What we do
Immunotherapy
The Applied Immunology group is dedicated to investigation of the pathogenesis of incurable diseases affecting the Central Nervous System /CNS), including chronic Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Alzheimer’s disease and Glioblastoma brain tumors. There are currently no effective therapies for any of these diseases and so our primary aim is to develop new therapies for use in these diseases. Through study of experimental diseases,our ultimate aim is to apply this knowledge to the human clinical situation.
We conduct a strongly interconnected research programme aimed at using knowledge gained from projects in basic science to applications in a clinical setting. These aims can be summarised as:
- Studying the heterogeneity of microglial function in the CNS
- Developing myeloid cell-targeted immunotherapies
- Development of novel immunotherapies using immunoparticles
Another major aim is the training of PhD students and postdoctoral fellows. We contribute to teaching in the undergraduate programs for Allergy, Immunology & Inflammation, Neuroscience and Biomedicine. Students and clinicians are welcome to conduct projects in the laboratory. The research laboratory is located in the Centre for Molecular Medicine (CMM) at the Karolinska Hospital. Within CMM, we collaborate with research groups in rheumatology, immunology, cell biology and other disciplines. We are also engaged in active collaborations with research groups at MTC, Huddinge Hospital and several international institutions.
Research projects
- Personalised myeloid cell therapy for treatment of chronic neuroinflammatory diseases
- Microglial depletion and repopulation treatment of neurodegenerative diseases
- Immunotherapy in neurological diseases using immunoparticles