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Christina Hultman

Professor

Organisational affiliation

Department of Medical Epidemiology and Biostatistics (MEB), C8

Department

Department of Medical Epidemiology and Biostatistics (MEB), C8

Education

  • 1996 PhD, Clinical Psychology. Department of Psychology, Uppsala University
  • 2002 Associate professor (docent) in Medical Psychology, Departmant of Neuroscience, Uppsala University
  • 2007 Associate professor in psychiatric epidemiology, Karolinska Institutet

Research description

Our research is primarily concerned with possible aetiological role of prenatal risk factors and non-optimal conditions around birth in schizophrenia and other severe psychiatric diseases like affective psychosis, reactive psychosis, infantile autism, anorexia nervosa and ADHD. In a series of clinical case-control studies and population-based studies based on Swedish national registers, we have demonstrated an increased risk for schizophrenia among boys who were small-for-gestational-age or had low ponderal index and maternal bleeding in late pregnancy. The mechanism remains unknown, but ischaemic brain damage secondary to fetal malnutrition and longterm fetal asphyxia is one possibility. We have also found perinatal risk factors related to anorexia nervosa and an increased risk for infantile autism among children born with a small weight for gestational age. To further examine the role of prenatal factors for schizophrenia, our research team has now undertaken a study that examine fetal growth and complications around birth in monozygotic and dizygotic twins discordant for schizophrenia. Another area of interest is adverse pregnancy outcome among parents with psychiatric disorders and we have recently shown an increased risk of low birth weight and stillbirth among high-risk offspring to schizophrenic mothers.

Future projects

The 'fetal growth hypothesis' for schizophrenia will be further tested to disentangle fetal environmental hazards, maternal life style/social disadvantage and genetic liability. For this purpose our research group uses information from the Medical Birth Register, the Inpatient Register and the Twin Register, unit medical records, and interviews, to carry out nation-wide epidemiological studies. A separate, but related issue is to improve our understanding of how healthy co-twins and siblings to persons with schizophrenia perceive and cope with increased familiar risks and view ethically important aspects of research participation.

Current supervision of PhD students

Publications

Aspects of emotional functioning following oesophageal cancer surgery in a population-based cohort study
Hellstadius Y, Lagergren P, Lagergren J, Johar A, Hultman Cm, Wikman A
Psycho-oncology 2015;24(1):47-53

Cognition and autonomic function in schizophrenia: inferior cognitive test performance in electrodermal and niacin skin flush non-responders
Nilsson Bm, Holm G, Hultman Cm, Ekselius L
European psychiatry : the journal of the Association of European Psychiatrists 2015;30(1):8-13

Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use
Clark Sl, Aberg Ka, Nerella S, Kumar G, Mcclay Jl, Chen W, et al
Alcoholism, clinical and experimental research 2015;39(8):1396-405

Increased risk for psychiatric disorders immediately before and after cancer diagnosis: A nationwide matched cohort study in Sweden
Lu D, Andersson Tm, Fall K, Hultman Cm, Czene K, Valdimarsdottir U, et al
Psychoneuroendocrinology 2015;61():50-

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder
Maier R, Moser G, Chen Gb, Ripke S, Cross-disorder Working Group Of The Psychiatric Genomics Consortium, Coryell W, et al
American journal of human genetics 2015;96(2):283-94

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia
Ruderfer Dm, Lim Et, Genovese G, Moran Jl, Hultman Cm, Sullivan Pf, et al
European journal of human genetics : EJHG 2015;23(4):555-7

Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study
Arnberg Fk, Gudmundsdottir R, Butwicka A, Fang F, Lichtenstein P, Hultman Cm, et al
The lancet. Psychiatry 2015;2(9):817-24

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Network And Pathway Analysis Subgroup Of Psychiatric Genomics Consortium
Nature neuroscience 2015;18(2):199-209

Refinement of schizophrenia GWAS loci using methylome-wide association data
Kumar G, Clark Sl, Mcclay Jl, Shabalin Aa, Adkins De, Xie L, et al
Human genetics 2015;134(1):77-87

Registration and definitions of mental disorders in Swedish survivors of the 2004 southeast Asia tsunami--Authors' response
Arnberg Fk, Hultman Cm, Valdimarsdottir Ua
The lancet. Psychiatry 2015;2(11):962-3

The increasing prevalence of reported diagnoses of childhood psychiatric disorders: a descriptive multinational comparison
Atladottir Ho, Gyllenberg D, Langridge A, Sandin S, Hansen Sn, Leonard H, et al
European child & adolescent psychiatry 2015;24(2):173-83

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma
Swaminathan B, Thorleifsson G, Joud M, Ali M, Johnsson E, Ajore R, et al
Nature communications 2015;6():7213-

After the flood: resilience among tsunami-afflicted adolescents
Uttervall M, Hultman Cm, Ekerwald H, Lindam A, Lundin T
Nordic journal of psychiatry 2014;68(1):38-43

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility
Li M, Luo Xj, Rietschel M, Lewis Cm, Mattheisen M, Muller-myhsok B, et al
Molecular psychiatry 2014;19(4):452-61

A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
Mcclay Jl, Aberg Ka, Clark Sl, Nerella S, Kumar G, Xie Ly, et al
Human molecular genetics 2014;23(5):1175-85

An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
Morris Dw, Pearson Rd, Cormican P, Kenny Em, O'dushlaine Ct, Perreault Lp, et al
Human molecular genetics 2014;23(12):3316-26

A polygenic burden of rare disruptive mutations in schizophrenia
Purcell Sm, Moran Jl, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al
Nature 2014;506(7487):185-90

Autism and Mental Retardation Among Offspring Born After In Vitro Fertilization EDITORIAL COMMENT
Sandin S, Nygren Kg, Iliadou A, Hultman Cm, Reichenberg A
OBSTETRICAL & GYNECOLOGICAL SURVEY 2014;69(1):1-2

Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group Of The Psychiatric Genomics Consortium
Nature 2014;511(7510):421-7

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese G, Kahler Ak, Handsaker Re, Lindberg J, Rose Sa, Bakhoum Sf, et al
The New England journal of medicine 2014;371(26):2477-87

CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
Rees E, Walters Jt, Chambert Kd, O'dushlaine C, Szatkiewicz J, Richards Al, et al
Human molecular genetics 2014;23(6):1669-76

Copy number variation in schizophrenia in Sweden
Szatkiewicz Jp, O'dushlaine C, Chen G, Chambert K, Moran Jl, Neale Bm, et al
Molecular psychiatry 2014;19(7):762-73

Dimensions of psychotic experiences among women in the general population
Therman S, Suvisaari J, Hultman Cm
International journal of methods in psychiatric research 2014;23(1):62-8

Enhanced neurocognitive functioning and positive temperament in twins discordant for bipolar disorder
Higier Rg, Jimenez Am, Hultman Cm, Borg J, Roman C, Kizling I, et al
The American journal of psychiatry 2014;171(11):1191-8

Evidence that duplications of 22q11.2 protect against schizophrenia
Rees E, Kirov G, Sanders A, Walters Jt, Chambert Kd, Shi J, et al
Molecular psychiatry 2014;19(1):37-40

Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder
Hart Ab, Gamazon Er, Engelhardt Be, Sklar P, Kahler Ak, Hultman Cm, et al
Proceedings of the National Academy of Sciences of the United States of America 2014;111(16):5968-73

Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults
Aberg Ka, Mcclay Jl, Nerella S, Clark S, Kumar G, Chen W, et al
JAMA psychiatry 2014;71(3):255-64

Most genetic risk for autism resides with common variation
Gaugler T, Klei L, Sanders Sj, Bodea Ca, Goldberg Ap, Lee Ab, et al
Nature genetics 2014;46(8):881-5

Multiple sclerosis and psychiatric disorders: comorbidity and sibling risk in a nationwide Swedish cohort
Johansson V, Lundholm C, Hillert J, Masterman T, Lichtenstein P, Landen M, et al
Multiple sclerosis (Houndmills, Basingstoke, England) 2014;20(14):1881-91

Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress
Class Qa, Abel Km, Khashan As, Rickert Me, Dalman C, Larsson H, et al
Psychological medicine 2014;44(1):71-84

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Gusev A, Lee Sh, Trynka G, Finucane H, Vilhjalmsson Bj, Xu H, et al
American journal of human genetics 2014;95(5):535-52

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Ruderfer Dm, Fanous Ah, Ripke S, Mcquillin A, Amdur Rl, Schizophrenia Working Group Of Psychiatric Genomics Consortium, et al
Molecular psychiatry 2014;19(9):1017-24

Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia
Mulle Jg, Pulver Ae, Mcgrath Ja, Wolyniec Ps, Dodd Af, Cutler Dj, et al
Biological psychiatry 2014;75(5):371-7

Specific glial functions contribute to schizophrenia susceptibility
Goudriaan A, De Leeuw C, Ripke S, Hultman Cm, Sklar P, Sullivan Pf, et al
Schizophrenia bulletin 2014;40(4):925-35

Synaptic, transcriptional and chromatin genes disrupted in autism
De Rubeis S, He X, Goldberg Ap, Poultney Cs, Samocha K, Cicek Ae, et al
Nature 2014;515(7526):209-15

The familial risk of autism
Sandin S, Lichtenstein P, Kuja-halkola R, Larsson H, Hultman Cm, Reichenberg A
JAMA 2014;311(17):1770-7

A comprehensive family-based replication study of schizophrenia genes
Aberg Ka, Liu Y, Bukszar J, Mcclay Jl, Khachane An, Andreassen Oa, et al
JAMA psychiatry 2013;70(6):573-81

A nationwide study of the association between celiac disease and the risk of autistic spectrum disorders
Ludvigsson Jf, Reichenberg A, Hultman Cm, Murray Ja
JAMA psychiatry 2013;70(11):1224-30

Are prenatal, obstetric, and infant complications associated with postpartum psychosis among women with pre-conception psychiatric hospitalisations?
Hellerstedt Wl, Phelan Sm, Cnattingius S, Hultman Cm, Harlow Bl
BJOG : an international journal of obstetrics and gynaecology 2013;120(4):446-55

Autism and mental retardation among offspring born after in vitro fertilization
Sandin S, Nygren Kg, Iliadou A, Hultman Cm, Reichenberg A
JAMA 2013;310(1):75-84

Autism in children born after in vitro fertilization--reply
Sandin S, Hultman C, Reichenberg A
JAMA 2013;310(19):2101-

Autism risk across generations: a population-based study of advancing grandpaternal and paternal age
Frans Em, Sandin S, Reichenberg A, Langstrom N, Lichtenstein P, Mcgrath Jj, et al
JAMA psychiatry 2013;70(5):516-21

Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia
Bloom Rj, Kahler Ak, Collins Al, Chen G, Cannon Td, Hultman C, et al
Schizophrenia research 2013;146(1-3):289-90

Detecting large copy number variants using exome genotyping arrays in a large Swedish schizophrenia sample
Szatkiewicz Jp, Neale Bm, O'dushlaine C, Fromer M, Goldstein Ji, Moran Jl, et al
Molecular psychiatry 2013;18(11):1178-84

Fifteen years after a ferry disaster: clinical interviews and survivors' self-assessment of their experience
Arnberg Fk, Hultman Cm, Michel Po, Lundin T
European journal of psychotraumatology 2013;4():-

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-disorder Group Of The Psychiatric Genomics Consortium, Lee Sh, Ripke S, Neale Bm, Faraone Sv, Purcell Sm, et al
Nature genetics 2013;45(9):984-94

Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Ripke S, O'dushlaine C, Chambert K, Moran Jl, Kahler Ak, Akterin S, et al
Nature genetics 2013;45(10):1150-9

Implication of a rare deletion at distal 16p11.2 in schizophrenia
Guha S, Rees E, Darvasi A, Ivanov D, Ikeda M, Bergen Se, et al
JAMA psychiatry 2013;70(3):253-60

Initiating therapy with antidepressants after discontinuation of hormone therapy
Citarella A, Andersen M, Sundstrom A, Bardage C, Hultman Cm, Kieler H
Menopause (New York, N.Y.) 2013;20(2):146-51

Mental illness, suicide and creativity: 40-year prospective total population study
Kyaga S, Landen M, Boman M, Hultman Cm, Langstrom N, Lichtenstein P
Journal of psychiatric research 2013;47(1):83-90

MethylPCA: a toolkit to control for confounders in methylome-wide association studies
Chen W, Gao G, Nerella S, Hultman Cm, Magnusson Pk, Sullivan Pf, et al
BMC bioinformatics 2013;14():74-

Microparticles and microscopic structures in three fractions of fresh cerebrospinal fluid in schizophrenia: case report of twins
Mobarrez F, Nybom R, Johansson V, Hultman Cm, Wallen H, Landen M, et al
Schizophrenia research 2013;143(1):192-7

Mosaic copy number variation in schizophrenia
Ruderfer Dm, Chambert K, Moran J, Talkowski M, Chen Es, Gigek C, et al
European journal of human genetics : EJHG 2013;21(9):1007-11

Schizophrenia susceptibility and age of diagnosis--a frailty approach
Svensson E, Rogvin M, Hultman Cm, Reichborn-kjennerud T, Sandin S, Moger Ta
Schizophrenia research 2013;147(1):140-6

Social class, social mobility and risk of psychiatric disorder--a population-based longitudinal study
Tiikkaja S, Sandin S, Malki N, Modin B, Sparen P, Hultman Cm
PloS one 2013;8(11):e77975-

The International Collaboration for Autism Registry Epidemiology (iCARE): multinational registry-based investigations of autism risk factors and trends
Schendel De, Bresnahan M, Carter Kw, Francis Rw, Gissler M, Gronborg Tk, et al
Journal of autism and developmental disorders 2013;43(11):2650-63

Utilizing twins as controls for non-twin case-materials in genome wide association studies
Ganna A, Ortega-alonso A, Havulinna A, Salomaa V, Kaprio J, Pedersen Nl, et al
PloS one 2013;8(12):e83101-

Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis
Sandin S, Hultman Cm, Kolevzon A, Gross R, Maccabe Jh, Reichenberg A
Journal of the American Academy of Child and Adolescent Psychiatry 2012;51(5):477-486.e1

Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth
Fromer M, Moran Jl, Chambert K, Banks E, Bergen Se, Ruderfer Dm, et al
American journal of human genetics 2012;91(4):597-607

Exome sequencing and the genetic basis of complex traits
Kiezun A, Garimella K, Do R, Stitziel No, Neale Bm, Mclaren Pj, et al
Nature genetics 2012;44(6):623-30

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies
Pasaniuc B, Rohland N, Mclaren Pj, Garimella K, Zaitlen N, Li H, et al
Nature genetics 2012;44(6):631-5

Familial aggregation of schizophrenia: the moderating effect of age at onset, parental immigration, paternal age and season of birth
Svensson Ac, Lichtenstein P, Sandin S, Oberg S, Sullivan Pf, Hultman Cm
Scandinavian journal of public health 2012;40(1):43-50

Family history of schizophrenia and bipolar disorder as risk factors for autism
Sullivan Pf, Magnusson C, Reichenberg A, Boman M, Dalman C, Davidson M, et al
Archives of general psychiatry 2012;69(11):1099-1103

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia
Lips Es, Cornelisse Ln, Toonen Rf, Min Jl, Hultman Cm, International Schizophrenia Consortium, et al
Molecular psychiatry 2012;17(10):996-1006

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
Bergen Se, O'dushlaine Ct, Ripke S, Lee Ph, Ruderfer Dm, Akterin S, et al
Molecular psychiatry 2012;17(9):880-6

MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples
Aberg Ka, Mcclay Jl, Nerella S, Xie Ly, Clark Sl, Hudson Ad, et al
Epigenomics 2012;4(6):605-21

Microscopic particles in two fractions of fresh cerebrospinal fluid in twins with schizophrenia or bipolar disorder and in healthy controls
Johansson V, Nybom R, Wetterberg L, Hultman Cm, Cannon Td, Johansson Ag, et al
PloS one 2012;7(9):e45994-

Perinatal risk factors in offenders with severe personality disorder: a population-based investigation
Fazel S, Bakiyeva L, Cnattingius S, Grann M, Hultman Cm, Lichtenstein P, et al
Journal of personality disorders 2012;26(5):737-50

Poor school performance in offspring of patients with schizophrenia: what are the mechanisms?
Jundong J, Kuja-halkola R, Hultman C, Langstrom N, D'onofrio Bm, Lichtenstein P
Psychological medicine 2012;42(1):111-23

Preterm Birth and Psychiatric Disorders in Young Adult Life
Nosarti C, Reichenberg A, Murray Rm, Cnattingius S, Lambe Mp, Yin L, et al
ARCHIVES OF GENERAL PSYCHIATRY 2012;69(6):610-617

Social support moderates posttraumatic stress and general distress after disaster
Arnberg Fk, Hultman Cm, Michel Po, Lundin T
Journal of traumatic stress 2012;25(6):721-7

The Promises and Pitfalls of Genoeconomics
Swedish Large Schizophrenia Study, Wisconsin Longitudinal Study, Framingham Heart Study, Swedish Twin Registry, Age Gene Environm, Benjamin Dj, et al
ANNUAL REVIEW OF ECONOMICS, VOL 4 2012;:627-+

zCall: a rare variant caller for array-based genotyping: genetics and population analysis
Goldstein Ji, Crenshaw A, Carey J, Grant Gb, Maguire J, Fromer M, et al
Bioinformatics (Oxford, England) 2012;28(19):2543-5

Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective
Frans Em, Mcgrath Jj, Sandin S, Lichtenstein P, Reichenberg A, Langstrom N, et al
Schizophrenia research 2011;133(1-3):120-4

Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies
Hultman Cm, Sandin S, Levine Sz, Lichtenstein P, Reichenberg A
Molecular psychiatry 2011;16(12):1203-12

Creativity and mental disorder: family study of 300,000 people with severe mental disorder
Kyaga S, Lichtenstein P, Boman M, Hultman C, Langstrom N, Landen M
The British journal of psychiatry : the journal of mental science 2011;199(5):373-9

Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
Williams Hj, Norton N, Dwyer S, Moskvina V, Nikolov I, Carroll L, et al
Molecular psychiatry 2011;16(4):429-41

Genome-wide association study identifies five new schizophrenia loci
Schizophrenia Psychiatric Genome-wide Association Study (gwas) Consortium
Nature genetics 2011;43(10):969-76

GENOME-WIDE ASSOCIATION STUDY OF STRUCTURAL MRI PHENOTYPES IN A SWEDISH TWIN COHORT
Lutkenhoff Es, Sun D, Hultman Cm, Lichtenstein P, Cannon T
SCHIZOPHRENIA BULLETIN 2011;:171-171

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
Chen X, Lee G, Maher Bs, Fanous Ah, Chen J, Zhao Z, et al
Molecular psychiatry 2011;16(11):1117-29

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Psychiatric Gwas Consortium Bipolar Disorder Working Group
Nature genetics 2011;43(10):977-83

NEUROCOGNITIVE FUNCTIONING IN TWINS DISCORDANT FOR SCHIZOPHRENIA AND BIPOLAR DISORDER
Higier Rg, Hultman C, Borg J, Kizling I, Cannon T
SCHIZOPHRENIA BULLETIN 2011;:210-210

Prolonged grief among traumatically bereaved relatives exposed and not exposed to a tsunami
Johannesson Kb, Lundin T, Hultman Cm, Frojd T, Michel Po
Journal of traumatic stress 2011;24(4):456-64

The genetic structure of the Swedish population
Humphreys K, Grankvist A, Leu M, Hall P, Liu J, Ripatti S, et al
PloS one 2011;6(8):e22547-

Traumatic bereavement, acute dissociation, and posttraumatic stress: 14 years after the MS Estonia disaster
Arnberg Fk, Eriksson Ng, Hultman Cm, Lundin T
Journal of traumatic stress 2011;24(2):183-90

Tsunami-affected Scandinavian tourists: disaster exposure and post-traumatic stress symptoms
Heir T, Rosendal S, Bergh-johannesson K, Michel Po, Mortensen El, Weisaeth L, et al
Nordic journal of psychiatry 2011;65(1):9-15

Tsunami-exposed tourist survivors: signs of recovery in a 3-year perspective
Johannesson Kb, Lundin T, Frojd T, Hultman Cm, Michel Po
The Journal of nervous and mental disease 2011;199(3):162-9

Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden
Sellgren C, Landen M, Lichtenstein P, Hultman Cm, Langstrom N
Acta psychiatrica Scandinavica 2011;124(6):447-53

A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement
D'onofrio Bm, Singh Al, Iliadou A, Lambe M, Hultman Cm, Neiderhiser Jm, et al
Child development 2010;81(1):80-100

Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population
Hedelin M, Lof M, Olsson M, Lewander T, Nilsson B, Hultman Cm, et al
BMC psychiatry 2010;10():38-

Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study
Maccabe Jh, Lambe Mp, Cnattingius S, Sham Pc, David As, Reichenberg A, et al
The British journal of psychiatry : the journal of mental science 2010;196(2):109-15

Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden
D'onofrio Bm, Singh Al, Iliadou A, Lambe M, Hultman Cm, Grann M, et al
Archives of general psychiatry 2010;67(5):529-38

Familial factors confound the association between maternal smoking during pregnancy and young adult offspring overweight
Iliadou An, Koupil I, Villamor E, Altman D, Hultman C, Langstrom N, et al
International journal of epidemiology 2010;39(5):1193-202

Genetic differences between five European populations
Moskvina V, Smith M, Ivanov D, Blackwood D, Stclair D, Hultman C, et al
Human heredity 2010;70(2):141-9

Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspring
Lundberg F, Cnattingius S, D'onofrio B, Altman D, Lambe M, Hultman C, et al
Paediatric and perinatal epidemiology 2010;24(1):79-87

Parental autoimmune diseases associated with autism spectrum disorders in offspring
Keil A, Daniels Jl, Forssen U, Hultman C, Cnattingius S, Soderberg Kc, et al
Epidemiology (Cambridge, Mass.) 2010;21(6):805-8

Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies
Lundstrom S, Haworth Cm, Carlstrom E, Gillberg C, Mill J, Rastam M, et al
Journal of child psychology and psychiatry, and allied disciplines 2010;51(7):850-6

Can association between preterm birth and autism be explained by maternal or neonatal morbidity?
Buchmayer S, Johansson S, Johansson A, Hultman Cm, Sparen P, Cnattingius S
Pediatrics 2009;124(5):e817-25

Combining data from 2 nested case-control studies of overlapping cohorts to improve efficiency
Salim A, Hultman C, Sparen P, Reilly M
Biostatistics (Oxford, England) 2009;10(1):70-9

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
Lichtenstein P, Yip Bh, Bjork C, Pawitan Y, Cannon Td, Sullivan Pf, et al
Lancet (London, England) 2009;373(9659):234-9

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
International Schizophrenia Consortium, Purcell Sm, Wray Nr, Stone Jl, Visscher Pm, O'donovan Mc, et al
Nature 2009;460(7256):748-52

Ethical Issues in Cancer Register Follow-Up of Hormone Treatment in Adolescence
Hultman Cm, Lindgren Ac, Hansson Mg, Carlstedt-duke J, Ritzen M, Persson I, et al
PUBLIC HEALTH ETHICS 2009;2(1):30-36

Impact of exposure to trauma on posttraumatic stress disorder symptomatology in Swedish tourist tsunami survivors
Johannesson Kb, Michel Po, Hultman Cm, Lindam A, Arnberg F, Lundin T
The Journal of nervous and mental disease 2009;197(5):316-23

Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families
Svensson Ac, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman Cm, et al
American journal of epidemiology 2009;170(11):1365-72

Prenatal ultrasound exposure and children's school performance at age 15-16: follow-up of a randomized controlled trial
Stalberg K, Axelsson O, Haglund B, Hultman Cm, Lambe M, Kieler H
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2009;34(3):297-303

Psychotic illness in first-time mothers with no previous psychiatric hospitalizations: a population-based study
Valdimarsdottir U, Hultman Cm, Harlow B, Cnattingius S, Sparen P
PLoS medicine 2009;6(2):e13-

Risk of suicide among operated and non-operated patients hospitalised for peptic ulcers
Bahmanyar S, Sparen P, Rutz Em, Hultman Cm
Journal of epidemiology and community health 2009;63(12):1016-21

Social problem-solving in high-functioning schizophrenia: specific deficits in sending skills
Vaskinn A, Sundet K, Hultman Cm, Friis S, Andreassen Oa
Psychiatry research 2009;165(3):215-23

Svensson et al. respond to "Maternal genes and environment in preterm birth"
Svensson Ac, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman Cm, et al
American journal of epidemiology 2009;170(11):1386-7

TEMPERAMENT AS A DISCRIMINATING MARKER OF GENETIC LIABILITY FOR SCHIZOPHRENIA AND BIPOLAR DISORDER
Jimenez Am, Lieberman Md, Hultman Cm, Cannon Td
SCHIZOPHRENIA BULLETIN 2009;:111-111

Test-retest stability of the oral niacin test and electrodermal activity in patients with schizophrenia
Nilsson Bm, Hultman Cm, Ekselius L
Prostaglandins, leukotrienes, and essential fatty acids 2009;81(5-6):367-72

The effect of traumatic bereavement on tsunami-exposed survivors
Johannesson Kb, Lundin T, Hultman Cm, Lindam A, Dyster-aas J, Arnberg F, et al
Journal of traumatic stress 2009;22(6):497-504

Advancing paternal age and bipolar disorder
Frans Em, Sandin S, Reichenberg A, Lichtenstein P, Langstrom N, Hultman Cm
Archives of general psychiatry 2008;65(9):1034-40

Covariance component models for multivariate binary traits in family data analysis
Yip Bh, Bjork C, Lichtenstein P, Hultman Cm, Pawitan Y
Statistics in medicine 2008;27(7):1086-105

Maternal Smoking During Pregnancy and Offspring Criminal Convictions: Disconfirming a Causal Inference
D'onofrio Bm, Singh Al, Iliadou A, Lambe M, Hultman Cm, Grann M, et al
BEHAVIOR GENETICS 2008;38(6):620-620

Parental psychiatric disorders associated with autism spectrum disorders in the offspring
Daniels Jl, Forssen U, Hultman Cm, Cnattingius S, Savitz Da, Feychting M, et al
Pediatrics 2008;121(5):e1357-62

Rare chromosomal deletions and duplications increase risk of schizophrenia
International Schizophrenia Consortium
Nature 2008;455(7210):237-41

Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death
Nilsson E, Hultman Cm, Cnattingius S, Olausson Po, Bjork C, Lichtenstein P
The British journal of psychiatry : the journal of mental science 2008;193(4):311-5

Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study
Maccabe Jh, Lambe Mp, Cnattingius S, Torrang A, Bjork C, Sham Pc, et al
Psychological medicine 2008;38(8):1133-40

Suicide among patients with amyotrophic lateral sclerosis
Fang F, Valdimarsdottir U, Furst Cj, Hultman C, Fall K, Sparen P, et al
Brain : a journal of neurology 2008;131(Pt 10):2729-33

Video-based assessment of interpersonal problem solving skills in patients with schizophrenia, their siblings and non-psychiatric controls
Stalberg G, Lichtenstein P, Sandin S, Hultman Cm
Scandinavian journal of psychology 2008;49(1):77-82

Adverse pregnancy outcomes in mothers with affective psychosis
Maccabe Jh, Martinsson L, Lichtenstein P, Nilsson E, Cnattingius S, Murray Rm, et al
Bipolar disorders 2007;9(3):305-9

Adverse pregnancy outcomes in mothers with schizophrenia: maternal and paternal influences
Hultman Cm, Lichtenstein R, Cnattingius S, Nilsson E
EARLY HUMAN DEVELOPMENT 2007;:S36-S37

Birth weight and attention-deficit/hyperactivity symptoms in childhood and early adolescence: a prospective Swedish twin study
Hultman Cm, Torrang A, Tuvblad C, Cnattingius S, Larsson Jo, Lichtenstein P
Journal of the American Academy of Child and Adolescent Psychiatry 2007;46(3):370-7

Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective
Svensson Ac, Lichtenstein P, Sandin S, Hultman Cm
Schizophrenia research 2007;91(1-3):238-45

Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior prepregnancy or prenatal psychiatric hospitalizations
Harlow Bl, Vitonis Af, Sparen P, Cnattingius S, Joffe H, Hultman Cm
Archives of general psychiatry 2007;64(1):42-8

Prenatal ultrasound scanning and the risk of schizophrenia and other psychoses
Stalberg K, Haglund B, Axelsson O, Cnattingius S, Hultman Cm, Kieler H
Epidemiology (Cambridge, Mass.) 2007;18(5):577-82

Academic achievement at age 16 has contrasting effects on risk of later bipolar disorder and schizophrenia
Maccabe Jh, Lambe M, Cnattingius S, Torrang A, Bjork C, Sham Pc, et al
SCHIZOPHRENIA RESEARCH 2006;:4-5

Critical parameters for the genetics of schizophrenia
Lichtenstein P, Bjork C, Hultman Cm, Scolnick E, Sullivan Pf
SCHIZOPHRENIA RESEARCH 2006;:198-198

Evidence of shared genetic etiology in schizophrenia and bipolar disorder: A study of first and second degree relatives in Sweden
Lichtenstein P, Yip B, Bjork C, Pawitan Y, Hultman C
SCHIZOPHRENIA RESEARCH 2006;:3-3

First episode psychosis in first-time mothers
Valdimarsdottir U, Hultman Cm, Harlow B, Cnattingius S, Sparen P
SCHIZOPHRENIA RESEARCH 2006;:238-238

Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior pre-pregnancy or prenatal psychiatric hospitalizations
Harlow Bl, Vitonis Af, Joffe H, Sparen P, Cnattingius S, Hultman Cm
SCHIZOPHRENIA RESEARCH 2006;:186-186

Maternal smoking during pregnancy and school performance at age 15
Lambe M, Hultman C, Torrang A, Maccabe J, Cnattingius S
Epidemiology (Cambridge, Mass.) 2006;17(5):524-30

Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls
Nilsson Bm, Hultman Cm, Wiesel Fa
Prostaglandins, leukotrienes, and essential fatty acids 2006;74(5):339-46

Recurrence risks for schizophrenia in a Swedish national cohort
Lichtenstein P, Bjork C, Hultman Cm, Scolnick E, Sklar P, Sullivan Pf
Psychological medicine 2006;36(10):1417-25

Schizophrenia and low birth weight - Maternal, paternal and genetic influences
Nilsson E, Hultman Cm, Cnattingius S, Olausson Po, Lichtenstein P
SCHIZOPHRENIA RESEARCH 2006;:184-185

Critical parameters for the genetics of schizophrenia
Lichtenstein P, Bjork C, Hultman C, Sullivan P
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 2005;138B(1):19-19

Fetal growth restriction and schizophrenia - A Swedish twin study
Nilsson E, Stalberg G, Lichtenstein P, Cnattingius S, Olausson Po, Hultman Cm
SCHIZOPHRENIA BULLETIN 2005;31(2):234-234

Fetal growth restriction and schizophrenia: a Swedish twin study
Nilsson E, Stalberg G, Lichtenstein P, Cnattingius S, Olausson Po, Hultman Cm
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(4):402-8

Schizophrenia and bipolar disorder share a common genetic etiology: A study of 11 million first and second degree relatives in Swedish
Lichtenstein P, Yip B, Bjork C, Pawitan Y, Hultman C
BEHAVIOR GENETICS 2005;35(6):811-811

Schizophrenia and low birth weight - is the association due to common genes or common environments?
Nilsson E, Hultman Cm, Cnattingius S, Olausson Po, Lichtenstein P
BEHAVIOR GENETICS 2005;35(6):816-816

At issue: siblings of patients with schizophrenia: sibling bond, coping patterns, and fear of possible schizophrenia heredity
Stalberg G, Ekerwald H, Hultman Cm
Schizophrenia bulletin 2004;30(2):445-58

Autism--prenatal insults or an epiphenomenon of a strongly genetic disorder?
Hultman Cm, Sparen P
Lancet (London, England) 2004;364(9433):485-7

Elevated risk of pregnancy and delivery complications in births to mothers with affective psychosis
Maccabe Jh, Murray Rm, Hultman Cm
SCHIZOPHRENIA RESEARCH 2004;67(1):44-44

Siblings of patients with schizophrenia: Sibling bond, coping patterns and fear of possible heredity
Stalberg G, Ekerwald H, Dverre C, Hultman Cm
SCHIZOPHRENIA RESEARCH 2004;67(1):225-225

Web-based screening of psychotic symptoms: Possibilities and problems
Hultman Cm, Stalberg G, Ekman A, Litton Je, Magnusson C
SCHIZOPHRENIA RESEARCH 2004;67(1):82-82

Interpersonal problem solving skills and electrodermal activity in schizophrenia
Hultman C, Stalberg G, Donahoe Cp
SCHIZOPHRENIA RESEARCH 2003;60(1):251-252

School achievements and schizophrenia: a case-control study
Helling I, Ohman A, Hultman Cm
Acta psychiatrica Scandinavica 2003;108(5):381-6

Sibling bond and coping with heredity in schizophrenia
Stalberg G, Ekerwald H, Hultman Cm
SCHIZOPHRENIA RESEARCH 2003;60(1):184-184

Fetal growth impairment - the relevance to psychiatric outcome
Hultman Cm, Cnattingius S, Sparen R, Lichtenstein P
EUROPEAN PSYCHIATRY 2002;:11S-11S

Perinatal risk factors for infantile autism
Hultman Cm, Sparen P, Cnattingius S
Epidemiology (Cambridge, Mass.) 2002;13(4):417-23

Women with schizophrenia: pregnancy outcome and infant death among their offspring
Nilsson E, Lichtenstein P, Cnattingius S, Murray Rm, Hultman Cm
Schizophrenia research 2002;58(2-3):221-9

Still birth, infant death, preterm birth and low birth weight among offspring of women with schizophrenia
Hultman Cm, Nilsson E, Cnattingius S, Murray Rm, Lichtenstein P
SCHIZOPHRENIA RESEARCH 2001;49(1-2):33-33

Early risk factors for infantile autism
Hultman Cm, Cnattingius S, Sparen P
INTERNATIONAL JOURNAL OF PSYCHOLOGY 2000;35(3-4):106-106

Interpersonal problem solving skills and electrodermal activity in schizophrenia
Stalberg G, Hultman Cm, Nilsson C
INTERNATIONAL JOURNAL OF PSYCHOLOGY 2000;35(3-4):441-441

Intra-uterine growth and risk of schizophrenia, affective psychosis, reactive psychosis, infantile autism and anorexia nervosa
Hultman Cm, Cnattingius S, Sparen P
SCHIZOPHRENIA RESEARCH 2000;41(1):68-69

School achivements, prenatal factors and age of onset in schizophrenia
Helling Ibm, Hultman Cm, Wieselgren Im, Ohman A
INTERNATIONAL JOURNAL OF PSYCHOLOGY 2000;35(3-4):355-355

Prenatal and perinatal risk factors for psychiatric diseases of early onset - Results are different if seasons are categorised differently - Reply
Hultman Cm
BRITISH MEDICAL JOURNAL 1999;318(7198):1623-1623

Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control study
Hultman Cm, Sparen P, Takei N, Murray Rm, Cnattingius S
BMJ (Clinical research ed.) 1999;318(7181):421-6

School achievements and schizophrenia: A case-control study
Hultman Cm, Helling I, Wieselgren Im, Ohman A
SCHIZOPHRENIA RESEARCH 1999;36(1-3):42-43

Very preterm birth, birth trauma, and the risk of anorexia nervosa among girls
Cnattingius S, Hultman Cm, Dahl M, Sparen P
Archives of general psychiatry 1999;56(7):634-8

Aberrations in intrauterine growth as independent risk factors for schizophrenia
Hultman Cm, Cnattingius S
SCHIZOPHRENIA RESEARCH 1998;29(1-2):15-15

Electrodermal activity and obstetric complications in schizophrenia
Ohman A, Hultman Cm
Journal of abnormal psychology 1998;107(2):228-37

Perinatal characteristics and schizophrenia: electrodermal activity as a mediating link in a vulnerability-stress perspective
Hultman Cm, Ohman A
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(3-4):307-16

Prenatal and neonatal risk factors for schizophrenia
Hultman Cm, Ohman A, Cnattingius S, Wieselgren Im, Lindstrom Lh
The British journal of psychiatry : the journal of mental science 1997;170():128-33

Relationships between social support, social coping and life events in the relapse of schizophrenic patients
Hultman Cm, Wieselgren Im, Ohman A
Scandinavian journal of psychology 1997;38(1):3-13

Electrodermal activity and social network as predictors of outcome of episodes in schizophrenia
Hultman Cm, Ohlund Ls, Wieselgren Im, Ohman A, Ost Lg
Journal of abnormal psychology 1996;105(4):626-36

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