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Olga Loseva

Senior researcher

Visiting address : Kisp (Karolinska Institutet Science Park), Scilifelab, Alpha Building Level 4, Tomtebodavägen 23a 171 65 Solna, Sweden
Postal address : Department of Medical Biochemistry and Biophysics (MBB), C2, Thomas Helledays group, Po Box 1031 171 21 Solna, Sweden
Delivery address : Kisp (Karolinska Institutet Science Park), Scilifelab, Alpha Building Level 4, Tomtebodavägen 23a 171 65 Solna, Sweden

Publications

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-minguez S, Höglund A, Jacques Sa, Johansson L, Calderón-montaño Jm, Claesson M, et al
Journal of medicinal chemistry 2016;59(3):1140-8

Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements
Reddy Pt, Jaruga P, Nelson Bc, Lowenthal Ms, Jemth As, Loseva O, et al
Methods in enzymology 2016;566():305-32

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Coskun E, Jaruga P, Jemth As, Loseva O, Scanlan Ld, Tona A, et al
DNA repair 2015;33():101-10

PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription
Zhao H, Sifakis Eg, Sumida N, Millán-ariño L, Scholz Ba, Svensson Jp, et al
Molecular cell 2015;59(6):984-97

Processing of protein ADP-ribosylation by Nudix hydrolases
Palazzo L, Thomas B, Jemth As, Colby T, Leidecker O, Feijs Kl, et al
The Biochemical journal 2015;468(2):293-301

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H, Koolmeister T, Jemth As, Eshtad S, Jacques Sa, Ström Ce, et al
Nature 2014;508(7495):215-21

Castration therapy results in decreased Ku70 levels in prostate cancer
Al-ubaidi Fl, Schultz N, Loseva O, Egevad L, Granfors T, Helleday T
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1547-56

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA (vol 52, pg 3108, 2009)
Loseva O, Jemth As, Bryant He, Schuler H, Lehtio L, Karlberg T, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(41):34494-34494

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
Svensson Lm, Jemth As, Desroses M, Loseva O, Helleday T, Högbom M, et al
FEBS letters 2011;585(16):2617-21

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
Loseva O, Jemth As, Bryant He, Schüler H, Lehtiö L, Karlberg T, et al
The Journal of biological chemistry 2010;285(11):8054-60

Pathogen Entrapment by Transglutaminase-A Conserved Early Innate Immune Mechanism
Wang Z, Wilhelmsson C, Hyrsl P, Loof Tg, Dobes P, Klupp M, et al
PLOS PATHOGENS 2010;6(2):e1000763-

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant He, Petermann E, Schultz N, Jemth As, Loseva O, Issaeva N, et al
EMBO JOURNAL 2009;28(17):2601-15

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3
Lehtiö L, Jemth As, Collins R, Loseva O, Johansson A, Markova N, et al
Journal of medicinal chemistry 2009;52(9):3108-11

Evidence for an immune function of lepidopteran silk proteins
Korayem Am, Hauling T, Lesch C, Fabbri M, Lindgren M, Loseva O, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;352(2):317-22

Identification of proteins relocated to the chromatin following DNA damage
Loseva O, Johansson A, Helleday T
FEBS JOURNAL 2007;:79-79

Preliminary characterization of hemolymph coagulation in Anopheles gambiae larvae
Agianian B, Lesch C, Loseva O, Dushay Ms
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2007;31(9):879-88

Investigation of tyrosine phosphorylation triggered by LPS stimulation in Drosophila immune cells
Loseva O, Tollback P, Engstrom Y
MOLECULAR & CELLULAR PROTEOMICS 2005;4(8):S280-S280

Analysis of signal-dependent changes in the proteome of Drosophila blood cells during an immune response
Loseva O, Engstrom Y
MOLECULAR & CELLULAR PROTEOMICS 2004;3(8):796-808

Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method
Scherfer C, Karlsson C, Loseva O, Bidla G, Goto A, Havemann J, et al
CURRENT BIOLOGY 2004;14(7):625-9

Proteomic analysis of the Drosophila larval hemolymph clot
Karlsson C, Korayem Am, Scherfer C, Loseva O, Dushay Ms, Theopold U
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(50):52033-41

Proteomics of the Drosophila immune response
Engstrom Y, Loseva O, Theopold U
TRENDS IN BIOTECHNOLOGY 2004;22(11):600-5

Insect resistance to Bacillus thuringiensis - Alterations in the indianmeal moth larval gut proteome
Candas M, Loseva O, Oppert B, Kosaraju P, Bulla La
MOLECULAR & CELLULAR PROTEOMICS 2003;2(1):19-28

Changes in protease activity and Cry3Aa toxin binding in the Colorado potato beetle: implications for insect resistance to Bacillus thuringiensis toxins
Loseva O, Ibrahim M, Candas M, Koller Cn, Bauer Ls, Bulla La
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 2002;32(5):567-77

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