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Rainer Heuchel

Senior forskare

Visiting address : Clintec, enh f kirurgi, Kliniskt ForskningsCentrum, Novum, plan 4, Karolinska Universitetssjukhuset Huddinge, Sweden
Postal address : Department of Clinical Science, Intervention and Technology (CLINTEC), H9, x, Clintec, enh f kirurgi, Kliniskt ForskningsCentrum, Novum, plan 4, Karolinska Universitetssjukhuset Huddinge, 141 86 Stockholm, Sweden
Delivery address : , Sweden


A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer
Omazic B, Ayoglu B, Löhr M, Segersvärd R, Verbeke C, Magalhaes I, et al
Journal of immunotherapy (Hagerstown, Md. : 1997) 2017;():-

Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics
Lindahl A, Heuchel R, Forshed J, Lehtiö J, Löhr M, Nordström A
Metabolomics : Official journal of the Metabolomic Society 2017;13(5):61-

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
Hessmann E, Patzak Ms, Klein L, Chen N, Kari V, Ramu I, et al
Gut 2017;():-

Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination
Valentini D, Rao M, Rane L, Rahman S, Axelsson-robertson R, Heuchel R, et al
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017;56():140-154

Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-β signaling
Li X, Nania S, Fejzibegovic N, Moro Cf, Klopp-schulze L, Verbeke C, et al
Biochimica et biophysica acta 2016;1862(9):1839-46

Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification
Fernández Moro C, Fernandez-woodbridge A, Alistair D'souza M, Zhang Q, Bozoky B, Kandaswamy Sv, et al
PloS one 2016;11(11):e0166067-

Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla
Haraldsson E, Swahn F, Verbeke C, Mattsson Js, Enochsson L, Ung Ka, et al
Scandinavian journal of gastroenterology 2015;50(11):1419-27

Fluorescence labeled microbubbles for multimodal imaging
Barrefelt Å, Zhao Y, Larsson Mk, Egri G, Kuiper Rv, Hamm J, et al
Biochemical and biophysical research communications 2015;464(3):737-42

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma
Huang J, Löhr Jm, Nilsson M, Segersvärd R, Matsson H, Verbeke C, et al
Clinical chemistry 2015;61(11):1408-16

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis
Marschallinger J, Krampert M, Couillard-despres S, Heuchel R, Bogdahn U, Aigner L
Experimental gerontology 2014;57():149-54

Desmoplasia and chemoresistance in pancreatic cancer
Schober M, Jesenofsky R, Faissner R, Weidenauer C, Hagmann W, Michl P, et al
Cancers 2014;6(4):2137-54

Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound
Gerling M, Zhao Y, Nania S, Norberg Kj, Verbeke Cs, Englert B, et al
Theranostics 2014;4(6):604-13

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing
Longati P, Jia X, Eimer J, Wagman A, Witt Mr, Rehnmark S, et al
BMC cancer 2013;13():95-

Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension
Wei Lh, Huang Xr, Zhang Y, Li Yq, Chen Hy, Heuchel R, et al
PloS one 2013;8(7):e70195-

Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice
Liu Gx, Li Yq, Huang Xr, Wei L, Chen Hy, Shi Yj, et al
PloS one 2013;8(1):e53573-

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro
Wang J, Zhao J, Chu Es, Mok Mt, Go My, Man K, et al
The Journal of pathology 2013;230(4):441-52

Smad7 regulates terminal maturation of chondrocytes in the growth plate
Estrada Kd, Wang W, Retting Kn, Chien Ct, Elkhoury Ff, Heuchel R, et al
Developmental biology 2013;382(2):375-84

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β
Dahal Bk, Heuchel R, Pullamsetti Ss, Wilhelm J, Ghofrani Ha, Weissmann N, et al
Pulmonary circulation 2011;1(2):259-68

Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene
Pazirandeh A, Sultana T, Mirza M, Rozell B, Hultenby K, Wallis K, et al
PLOS ONE 2011;6(6):e20203-

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy
Lonardo E, Hermann Pc, Mueller Mt, Huber S, Balic A, Miranda-lorenzo I, et al
CELL STEM CELL 2011;9(5):433-46

The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential
Chen Hy, Huang Xr, Wang Ws, Li Jh, Heuchel Rl, Chung Ack, et al
DIABETES 2011;60(2):590-601

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
Shimokawa N, Haglund K, Holter Sm, Grabbe C, Kirkin V, Koibuchi N, et al
EMBO JOURNAL 2010;29(14):2421-32

Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor beta- and Bone Morphogenetic Protein-Independent Manner
Krampert M, Chirasani Sr, Wachs Fp, Aigner R, Bogdahn U, Yingling Jm, et al

The human alpha 11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta 1 in a Smad- and Sp1-dependent manner
Lu N, Carracedo S, Ranta J, Heuchel R, Soininen R, Gullberg D
MATRIX BIOLOGY 2010;29(3):166-76

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
Chung Ack, Huang Xr, Zhou L, Heuchel R, Lai Kn, Lan Hy

Therapy with Cell Encapsulation for Substitution of Organ Function and Tumor Treatment
Lohr Jm, Heuchel R, Jesnowski R, Wallrapp C

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin
Krampert M, Heldin Ch, Heuchel Rl

Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice
Hamzavi J, Ehnert S, Godoy P, Ciuclan L, Weng H, Mertens Pr, et al

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta
Looman C, Sun T, Yu Y, Zieba A, Ahgren A, Feinstein R, et al

Expression and function of the gene encoding the voltage-dependent calcium channel beta 3-subunit in the mouse placenta
Singh U, Sun T, Looman C, Heuchel R, Elliott R, Freichel A, et al
PLACENTA 2007;28(5-6):412-20

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma
Suzuki S, Heldin Ch, Heuchel Rl
BMC CANCER 2007;:224-

Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro
Magnusson Pu, Looman C, Ahgren A, Wu Y, Claesson-welsh L, Heuchel Rl

Profibrogenic transforming growth Factor-beta/Activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
Weng Hl, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, et al
HEPATOLOGY 2007;46(4):1257-70

Deletion of exon I of SMAD7 in mice results in altered B cell responses
Li Rg, Rosendahl A, Brodin G, Cheng Am, Ahgren A, Sundquist C, et al
JOURNAL OF IMMUNOLOGY 2006;176(11):6777-84

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
Rolny C, Nilsson I, Magnusson P, Armulik A, Jakobsson L, Wentzel P, et al
BLOOD 2006;108(6):1877-86

Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate alpha 11 integrin chain expression in mesenchymal cells
Lu N, Heuchel R, Barczyk M, Zhang Wm, Gullberg D
MATRIX BIOLOGY 2006;25(2):118-29

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
Chiara F, Goumans Mj, Forsberg H, Ahgren A, Rasola A, Aspenstrom P, et al

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
Furuhashi M, Sjoblom T, Abramsson A, Ellingsen J, Micke P, Li H, et al
CANCER RESEARCH 2004;64(8):2725-33

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains
Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, et al
GENES & DEVELOPMENT 2003;17(5):586-90

Transforming growth factor-beta 1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
Edlund S, Bu Sh, Schuster N, Aspenstrom P, Heuchel R, Heldin Ne, et al

Transient activation of NF-kappa B through a TAK1/IKK kinase pathway by TGF-beta 1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
Arsura M, Panta Gr, Bilyeu Jd, Cavin Lg, Sovak Ma, Oliver Aa, et al
ONCOGENE 2003;22(3):412-25

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
Brodin G, Ahgren A, Ten Dijke P, Heldin Ch, Heuchel R

Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3 '-kinase and phospholipase C gamma signaling pathways
Tallquist Md, Klinghoffer Ra, Heuchel R, Mueting-nelsen Pf, Corrin Pd, Heldin Ch, et al
GENES & DEVELOPMENT 2000;14(24):3179-90

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3 ' kinase signaling
Heuchel R, Berg A, Tallquist M, Ahlen K, Reed Rk, Rubin K, et al

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
Gunes C, Heuchel R, Georgiev O, Muller Kh, Lichtlen P, Bluthmann H, et al
EMBO JOURNAL 1998;17(10):2846-54

Identification of Smad7, a TGF beta-inducible antagonist of TGF-beta signalling
Nakao A, Afrakhte M, Moren A, Nakayama T, Christian Jl, Heuchel R, et al
NATURE 1997;389(6651):631-5

Wan M, Heuchel R, Radtke F, Hunziker Pe, Kagi Jhr
EXPERIENTIA 1995;51(6):606-11

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