of asthma candidate genes during human and murine lung development
Melen E, Kho At, Sharma S, Gaedigk R, Leeder Js, Mariani Tj, et al
RESPIRATORY RESEARCH 2011;:86-

Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma
Bunyavanich S, Melen E, Wilk Jb, Granada M, Soto-quiros Me, Avila L, et al
Clinical and molecular allergy : CMA 2011;9():1-

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Gabriel Consortium, Moffatt Mf, Gut Ig, Demenais F, Strachan Dp, Bouzigon E, et al
NEW ENGLAND JOURNAL OF MEDICINE 2010;363(13):1211-1221

Analyses of shared genetic factors between asthma and obesity in children
Melen E, Himes Be, Brehm Jm, Boutaoui N, Klanderman Bj, Sylvia Js, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2010;126(3):631-7.e1

Assessment of the Neuropeptide S System in Anxiety Disorders
Donner J, Haapakoski R, Ezer S, Melen E, Pirkola S, Gratacos M, et al
BIOLOGICAL PSYCHIATRY 2010;68(5):474-83

Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren
Kull I, Melen E, Alm J, Hallberg J, Svartengren M, Van Hage M, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2010;125(5):1013-9

Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing
Panasevich S, Lindgren C, Kere J, Wickman M, Pershagen G, Nyberg F, et al
CLINICAL AND EXPERIMENTAL ALLERGY 2010;40(3):458-67

Problematic severe asthma in children, not one problem but many: a GA(2)LEN initiative
Problematic Severe Asthma, Hedlin G, Bush A, Carlsen Kl, Wennergren G, De Benedictis Fm, et al
EUROPEAN RESPIRATORY JOURNAL 2010;36(1):196-201

Exclusive breastfeeding reduces the risk of childhood eczema
Kull I, Bergstrom A, Alm J, Melen E, Bohme M, Wahlgren C, et al
ALLERGY 2009;:63-63

MMP12, Lung Function, and COPD in High-Risk Populations
Hunninghake Gm, Cho Mh, Tesfaigzi Y, Soto-quiros Me, Avila L, Lasky-su J, et al
NEW ENGLAND JOURNAL OF MEDICINE 2009;361(27):2599-608

Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood
Janzi M, Kull I, Sjoberg R, Wan J, Melen E, Bayat N, et al
CLINICAL IMMUNOLOGY 2009;133(1):78-85

The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms
Bruce S, Nyberg F, Melen E, James A, Pulkkinen V, Orsmark-pietras C, et al
JOURNAL OF MEDICAL GENETICS 2009;46(3):159-67

Biological and genetic interaction between Tenascin C and Neuropeptide S receptor 1 in allergic diseases
Parsifal Genet Study Grp, Orsmark-pietras C, Melen E, Vendelin J, Bruce S, Laitinen A, et al
HUMAN MOLECULAR GENETICS 2008;17(11):1673-82

Breastfeeding decreases the risk of asthma even up to 8 years
Kull I, Alm J, Hashemi N, Lind T, Svensson H, Melen E, et al
ALLERGY 2008;:52-52

Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
Melen E, Nyberg F, Lindgren Cm, Berglind N, Zucchelli M, Nordling E, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2008;116(8):1077-84

Longitudinal study on childhood wheezing and asthma in relation to birth weight and gestational age
Bergstrom A, Melen E, Hashemi N, Lind T, Svensson H, Kull I, et al
ALLERGY 2008;:470-470

Sex-specific influence of parental allergic disease on wheezing and asthma up to 8 years: a longitudinal analysis (BAMSE)
Melen E, Bergstrom A, Hashemi N, Lind T, Svensson H, Neuman A, et al
ALLERGY 2008;:465-465

Traffic-related air pollution and childhood respiratory symptoms, function and allergies
Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, et al
EPIDEMIOLOGY 2008;19(3):401-8

Gene-environment interactions of tumor necrosis factor single nucleoticle polymorphisms with passive smoking and development of asthma symptoms in early childhood
Panasevich S, Melen E, Lindgren C, Kere J, Wickman M, Pershagen G, et al
ALLERGY 2007;:58-58

Incidence, remission and severity of allergic disease in relation to sex among 1-8-year-old children in the BAMSE birth cohort
Neuman A, Kull I, Ostblom E, Melen E, Nordvall L, Wickman M
ALLERGY 2007;:84-85

Longitudinal analysis of sensitisation to common airborne allergens among 4-8 year old children in the BAMSE birth cohort
Asarnoj A, Kull I, Ostblom E, Melen E, Hedlin G, Wickman M
ALLERGY 2007;:85-85

Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood
Kull I, Bergstrom A, Melen E, Lilja G, Van Hage M, Pershagen G, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2006;118(6):1299-304

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis
Ekelund E, Saaf A, Tengvall-linder M, Melen E, Link J, Barker J, et al
AMERICAN JOURNAL OF HUMAN GENETICS 2006;78(6):1060-5

Exposure to traffic-related air pollution in early life affects lung function, airway disease, and sensitization in 4-year-old children
Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, et al
EPIDEMIOLOGY 2006;17(6):S148-S148

Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study
Melen E, Umerkajeff S, Nyberg F, Zucchelli M, Lindstedt A, Gullsten H, et al
CLINICAL AND EXPERIMENTAL ALLERGY 2006;36(11):1391-8

Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma
Parsifal Genetics Study Grp, Melen E, Bruce S, Doekes G, Kabesch M, Laitinen T, et al
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2005;171(10):1089-95

Phenylketonuria screening registry as a resource for population genetic studies
Hannelius U, Lindgren Cm, Melen E, Malmberg A, Von Dobeln U, Kere J
JOURNAL OF MEDICAL GENETICS 2005;42(10):e60-

Influence of male sex and parental allergic disease on childhood wheezing: role of interactions
Melen E, Kere J, Pershagen G, Svartengren M, Wickman M
CLINICAL AND EXPERIMENTAL ALLERGY 2004;34(6):839-44

Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation
Melen E, Gullsten H, Zucchelli M, Lindstedt A, Nyberg F, Wickman M, et al
JOURNAL OF MEDICAL GENETICS 2004;41(12):e123-

Interleukin 9 receptor gene polymorphisms in childhood wheezing end atopy.
Melen E, Gullsten H, Lindstedt A, Zucchelli M, Nyberg F, Pershagen G, et al
AMERICAN JOURNAL OF HUMAN GENETICS 2003;73(5):504-504

Strategies for preventing wheezing and asthma in small children
Wickman M, Melen E, Berglind N, Nordvall Sl, Almqvist C, Kull I, et al
ALLERGY 2003;58(8):742-7

Development of childhood asthma: results from the BAMSE study
Melen E, Nordvall Sl, Pershagen G, Van Hage-hamsten M, Wickman M
ALLERGY 2002;:180-180

The BAMSE study: Symptoms of asthma in children at four years of age
Melen E, Kull I, Nordvall L, Pershagen G, Tollin L, Wickman M
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2002;109(1):S267-S267

Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children
Melen E, Wickman M, Nordvall Sl, Van Hage-hamsten M, Lindfors A
ALLERGY 2001;56(7):646-52

Causes of severe asthma in preschool children
Melen E, Nordvall L, Von Hage-hamsten M, Wickman M, Lindfors A
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2000;105(1):S80-S80

Molecular cloning of Per a 1 and definition of the cross-reactive Group 1 cockroach allergens
Melen E, Pomes A, Vailes Ld, Arruda Lk, Chapman Md
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1999;103(5):859-64

Risk factors for sensitization to fur pets.
Melen E, Almqvist C, Nordvall L, Van Hage-hamsten M, Wickman M, Lindfors A
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1999;103(1):S120-S120

Novel allergen structures with tandem amino acid repeats derived from German and American cockroach
Pomes A, Melen E, Vailes Ld, Retief Jd, Arruda Lk, Chapman Md
JOURNAL OF BIOLOGICAL CHEMISTRY 1998;273(46):30801-7

Source characterization and molecular structure of cockroach allergens
Chapman Md, Vailes Ld, Arruda Lk, Melen E, Pomes A
REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE 1998;38(10):842-845

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Presentations

In the news from our research group:

  • ERC Starting grant to Erik Melén (see press-release from KI and ERC)
  • A comprehensive review on Lung function development now published, see full paper here
  • Heart-Lung Foundation releases the 2017 Lung report, see TV4 comments by Erik Melén here
  • Anna Gref's thesis defense, May 5th, Samuelssonsalen, KI.
  • Bad air - bad lungs; article series in Dagens Nyheter, DN
  • Gene-environment interaction effects on asthma identified, linking childhood asthma with COPD, please see press-release and full paper
  • Erica Schultz to defend her thesis on air pollution and lung function, December 2, lecture hall Hillarp.
  • BAMSE 24-year follow-up started! See press-release from SÖS and visit BAMSE on Facebook.
  • Maternal smoking strongly linked to DNA methylation profiles in offspring, see story in DN
  • Link to the paper here.