Victoria Menendez Benito
I am Assistant Professor at the department of Bioscience and Nutrition at Karolinska Institute.
I completed my master’s degrees in chemistry and molecular biology at the University of Oviedo in Spain. Following my undergraduate studies, I moved to Sweden and joined the labs of Maria Masucci and Nico Dantuma at the Karolinska Institute. There, I performed my doctoral studies investigating whether failure in the ubiquitin-proteasome system contributes to neurodegerative diseases.
Following my graduation, I completed postdoctoral training in the lab of Jacques Neefjes, at the Netherlands Cancer Institute in Amsterdam, where I studied how cells handle organelles and stable macromolecular complexes during mitosis. Based on the results from these studies, I became interested in mitotic asymmetries, where proteins, membrane compartments, organelles or even DNA are asymmetrically distributed between two daughter cells.
Currently, I am principal investigator on studies on the role of centrosomes in asymmetric cell division.
Asymmetric cell division, centrosome inheritance, cancer, protein quality control, yeast, high-content microscope screening, live-cell imaging
Previous research appointments:
Post-doctoral research fellow, Division of Cell Biology The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands
Ph.D. in Medicine, Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden
M.Sc. in Biochemistry and Molecular Biology, University of Oviedo, Spain
M.Sc. in Organic Chemistry, University of Oviedo, Spain
Recently, a strong correlation between centrosome age and fate has been reported in a number of asymmetric dividing stem cells. The main goal of our research is to understand how this stereotyped centrosome behavior occurs at the molecular level. We use budding yeast as a model for asymmetric cell division in combination with proteomics, genetics and advanced fluorescent microscopy.
GFP reporter mouse models of UPS proteolytic function
FASEB JOURNAL 2006;20(7):1027-author
Endoplasmic reticulum stress compromises the ubiquitin-proteasome system
Human molecular genetics 2005;14(19):2787-99
Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates
Methods in enzymology 2005;399():490-511
A transgenic mouse model of the ubiquitin/proteasome system
Nature biotechnology 2003;21(8):897-902