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Stephan Meinke

Associated

Visiting address : M 54, Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm, Sweden
Postal address : Department of Medicine, Huddinge (MedH), H7, Unit for Hematology, M 54, Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm, Sweden
Delivery address : M 54, Karolinska Universitetssjukhuset Huddinge 141 86 Srockholm, Sweden

About me

I am a project researcher at the department of Clinical Immunology and Transfusion Medicine at Karolinska University Hospital and associated with the group of Petter Höglund at HERM.

Education

  • 2005 Diploma in Biochemistry, University of Hamburg, Germany
  • 2010 PhD in biology, Heidelberg University, Germany, thesis title "Regulation of human lymphocytes by SLAM-related receptors", supervisor Carsten Watzl

Research description

My research is related to transfusion immunology with a focus on platelet transfusions. I investigate ways to improve platelet transfusions for patients with anti-platelet antibodies.

 

Selected publications

Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies.
Meinke S, Sandgren P, Mörtberg A, Karlström C, Kadri N, Wikman A, et al
Transfusion 2016 Feb;56(2):370-82; quiz 369

Sensitive detection of platelet-specific antibodies with a modified MAIPA using biotinylated antibodies and streptavidin-coated beads.
Mörtberg A, Meinke S, Berg P, Killie M, Kjeldsen-Kragh J, Järås K, et al
J. Immunol. Methods 2016 Jul;434():9-15

Targets for Ibrutinib Beyond B Cell Malignancies.
Berglöf A, Hamasy A, Meinke S, Palma M, Krstic A, Månsson R, et al
Scand. J. Immunol. 2015 Sep;82(3):208-17

Random aggregates in newly produced platelet units are associated with platelet activation and release of the immunomodulatory factors sCD40L and RANTES.
Sandgren P, Meinke S, Eckert E, Douagi I, Wikman A, Höglund P
Transfusion 2014 Mar;54(3):602-12

NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation.
Meinke S, Watzl C
Front Immunol 2013 ;4():3

Regulation of NK cell activity by 2B4, NTB-A and CRACC.
Claus M, Meinke S, Bhat R, Watzl C
Front. Biosci. 2008 Jan;13():956-65

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