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Victoria Menendez Benito

Assistant professor

About me

I am Assistant Professor at the department of Bioscience and Nutrition at Karolinska Institute.

I completed my master’s degrees in chemistry and molecular biology at the University of Oviedo in Spain. Following my undergraduate studies, I moved to Sweden and joined the labs of Maria Masucci and Nico Dantuma at the Karolinska Institute. There, I performed my doctoral studies investigating whether failure in the ubiquitin-proteasome system contributes to neurodegerative diseases.

Following my graduation, I completed postdoctoral training in the lab of Jacques Neefjes, at the Netherlands Cancer Institute in Amsterdam, where I studied how cells handle organelles and stable macromolecular complexes during mitosis. Based on the results from these studies, I became interested in mitotic asymmetries, where proteins, membrane compartments, organelles or even DNA are asymmetrically distributed between two daughter cells.

Currently, I am principal investigator on studies on the role of centrosomes in asymmetric cell division.


Main interests:

Asymmetric cell division, centrosome inheritance, cancer, protein quality control, yeast, high-content microscope screening, live-cell imaging


Previous research appointments:

Neefjes lab

van Leeuwen lab

Dantuma lab

Masucci lab


Post-doctoral research fellow, Division of Cell Biology The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands

Ph.D. in Medicine, Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden

M.Sc. in Biochemistry and Molecular Biology, University of Oviedo, Spain

M.Sc. in Organic Chemistry, University of Oviedo, Spain

Research description

Recently, a strong correlation between centrosome age and fate has been reported in a number of asymmetric dividing stem cells. The main goal of our research is to understand how this stereotyped centrosome behavior occurs at the molecular level. We use budding yeast as a model for asymmetric cell division in combination with proteomics, genetics and advanced fluorescent microscopy.


A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin
Svensson Jp, Shukla M, Menendez-benito V, Norman-axelsson U, Audergon P, Sinha I, et al
Genome research 2015;25(6):872-83

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging
Van Deventer S, Menendez-benito V, Van Leeuwen F, Neefjes J
Journal of cell science 2015;128(1):109-17

Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae
Terweij M, Van Welsem T, Van Deventer S, Verzijlbergen Kf, Menendez-benito V, Ontoso D, et al
G3 (Bethesda, Md.) 2013;3(8):1261-72

Spatiotemporal analysis of organelle and macromolecular complex inheritance
Menendez-benito V, Van Deventer Sj, Jimenez-garcia V, Roy-luzarraga M, Van Leeuwen F, Neefjes J
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):175-80

Recombination-induced tag exchange to track old and new proteins
Verzijlbergen Kf, Menendez-benito V, Van Welsem T, Van Deventer Sj, Lindstrom Dl, Ovaa H, et al
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):64-8

Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress
Salomons Fa, Menéndez-benito V, Böttcher C, Mccray Ba, Taylor Jp, Dantuma Np
Molecular and cellular biology 2009;29(7):1774-85

Autophagy in MHC class II presentation: sampling from within
Menéndez-benito V, Neefjes J
Immunity 2007;26(1):1-3

Disease-associated prion protein oligomers inhibit the 26S proteasome
Kristiansen M, Deriziotis P, Dimcheff De, Jackson Gs, Ovaa H, Naumann H, et al
Molecular cell 2007;26(2):175-88

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice
Zaman F, Menendez-benito V, Eriksson E, Chagin As, Takigawa M, Fadeel B, et al
Cancer research 2007;67(20):10078-86

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo
Verdoes M, Florea Bi, Menendez-benito V, Maynard Cj, Witte Md, Van Der Linden Wa, et al
Chemistry & biology 2006;13(11):1217-26

GFP reporter mouse models of UPS proteolytic function
Lindsten K, Menendez-benito V, Masucci Mg, Dantuma Np
FASEB JOURNAL 2006;20(7):1027-author

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system
Menéndez-benito V, Verhoef Lg, Masucci Mg, Dantuma Np
Human molecular genetics 2005;14(19):2787-99

Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates
Menéndez-benito V, Heessen S, Dantuma Np
Methods in enzymology 2005;399():490-511

A transgenic mouse model of the ubiquitin/proteasome system
Lindsten K, Menéndez-benito V, Masucci Mg, Dantuma Np
Nature biotechnology 2003;21(8):897-902

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